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Protein Overview: LAP3

General Information:
Name(s) found: LAP3 / YNL239W [SGD]
Description(s) found:
Found 22 descriptions.
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  • Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 454 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed articleLink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed articleLink to PubMed article]
    Biological Process: response to antibiotic [IDALink to PubMed article]
    Molecular Function: nucleic acid binding [TASLink to PubMed article]
    transcription regulator activity [IDALink to PubMed article]
    cysteine-type peptidase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSSIDISKI NSWNKEFQSD LTHQLATTVL KNYNADDALL NKTRLQKQDN RVFNTVVSTD  60
   61 STPVTNQKSS GRCWLFAATN QLRLNVLSEL NLKEFELSQA YLFFYDKLEK ANYFLDQIVS 120
  121 SADQDIDSRL VQYLLAAPTE DGGQYSMFLN LVKKYGLIPK DLYGDLPYST TASRKWNSLL 180
  181 TTKLREFAET LRTALKERSA DDSIIVTLRE QMQREIFRLM SLFMDIPPVQ PNEQFTWEYV 240
  241 DKDKKIHTIK STPLEFASKY AKLDPSTPVS LINDPRHPYG KLIKIDRLGN VLGGDAVIYL 300
  301 NVDNETLSKL VVKRLQNNKA VFFGSHTPKF MDKKTGVMDI ELWNYPAIGY NLPQQKASRI 360
  361 RYHESLMTHA MLITGCHVDE TSKLPLRYRV ENSWGKDSGK DGLYVMTQKY FEEYCFQIVV 420
  421 DINELPKELA SKFTSGKEEP IVLPIWDPMG ALAK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CLG1 CUE1 GTR1 HAM1 HRT1 LAP3 TFP1 VMA10 VMA13 VMA2 VMA7 VMA8 XDJ1 YIG1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen LOS1 LAP3 2 Unpublished Fields Lab Data
    View Screen MDM30 LAP3 2 Unpublished Fields Lab Data
    View Screen TEM1 LAP3 2 Unpublished Fields Lab Data
    View Screen IMP4 LAP3 2 Unpublished Fields Lab Data
    View Screen SLY1 LAP3 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data LAP3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..60]
    [267..454]    		 PSI-BLAST 10154.0 Bleomycin hydrolase
    2 View Details [61..266] PSI-BLAST 10154.0 Bleomycin hydrolase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • peptidase activity
    		•  3.93868691250608 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  3.68556833453114 bayes_pls_golite062009
  • cysteine-type peptidase activity
    		•  3.05412701733177 bayes_pls_golite062009
  • hydrolase activity
    		•  2.29464693834116 bayes_pls_golite062009
  • endopeptidase activity
    		•  2.26699762664334 bayes_pls_golite062009
  • cysteine-type endopeptidase activity
    		•  1.95802900199539 bayes_pls_golite062009
  • binding
    		•  1.22661689127383 bayes_pls_golite062009
  • small conjugating protein-specific protease activity
    		•  1.07520173658976 bayes_pls_golite062009
  • catalytic activity
    		•  1.05972260874031 bayes_pls_golite062009
  • protein binding
    		•  0.621642139747982 bayes_pls_golite062009
  • ubiquitin-specific protease activity
    		•  0.495368836247989 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.313326619937245 bayes_pls_golite062009
  • calcium-dependent cysteine-type endopeptidase activity
    		•  0.196538841514154 bayes_pls_golite062009
  • DNA binding
    		•  0.053663265361386 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle