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View Structure Prediction Details

Protein: LAP3
Organism: Saccharomyces cerevisiae
Length: 454 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LAP3.

Description E-value Query
Range
Subject
Range
gi|60655031, gi|... - gi|60655031|gb|AAX32079.1| bleomycin hydrolase [synthetic construct], gi|208965884|dbj|BAG72956.1| b...
BLMH - bleomycin hydrolase
0.0 [2..454] [3..455]
gi|1526452 - gi|1526452|dbj|BAA13333.1| bleomycin hydrolase [Rattus sp.]
BLMH_RAT - Bleomycin hydrolase OS=Rattus norvegicus GN=Blmh PE=1 SV=1
0.0 [2..453] [3..454]
gi|3429 - gi|3429|emb|CAA48878.1| bleomycin hydrolase [Saccharomyces cerevisiae]
0.0 [1..454] [30..483]
BLMH_CHICK - Bleomycin hydrolase OS=Gallus gallus GN=BLMH PE=1 SV=1
0.0 [2..454] [3..455]
PEPC_STRTR - Aminopeptidase C OS=Streptococcus thermophilus GN=pepC PE=3 SV=1
0.0 [3..453] [2..443]

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Predicted Domain #1
Region A:
Residues: [1-60]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSSIDISKI NSWNKEFQSD LTHQLATTVL KNYNADDALL NKTRLQKQDN RVFNTVVSTD  60
   61 

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [267-454]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TPVSLINDPR HPYGKLIKID RLGNVLGGDA VIYLNVDNET LSKLVVKRLQ NNKAVFFGSH  60
   61 TPKFMDKKTG VMDIELWNYP AIGYNLPQQK ASRIRYHESL MTHAMLITGC HVDETSKLPL 120
  121 RYRVENSWGK DSGKDGLYVM TQKYFEEYCF QIVVDINELP KELASKFTSG KEEPIVLPIW 180
  181 DPMGALAK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10154.0
Match: 1gcb__
Description: Bleomycin hydrolase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 3.93868691250608 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 3.68556833453114 bayes_pls_golite062009
cysteine-type peptidase activity 3.05412701733177 bayes_pls_golite062009
hydrolase activity 2.29464693834116 bayes_pls_golite062009
endopeptidase activity 2.26699762664334 bayes_pls_golite062009
cysteine-type endopeptidase activity 1.95802900199539 bayes_pls_golite062009
binding 1.22661689127383 bayes_pls_golite062009
small conjugating protein-specific protease activity 1.07520173658976 bayes_pls_golite062009
catalytic activity 1.05972260874031 bayes_pls_golite062009
protein binding 0.621642139747982 bayes_pls_golite062009
ubiquitin-specific protease activity 0.495368836247989 bayes_pls_golite062009
nucleic acid binding 0.313326619937245 bayes_pls_golite062009
calcium-dependent cysteine-type endopeptidase activity 0.196538841514154 bayes_pls_golite062009
DNA binding 0.053663265361386 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [61-266]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STPVTNQKSS GRCWLFAATN QLRLNVLSEL NLKEFELSQA YLFFYDKLEK ANYFLDQIVS  60
   61 SADQDIDSRL VQYLLAAPTE DGGQYSMFLN LVKKYGLIPK DLYGDLPYST TASRKWNSLL 120
  121 TTKLREFAET LRTALKERSA DDSIIVTLRE QMQREIFRLM SLFMDIPPVQ PNEQFTWEYV 180
  181 DKDKKIHTIK STPLEFASKY AKLDPS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10154.0
Match: 1gcb__
Description: Bleomycin hydrolase
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle