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Protein Overview: RPN2

General Information:
Name(s) found: RPN2 / YIL075C [SGD]
Description(s) found:
Found 22 descriptions.
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  • Subunit of the 26S proteasome, substrate of the N-acetyltransferase Nat1p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 945 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    proteasome regulatory particle, base subcomplex [IPILink to PubMed article]
    Biological Process: ubiquitin-dependent protein catabolic process [IMPLink to PubMed article][IPILink to PubMed article]
    Molecular Function: endopeptidase activity [IMPLink to PubMed article]
    protein binding, bridging [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLTTAAPLL ALLRENQDSV KTYALESINN VVDQLWSEIS NELPDIEALY DDDTFSDREM  60
   61 AALIASKVYY NLGEYESAVK YALAAKDRFD IDEKSQFVET IVSKSIEMYV QEASKQYTKD 120
  121 EQFYTKDIID PKLTSIFERM IEKCLKASEL KLALGIALEG YRLDIIESAL KSKLDQDSTS 180
  181 ENVKIINYLL TLAITTVTNS KFRSSILRKS FDFLMNMPNC DYLTLNKVVV NLNDAGLALQ 240
  241 LFKKLKEEND EGLSAQIAFD LVSSASQQLL EILVTELTAQ GYDPALLNIL SGLPTCDYYN 300
  301 TFLLNNKNID IGLLNKSKSS LDGKFSLFHT AVSVANGFMH AGTTDNSFIK ANLPWLGKAQ 360
  361 NWAKFTATAS LGVIHKGNLL EGKKVMAPYL PGSRASSRFI KGGSLYGLGL IYAGFGRDTT 420
  421 DYLKNIIVEN SGTSGDEDVD VLLHGASLGI GLAAMGSANI EVYEALKEVL YNDSATSGEA 480
  481 AALGMGLCML GTGKPEAIHD MFTYSQETQH GNITRGLAVG LALINYGRQE LADDLITKML 540
  541 ASDESLLRYG GAFTIALAYA GTGNNSAVKR LLHVAVSDSN DDVRRAAVIA LGFVLLRDYT 600
  601 TVPRIVQLLS KSHNAHVRCG TAFALGIACA GKGLQSAIDV LDPLTKDPVD FVRQAAMIAL 660
  661 SMILIQQTEK LNPQVADINK NFLSVITNKH QEGLAKFGAC VAQGIMNAGG RNVTIQLENA 720
  721 DTGTLDTKSV VGLVMFSQFW YWFPLAHFLS LSFTPTTVIG IRGSDQAIPK FQMNCYAKED 780
  781 AFSYPRMYEE ASGKEVEKVA TAVLSTTARA KARAKKTKKE KGPNEEEKKK EHEEKEKERE 840
  841 TNKKGIKETK ENDEEFYKNK YSSKPYKVDN MTRILPQQSR YISFIKDDRF VPVRKFKGNN 900
  901 GVVVLRDREP KEPVALIETV RQMKDVNAPL PTPFKVDDNV DFPSA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CDC39 CLU1 ECM29 EFT2, EFT1 GSG1 ILV1 NAS6 OSH7 POL4 RPN1 RPN10 RPN11 RPN12 RPN13 RPN2 RPN3 RPN5 RPN6 RPN7 RPN8 RPN9 RPT1 RPT2 RPT3 RPT4 RPT5 RPT6 SAM1 SEC18 SEM1 SLX5 SPG5 SWA2 TOD6 UBP6 URA3
    View Details (MIPS) Mewes HW, et al. (2004) NAS6 RPN1 RPN10 RPN11 RPN12 RPN2 RPN3 RPN5 RPN6 RPN7 RPN8 RPN9 RPT1 RPT2 RPT3 RPT4 RPT5 RPT6
    View Details Krogan NJ, et al. (2006) CSI1 CSN9 ERV46 FPR2 HUL5 IQG1 MOT1 MPT5 NAS6 NMD3 NPT1 PCI8 PEP1 PST1 PUS9 RPN1 RPN10 RPN11 RPN12 RPN13 RPN14 RPN2 RPN5 RPN6 RPN7 RPN8 RPN9 RPT1 RPT2 RPT3 RPT4 RPT5 RPT6 RRI1 RRI2 SEC18 SEM1 SKP1 SPG5 SPO77 SQT1 SWA2 TCB2 TIP41 TOD6 TOR2 TSR4 UBP6 YEN1 YKL027W YMR258C YNL022C YPR003C YPT52
    View Details Gavin AC, et al. (2006) IMP4 RPN2 YOL098C
    View Details Qiu et al. (2008) CIC1 NAS6 PRE1 PRE10 PRE4 PRE5 PRE6 PRE7 PRE8 PUP3 RPN1 RPN10 RPN11 RPN12 RPN13 RPN2 RPN3 RPN5 RPN6 RPN7 RPN8 RPN9 RPT1 RPT2 RPT3 RPT4 RPT5 RPT6 SCL1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data RPN2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..148] ab initio 8.22 No description for 1b3uA was found.
    2 View Details [149..235] ab initio 8.22 No description for 1b3uA was found.
    3 View Details [236..360] ab initio 8.22 No description for 1b3uA was found.
    4 View Details [361..560] PSI-BLAST 53.221849 Constant regulatory domain of protein phosphatase 2a, pr65alpha
    5 View Details [561..721] PSI-BLAST 53.221849 Constant regulatory domain of protein phosphatase 2a, pr65alpha
    6 View Details [722..801] PSI-BLAST 3.0 V-region of surface antigen I/II (SA I/II, PAC)
    7 View Details [802..945] MSA 21.348997 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.40

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle