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Protein Overview: KRE2

General Information:
Name(s) found: KRE2 / YDR483W [SGD]
Description(s) found:
Found 30 descriptions.
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  • Alpha1,2-mannosyltransferase of the Golgi involved in protein mannosylation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 442 amino acids

    Gene Ontology:
    Cellular Component: Golgi apparatus [ISSLink to PubMed article]
    Biological Process: cell wall mannoprotein biosynthetic process [IMPLink to PubMed article]
    protein amino acid O-linked glycosylation [IMPLink to PubMed article]
    N-glycan processing [IMPLink to PubMed article]
    Molecular Function: alpha-1,2-mannosyltransferase activity [IDALink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALFLSKRLL RFTVIAGAVI VLLLTLNSNS RTQQYIPSSI SAAFDFTSGS ISPEQQVISE  60
   61 ENDAKKLEQS ALNSEASEDS EAMDEESKAL KAAAEKADAP IDTKTTMDYI TPSFANKAGK 120
  121 PKACYVTLVR NKELKGLLSS IKYVENKINK KFPYPWVFLN DEPFTEEFKE AVTKAVSSEV 180
  181 KFGILPKEHW SYPEWINQTK AAEIRADAAT KYIYGGSESY RHMCRYQSGF FWRHELLEEY 240
  241 DWYWRVEPDI KLYCDINYDV FKWMQENEKV YGFTVSIHEY EVTIPTLWQT SMDFIKKNPE 300
  301 YLDENNLMSF LSNDNGKTYN LCHFWSNFEI ANLNLWRSPA YREYFDTLDH QGGFFYERWG 360
  361 DAPVHSIAAA LFLPKDKIHY FSDIGYHHPP YDNCPLDKEV YNSNNCECDQ GNDFTFQGYS 420
  421 CGKEYYDAQG LVKPKNWKKF RE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Gavin AC, et al. (2006) DOS2 KRE2
    View Details Qiu et al. (2008) KRE2 KTR1 KTR4 MNN1 MNN5 OCH1 VAN1 YUR1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run NAF1 No Comments Hazbun TR, et al. (2003)
    View Run TOR2 No Comments Reinke A, et al. (2004)
    View Run MIA40 No Comments Hazbun TR, et al. (2003)
    View Run SEC10 No Comments De Craene, J., et al. (2006)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX14 - mixture in detergent (control). Hao Xu, et al. (2010)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data KRE2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..442] Pfam 241.721246 Glycolipid 2-alpha-mannosyltransferase No confident structure predictions are available.
    2 View Details [93..442] PSI-BLAST 169.0 Crystal structure of yeast alpha1,2-mannosyltransferase Kre2p/Mnt1p

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • alpha-1,2-mannosyltransferase activity
    		•  6.0576932895264 bayes_pls_golite062009
  • mannosyltransferase activity
    		•  5.57855076532185 bayes_pls_golite062009
  • transferase activity, transferring hexosyl groups
    		•  4.49413422196176 bayes_pls_golite062009
  • UDP-glycosyltransferase activity
    		•  4.08451171179562 bayes_pls_golite062009
  • acetylgalactosaminyltransferase activity
    		•  3.4614674054855 bayes_pls_golite062009
  • transferase activity
    		•  3.32517438937547 bayes_pls_golite062009
  • polypeptide N-acetylgalactosaminyltransferase activity
    		•  3.19923094610567 bayes_pls_golite062009
  • transferase activity, transferring glycosyl groups
    		•  2.60650378115696 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  2.51696952719873 bayes_pls_golite062009
  • catalytic activity
    		•  1.88676710996045 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  1.36890882280676 bayes_pls_golite062009
  • uridylyltransferase activity
    		•  1.27888067902271 bayes_pls_golite062009
  • binding
    		•  0.948692623641759 bayes_pls_golite062009
  • glucuronosyltransferase activity
    		•  0.36353543999278 bayes_pls_golite062009
  • protein binding
    		•  0.124656890356575 bayes_pls_golite062009
  • UDP-galactosyltransferase activity
    		•  0.10185872015123 bayes_pls_golite062009
  • galactosyltransferase activity
    		•  0.0931461042017721 bayes_pls_golite062009
  • acetylglucosaminyltransferase activity
    		•  0.0562130308868509 bayes_pls_golite062009
  • alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity
    		•  0.0339369954475406 bayes_pls_golite062009
  • intramolecular oxidoreductase activity
    		•  0.0122078907283503 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
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