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View Structure Prediction Details

Protein: KRE2
Organism: Saccharomyces cerevisiae
Length: 442 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for KRE2.

Description E-value Query
Range
Subject
Range
gi|190404595 - gi|190404595|gb|EDV07862.1| alpha-1,2-mannosyltransferase [Saccharomyces cerevisiae RM11-1a]
gi|207346225 - gi|207346225|gb|EDZ72784.1| YDR483Wp-like protein [Saccharomyces cerevisiae AWRI1631]
KRE2_YEAST - Glycolipid 2-alpha-mannosyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=K...
KRE2 - Alpha1,2-mannosyltransferase of the Golgi involved in protein mannosylation
0.0 [1..442] [1..442]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [54..441] [73..461]
MNT2_CANAX, MNT2... - Probable mannosyltransferase MNT2 OS=Candida albicans GN=MNT2 PE=3 SV=2, Probable mannosyltransferas...
0.0 [54..441] [73..461]
SPBC19C7.12c - alpha-1,2-mannosyltransferase
OMH1_SCHPO - O-glycoside alpha-1,2-mannosyltransferase omh1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843...
0.0 [101..440] [42..388]

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Predicted Domain #1
Region A:
Residues: [1-442]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALFLSKRLL RFTVIAGAVI VLLLTLNSNS RTQQYIPSSI SAAFDFTSGS ISPEQQVISE  60
   61 ENDAKKLEQS ALNSEASEDS EAMDEESKAL KAAAEKADAP IDTKTTMDYI TPSFANKAGK 120
  121 PKACYVTLVR NKELKGLLSS IKYVENKINK KFPYPWVFLN DEPFTEEFKE AVTKAVSSEV 180
  181 KFGILPKEHW SYPEWINQTK AAEIRADAAT KYIYGGSESY RHMCRYQSGF FWRHELLEEY 240
  241 DWYWRVEPDI KLYCDINYDV FKWMQENEKV YGFTVSIHEY EVTIPTLWQT SMDFIKKNPE 300
  301 YLDENNLMSF LSNDNGKTYN LCHFWSNFEI ANLNLWRSPA YREYFDTLDH QGGFFYERWG 360
  361 DAPVHSIAAA LFLPKDKIHY FSDIGYHHPP YDNCPLDKEV YNSNNCECDQ GNDFTFQGYS 420
  421 CGKEYYDAQG LVKPKNWKKF RE

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 241.721246
Match: PF01793
Description: Glycolipid 2-alpha-mannosyltransferase

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [93-442]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AAEKADAPID TKTTMDYITP SFANKAGKPK ACYVTLVRNK ELKGLLSSIK YVENKINKKF  60
   61 PYPWVFLNDE PFTEEFKEAV TKAVSSEVKF GILPKEHWSY PEWINQTKAA EIRADAATKY 120
  121 IYGGSESYRH MCRYQSGFFW RHELLEEYDW YWRVEPDIKL YCDINYDVFK WMQENEKVYG 180
  181 FTVSIHEYEV TIPTLWQTSM DFIKKNPEYL DENNLMSFLS NDNGKTYNLC HFWSNFEIAN 240
  241 LNLWRSPAYR EYFDTLDHQG GFFYERWGDA PVHSIAAALF LPKDKIHYFS DIGYHHPPYD 300
  301 NCPLDKEVYN SNNCECDQGN DFTFQGYSCG KEYYDAQGLV KPKNWKKFRE 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 169.0
Match: 1s4nA
Description: Crystal structure of yeast alpha1,2-mannosyltransferase Kre2p/Mnt1p
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
alpha-1,2-mannosyltransferase activity 6.0576932895264 bayes_pls_golite062009
mannosyltransferase activity 5.57855076532185 bayes_pls_golite062009
transferase activity, transferring hexosyl groups 4.49413422196176 bayes_pls_golite062009
UDP-glycosyltransferase activity 4.08451171179562 bayes_pls_golite062009
acetylgalactosaminyltransferase activity 3.4614674054855 bayes_pls_golite062009
transferase activity 3.32517438937547 bayes_pls_golite062009
polypeptide N-acetylgalactosaminyltransferase activity 3.19923094610567 bayes_pls_golite062009
transferase activity, transferring glycosyl groups 2.60650378115696 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 2.51696952719873 bayes_pls_golite062009
catalytic activity 1.88676710996045 bayes_pls_golite062009
nucleotidyltransferase activity 1.36890882280676 bayes_pls_golite062009
uridylyltransferase activity 1.27888067902271 bayes_pls_golite062009
binding 0.948692623641759 bayes_pls_golite062009
glucuronosyltransferase activity 0.36353543999278 bayes_pls_golite062009
protein binding 0.124656890356575 bayes_pls_golite062009
UDP-galactosyltransferase activity 0.10185872015123 bayes_pls_golite062009
galactosyltransferase activity 0.0931461042017721 bayes_pls_golite062009
acetylglucosaminyltransferase activity 0.0562130308868509 bayes_pls_golite062009
alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity 0.0339369954475406 bayes_pls_golite062009
intramolecular oxidoreductase activity 0.0122078907283503 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle