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Protein Overview: THI3

General Information:
Name(s) found: THI3 / YDL080C [SGD]
Description(s) found:
Found 26 descriptions.
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  • Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols; required for expression of enzymes involved in thiamine biosynthesis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 609 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed articleLink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: positive regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed article]
    thiamin biosynthetic process [IMPLink to PubMed article][IPILink to PubMed article][TASLink to PubMed article]
    Molecular Function: transcription activator activity [IMPLink to PubMed article]
    carboxy-lyase activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSSYTQRYA LPKCIAISDY LFHRLNQLNI HTIFGLSGEF SMPLLDKLYN IPNLRWAGNS  60
   61 NELNAAYAAD GYSRLKGLGC LITTFGVGEL SAINGVAGSY AEHVGILHIV GMPPTSAQTK 120
  121 QLLLHHTLGN GDFTVFHRIA SDVACYTTLI IDSELCADEV DKCIKKAWIE QRPVYMGMPV 180
  181 NQVNLPIESA RLNTPLDLQL HKNDPDVEKE VISRILSFIY KSQNPAIIVD ACTSRQNLIE 240
  241 ETKELCNRLK FPVFVTPMGK GTVNETDPQF GGVFTGSISA PEVREVVDFA DFIIVIGCML 300
  301 SEFSTSTFHF QYKTKNCALL YSTSVKLKNA TYPDLSIKLL LQKILANLDE SKLSYQPSEQ 360
  361 PSMMVPRPYP AGNVLLRQEW VWNEISHWFQ PGDIIITETG ASAFGVNQTR FPVNTLGISQ 420
  421 ALWGSVGYTM GACLGAEFAV QEINKDKFPA TKHRVILFMG DGAFQLTVQE LSTIVKWGLT 480
  481 PYIFVMNNQG YSVDRFLHHR SDASYYDIQP WNYLGLLRVF GCTNYETKKI ITVGEFRSMI 540
  541 SDPNFATNDK IRMIEIMLPP RDVPQALLDR WVVEKEQSKQ VQEENENSSA VNTPTPEFQP 600
  601 LLKKNQVGY

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Gavin AC, et al. (2002) CCT2 FYV8 THI3
    View Details Ho Y, et al. (2002) BFR2 BIR1 BNA5 CDC7 ECM10 JIP3 NUT1 PDC5 PDC6 PST2 RPC19 SAR1 SEC27 STI1 THI3 TPS1 UBI4 VAC14

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #16 Mitotic-New search criteria Keck JM, et al. (2011)
    View Run None Entered #18 Mitotic Prep4-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data THI3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..199] PSI-BLAST 1921.0 Pyruvate decarboxylase
    2 View Details [200..364] PSI-BLAST 1921.0 Pyruvate decarboxylase
    3 View Details [365..609] PSI-BLAST 1921.0 Pyruvate decarboxylase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • acetolactate synthase activity
    		•  12.903449876837 bayes_pls_golite062009
  • transferase activity, transferring aldehyde or ketonic groups
    		•  12.3239025230705 bayes_pls_golite062009
  • pyruvate dehydrogenase activity
    		•  5.28857071459273 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
    		•  5.21233670052586 bayes_pls_golite062009
  • pyruvate dehydrogenase (acetyl-transferring) activity
    		•  5.08663245333808 bayes_pls_golite062009
  • NAD or NADH binding
    		•  3.93430700665136 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.9155913558118 bayes_pls_golite062009
  • DNA binding
    		•  2.43141001866996 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.41433477472968 bayes_pls_golite062009
  • catalytic activity
    		•  2.25537597692103 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  2.15444163802756 bayes_pls_golite062009
  • transketolase activity
    		•  2.13705987575498 bayes_pls_golite062009
  • NAD-dependent protein deacetylase activity
    		•  2.09493047697397 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity
    		•  2.09493047697397 bayes_pls_golite062009
  • histone deacetylase activity
    		•  2.07818242335598 bayes_pls_golite062009
  • protein deacetylase activity
    		•  2.07076853700185 bayes_pls_golite062009
  • deoxyhypusine synthase activity
    		•  2.04735838056767 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  1.98546381612935 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  1.82969293063325 bayes_pls_golite062009
  • hydrolase activity
    		•  1.43067365161346 bayes_pls_golite062009
  • transcription factor activity
    		•  1.30143289828088 bayes_pls_golite062009
  • deacetylase activity
    		•  1.21596867135219 bayes_pls_golite062009
  • binding
    		•  1.17940168894417 bayes_pls_golite062009
  • transcription factor binding
    		•  1.14766678956419 bayes_pls_golite062009
  • phenylpyruvate decarboxylase activity
    		•  1.11553401986553 bayes_pls_golite062009
  • 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity
    		•  1.07090849835369 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  1.0611726850452 bayes_pls_golite062009
  • protein binding
    		•  0.992849906276347 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.78591260444574 bayes_pls_golite062009
  • alpha-ketoacid dehydrogenase activity
    		•  0.750929351082237 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.614654207326026 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.54005617175343 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.51426028502998 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  0.492590326775569 bayes_pls_golite062009
  • transferase activity
    		•  0.413024577830522 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.40721151987565 bayes_pls_golite062009
  • pyruvate decarboxylase activity
    		•  0.198062360371269 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  0.114062221123972 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.89

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle