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Protein Overview: crk1

General Information:
Name(s) found: crk1 / SPBC19F8.07 [Sanger Pombe]
Description(s) found:
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  • gi|987976|emb|CAA62621.1| Cdk-activating kinase [Schizosaccharomyces pombe] [NCBI NR]
  • gi|3150140|emb|CAA19127.1| cyclin-dependent protein kinase/CDK-activating kinase Mcs6 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|26392384|sp|Q12126.1|CRK1_SCHPO RecName: Full=Serine/threonine-protein kinase crk1; AltName: Full=Mitotic catastrophe suppressor 6 [NCBI NR]
  • pir||S66145 Cdk-activating protein kinase (EC 2.7.1.-) chain mop1 - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|19113141|ref|NP_596349.1| cyclin-dependent kinase activating kinase Crk1 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|1063602|gb|AAB00356.1| mammalian CAK homologue [NCBI NR]
  • cyclin-dependent kinase activating kinase Crk1 [Sanger Pombe]
  • Serine/threonine-protein kinase crk1 OS=Schizosaccharomyces pombe GN=crk1 PE=1 SV=1 [Swiss-Prot]
  • CDK-ACTIVATING KINASE; PUTATIVE TRANSCRIPTION INITIATION FACTOR TFIIH SUBUNIT; CYCLIN-DEPENDENT KINASE ACTIVATING KINASE (CAK); SIMILAR TO S. CEREVISIAE KIN28: Q12126; [pompepVF.fasta]
  • CDK-ACTIVATING KINASE; PUTATIVE TRANSCRIPTION INITIATION FACTOR TFIIH SUBUNIT; CYCLIN-DEPENDENT KINASE ACTIVATING KINASE (CAK): Q12126; [pompepV13]
  • Serine/threonine-protein kinase crk1 (EC 2.7.1.37) [pompep4896]
  • |crk1|mop1, mcs6|serine/threonine protein kinase [pompepnew.fasta]
  • |crk1|mop1, mcs6|serine/threonine protein kinase|Schizosaccharomyces pombe|chr 2|||Manual [pombe041504.fasta]
  • |crk1|mop1, mcs6|cyclin-dependent kinase activating kinase |Schizosaccharomyces pombe|chr 2|||Manual [pompep2242005.fasta]
  • cdk-activating kinase [Schizosaccharomyces pombe]gi|987976|emb|CAA62621.1| Cdk-activating kinase [Schizosaccharomyces pombe]gi|3150140|emb|CAA19127.1| crk1 [Schizosaccharomyces pombe]gi|26392384|sp|Q12126|CRK1_SCHPO Serine/threonine-protein kinase crk1 [nrdb_11152004_Chlamydomonas]
  • (Q12126) Serine/threonine-protein kinase crk1 (EC 2.7.1.37) [pompep4896_normal_reversed]
  • |mcs6|crk1, mop1, cdk7|cyclin-dependent protein kinase/CDK-activating kinase Mcs6|Schizosaccharomyces pombe|chr 2|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • Serine/threonine-protein kinase crk1 (Mitotic catastrophe suppressor 6) [nr-271106-contam.fasta]
  • Cdk-activating kinase [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • mammalian CAK homologue [nr-271106-contam.fasta]
  • SPBC19F8.07 [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • hypothetical protein SPBC19F8.07 [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • |crk1|mop1, mcs6|cyclin-dependent kinase activating kinase Crk1|Schizosaccharomyces pombe|chr 2|||Manual [spombe-190209-contam.fasta]
  • Serine/threonine-protein kinase crk1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=crk1 PE=1 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 335 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    holo TFIIH complex [ISSLink to PubMed article]
    Biological Process: phosphorylation of RNA polymerase II C-terminal domain [IMPLink to PubMed article]
    positive regulation of phosphorylation [ICLink to PubMed article]
    P-TEFb-cap methyltransferase complex localization [IMPLink to PubMed article]
    regulation of gene-specific transcription elongation from RNA polymerase II promoter [IMPLink to PubMed article]
    regulation of catalytic activity [ICLink to PubMed article]
    regulation of cell cycle [IGILink to PubMed article]
    positive regulation of transcription from RNA polymerase II promoter [ISSLink to PubMed article]
    protein amino acid phosphorylation [ICLink to PubMed article]
    Molecular Function: cyclin-dependent protein kinase activating kinase activity [IGILink to PubMed article]
    ATP binding [IEA]
    RNA polymerase II carboxy-terminal domain kinase activity [IDALink to PubMed article]
    general RNA polymerase II transcription factor activity [ISSLink to PubMed article]
    cyclin-dependent protein kinase activity [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDIEKSDKWT YVKERKVGEG TYAVVFLGRQ KETNRRVAIK KIKVGQFKDG IDISALREIK  60
   61 FLRESRHDNV IELVDVFSTK SNLNIILEFL DSDLEMLIKD KFIVFQPAHI KSWMVMLLRG 120
  121 LHHIHSRFIL HRDLKPNNLL ISSDGVLKLA DFGLSRDFGT PSHMSHQVIT RWYRPPELFM 180
  181 GCRSYGTGVD MWSVGCIFAE LMLRTPYLPG ESDLDQLNVI FRALGTPEPE VIKSMQQLPN 240
  241 YVEMKHIPPP NGGMEALFSA AGHEEIDLLK MMLDYNPYRR PTAQQALEHH YFSALPKPTH 300
  301 PSLLPRKGGE EGIKHVSSDL QRQNNFPMRA NIKFV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..335] PSI-BLAST 82.045757 Crystal Structure of Human CDK7

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • acetylcholine receptor activator activity
    		•  5.9159846946654 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  5.68265749805481 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  4.62392503670521 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • structural molecule activity
    		•  3.82327979736517 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  3.41480681854114 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  3.40140621607334 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  2.8153155526437 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  2.79505438761262 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.59526003830791 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.52531786618214 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.46424348876434 bayes_pls_golite062009
  • signal transducer activity
    		•  2.40586892801446 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.40586892801446 bayes_pls_golite062009
  • receptor activity
    		•  2.39311927684508 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.37122853419919 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  2.30873410607588 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  2.30873410607588 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • tubulin binding
    		•  2.18641675163967 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.12615078788254 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  2.10379226653669 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  1.94085498993561 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  1.9016235206634 bayes_pls_golite062009
  • microtubule binding
    		•  1.88110801192607 bayes_pls_golite062009
  • actin binding
    		•  1.87817875565699 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.81249386965144 bayes_pls_golite062009
  • telethonin binding
    		•  1.75733591474207 bayes_pls_golite062009
  • transforming growth factor beta receptor activity, type I
    		•  1.74645334586495 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  1.74206248731815 bayes_pls_golite062009
  • activin binding
    		•  1.69795678545106 bayes_pls_golite062009
  • fibroblast growth factor 1 binding
    		•  1.66976264488423 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • activin receptor activity
    		•  1.64506335968643 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  1.62657794525303 bayes_pls_golite062009
  • JUN kinase kinase kinase activity
    		•  1.60259443694567 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.56748951434625 bayes_pls_golite062009
  • growth factor binding
    		•  1.53863828216563 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.46547714006072 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  1.42275431028856 bayes_pls_golite062009
  • DNA binding
    		•  1.35333135345112 bayes_pls_golite062009
  • ErbB-3 class receptor binding
    		•  1.34841233233438 bayes_pls_golite062009
  • ErbB-2 class receptor binding
    		•  1.33825339298024 bayes_pls_golite062009
  • kinase binding
    		•  1.26086833316556 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  1.2266791546014 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • transcription elongation regulator activity
    		•  1.16995153203536 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.14496167267281 bayes_pls_golite062009
  • transporter activity
    		•  1.11833481501707 bayes_pls_golite062009
  • non-membrane spanning protein tyrosine kinase activity
    		•  1.11664317075762 bayes_pls_golite062009
  • transcription factor activity
    		•  1.10928254946881 bayes_pls_golite062009
  • protein kinase binding
    		•  1.06030596516506 bayes_pls_golite062009
  • cation channel activity
    		•  1.04999722123563 bayes_pls_golite062009
  • SMAD binding
    		•  1.02108562119195 bayes_pls_golite062009
  • transcription activator activity
    		•  0.997272622653026 bayes_pls_golite062009
  • PTB domain binding
    		•  0.9900774724568 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.97575992765505 bayes_pls_golite062009
  • alpha-actinin binding
    		•  0.877087652539674 bayes_pls_golite062009
  • insulin-like growth factor receptor binding
    		•  0.872782211382796 bayes_pls_golite062009
  • fibroblast growth factor binding
    		•  0.870666814073948 bayes_pls_golite062009
  • activin receptor activity, type I
    		•  0.82317428935631 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • actin filament binding
    		•  0.794152600084 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  0.75189004129952 bayes_pls_golite062009
  • receptor serine/threonine kinase binding
    		•  0.728917900114111 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.705905455086486 bayes_pls_golite062009
  • transforming growth factor beta receptor binding
    		•  0.705634826374884 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase binding
    		•  0.705634826374884 bayes_pls_golite062009
  • hormone receptor binding
    		•  0.705067960165986 bayes_pls_golite062009
  • beta-catenin binding
    		•  0.693246095477001 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.612883428421652 bayes_pls_golite062009
  • cyclin-dependent protein kinase activating kinase activity
    		•  0.529121666062889 bayes_pls_golite062009
  • steroid hormone receptor binding
    		•  0.505233004492768 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • enzyme binding
    		•  0.46284745266176 bayes_pls_golite062009
  • transforming growth factor beta binding
    		•  0.435457844706269 bayes_pls_golite062009
  • protein kinase C activity
    		•  0.41587987561486 bayes_pls_golite062009
  • cyclin-dependent protein kinase regulator activity
    		•  0.406297251827056 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.401250804041384 bayes_pls_golite062009
  • structural constituent of muscle
    		•  0.399773397398032 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.318153468064373 bayes_pls_golite062009
  • channel activity
    		•  0.287189255116606 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.287189255116606 bayes_pls_golite062009
  • insulin receptor binding
    		•  0.266450215230107 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.261869836686301 bayes_pls_golite062009
  • RNA binding
    		•  0.245748631571068 bayes_pls_golite062009
  • ion channel activity
    		•  0.241519346930618 bayes_pls_golite062009
  • nuclear hormone receptor binding
    		•  0.240883589532225 bayes_pls_golite062009
  • protein complex binding
    		•  0.239339759110451 bayes_pls_golite062009
  • insulin receptor activity
    		•  0.237134032032089 bayes_pls_golite062009
  • SH2 domain binding
    		•  0.226760162354251 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  0.149958560815481 bayes_pls_golite062009
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  0.149958560815481 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  0.14842991990838 bayes_pls_golite062009
  • peptide binding
    		•  0.118578378753757 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0040394359628233 bayes_pls_golite062009
  • brain-derived neurotrophic factor binding
    		•  0.00315481858218991 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle