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Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton). Interacting selectively and non-covalently with muscle isoforms of actinin. Muscle alpha-actinin isoforms are found in skeletal and cardiac muscle and are localized to the Z-disc. Interacting selectively and non-covalently with alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats. Interacting selectively and non-covalently with actinin, any member of a family of proteins that crosslink F-actin. Interacting selectively and non-covalently with nonmuscle isoforms of actinin. Nonmuscle alpha-actinin is found at the leading edge of motile cells, cell adhesion sites, focal contacts and along actin stress fibers in migrating cells.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: alpha-actinin binding
Acc: GO:0051393
Aspect: Molecular Function
Desc: Interacting selectively and non-covalently with alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats.
Proteins in PDR annotated with:
   This term: 20 [Search]
   Term or descendants: 26 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0051393 - alpha-actinin binding (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle