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Protein Overview: Traf6-PA

General Information:
Name(s) found: Traf6-PA / FBpp0071136 [FlyBase]
Description(s) found:
Found 23 descriptions.
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  • The gene TNF-receptor-associated factor 6 is referred to in FlyBase by the symbol Dmel\Traf6 (CG10961, FBgn0026318). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:8048623..8051399. It has the cytological map location 7D16. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: innate immune response; regulation of I-kappaB kinase/NF-kappaB cascade. 14 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 475 amino acids

    Gene Ontology:
    Cellular Component: intracellular [TAS]
    Biological Process: dorsal closure [TAS]
    Toll signaling pathway [TAS]
    signal transduction [NAS]
    innate immune response [IMP]
    regulation of I-kappaB kinase/NF-kappaB cascade [IMP]
    defense response [NAS]
    Molecular Function: zinc ion binding [IEA]
    protein binding [IPI]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQRVQADQKP ARMHQHAHTH SHAHSLQHAE EKEHNSNEMT TNLSSTGRIA ASSSATPSAA  60
   61 AGGGASGAPT PPKSLALNQN HHYAPGSDTS GEQEEELLDS RYECAICIDW LNEPVLTSCG 120
  121 HRFCRSCLTA WMQKNNQCCP MDNKRLSAEH DIFPDNYTRR EIEQLKRDCP NSSLGCSVVA 180
  181 SPIELHRHLP SCPYRRQQEP QEEKCPFAKI KCDFVGRPET NQLEEHLKAD MPHHMQLMLQ 240
  241 AFQQTAIATW QPHKPSTSGA AVENGHGQQQ LPPPPQYANG VDEQIVQTMY QRIVVLEQRT 300
  301 REQETRLENM QKQLRLARQQ APVDPRYSNG TIVWRIEQLG ALVARLRANA NNQVYSHECY 360
  361 TSPHGYKFCA RLNIQPRKPH VLSLHVHLMQ SENDYHLDWP FKGRIKLCMV HPADATLSQH 420
  421 DTIMTKPEIL AFHKPREAIS TRGFGFLEYA NISNIIQLGF CADDRLLIKI EINIV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..80] MSA 2.102995 View MSA. No confident structure predictions are available.
    2 View Details [81..196] PSI-BLAST 9.0 RAG1 DIMERIZATION DOMAIN
    3 View Details [197..288] deduced N/A No confident structure predictions are available.
    4 View Details [289..475] PSI-BLAST 36.39794 TNF receptor associated factor 3 (TRAF3); TRAF3

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  5.32809533104435 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  5.17943669371679 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  4.2482314105959 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  3.07217714843839 bayes_pls_golite062009
  • protein binding
    		•  2.64803540957326 bayes_pls_golite062009
  • binding
    		•  2.14721962003828 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.68475305605912 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.453159800244 bayes_pls_golite062009
  • ubiquitin-ubiquitin ligase activity
    		•  1.37401357060257 bayes_pls_golite062009
  • chromatin binding
    		•  1.30140469366308 bayes_pls_golite062009
  • DNA binding
    		•  1.04821660471647 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.73552256979331 bayes_pls_golite062009
  • small conjugating protein-specific protease activity
    		•  0.637551805535732 bayes_pls_golite062009
  • ligase activity
    		•  0.63517530468004 bayes_pls_golite062009
  • ubiquitin-specific protease activity
    		•  0.549461161056205 bayes_pls_golite062009
  • transcription activator activity
    		•  0.546784009980947 bayes_pls_golite062009
  • transcription factor activity
    		•  0.256724934540426 bayes_pls_golite062009
  • transcription factor binding
    		•  0.25479994691323 bayes_pls_golite062009
  • cysteine-type peptidase activity
    		•  0.159023519781458 bayes_pls_golite062009
  • catalytic activity
    		•  0.14112008370434 bayes_pls_golite062009
  • enzyme binding
    		•  0.104373352314595 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.0911606411674865 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.017536022609566 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle