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View Structure Prediction Details

Protein: Traf6-PA
Organism: Drosophila melanogaster
Length: 475 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Traf6-PA.

Description E-value Query
Range
Subject
Range
gi|5714383 - gi|5714383|gb|AAD47895.1|AF079838_1 TRAF6 [Drosophila melanogaster]
224.0 [0..1] [475..1]

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Predicted Domain #1
Region A:
Residues: [1-80]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQRVQADQKP ARMHQHAHTH SHAHSLQHAE EKEHNSNEMT TNLSSTGRIA ASSSATPSAA  60
   61 AGGGASGAPT PPKSLALNQN 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [81-196]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HHYAPGSDTS GEQEEELLDS RYECAICIDW LNEPVLTSCG HRFCRSCLTA WMQKNNQCCP  60
   61 MDNKRLSAEH DIFPDNYTRR EIEQLKRDCP NSSLGCSVVA SPIELHRHLP SCPYRR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.0
Match: 1rmdA
Description: RAG1 DIMERIZATION DOMAIN
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ubiquitin-protein ligase activity 5.32809533104435 bayes_pls_golite062009
small conjugating protein ligase activity 5.17943669371679 bayes_pls_golite062009
acid-amino acid ligase activity 4.2482314105959 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 3.07217714843839 bayes_pls_golite062009
protein binding 2.64803540957326 bayes_pls_golite062009
binding 2.14721962003828 bayes_pls_golite062009
transcription regulator activity 1.68475305605912 bayes_pls_golite062009
nucleic acid binding 1.453159800244 bayes_pls_golite062009
ubiquitin-ubiquitin ligase activity 1.37401357060257 bayes_pls_golite062009
chromatin binding 1.30140469366308 bayes_pls_golite062009
DNA binding 1.04821660471647 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.73552256979331 bayes_pls_golite062009
small conjugating protein-specific protease activity 0.637551805535732 bayes_pls_golite062009
ligase activity 0.63517530468004 bayes_pls_golite062009
ubiquitin-specific protease activity 0.549461161056205 bayes_pls_golite062009
transcription activator activity 0.546784009980947 bayes_pls_golite062009
transcription factor activity 0.256724934540426 bayes_pls_golite062009
transcription factor binding 0.25479994691323 bayes_pls_golite062009
cysteine-type peptidase activity 0.159023519781458 bayes_pls_golite062009
catalytic activity 0.14112008370434 bayes_pls_golite062009
enzyme binding 0.104373352314595 bayes_pls_golite062009
structure-specific DNA binding 0.0911606411674865 bayes_pls_golite062009
sequence-specific DNA binding 0.017536022609566 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [197-288]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QQEPQEEKCP FAKIKCDFVG RPETNQLEEH LKADMPHHMQ LMLQAFQQTA IATWQPHKPS  60
   61 TSGAAVENGH GQQQLPPPPQ YANGVDEQIV QT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [289-475]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYQRIVVLEQ RTREQETRLE NMQKQLRLAR QQAPVDPRYS NGTIVWRIEQ LGALVARLRA  60
   61 NANNQVYSHE CYTSPHGYKF CARLNIQPRK PHVLSLHVHL MQSENDYHLD WPFKGRIKLC 120
  121 MVHPADATLS QHDTIMTKPE ILAFHKPREA ISTRGFGFLE YANISNIIQL GFCADDRLLI 180
  181 KIEINIV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 36.39794
Match: 1kzzA
Description: TNF receptor associated factor 3 (TRAF3); TRAF3
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle