Protein Overview: Dscam-PAI

General Information:
Name(s) found:	Dscam-PAI / FBpp0110349 [FlyBase]
Description(s) found: Found 16 descriptions. SHOW ALL	The gene Down syndrome cell adhesion molecule is referred to in FlyBase by the symbol Dmel\Dscam (CG17800, FBgn0033159). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:3207059..3269374. It has the cytological map location 43A4-43B1. There is experimental evidence that it has the molecular function</span>: protein binding; bacterial binding; protein homodimerization activity; axon guidance receptor activity. There is experimental evidence that it is involved in the biological process</span>: dendrite self-avoidance; axon extension involved in axon guidance; axon guidance; phagocytosis; central nervous system morphogenesis; neuron development; axonal fasciculation; mushroom body development; peripheral nervous system development. 120 alleles are reported. The phenotypes of these alleles are annotated with 18 unique terms, many of which group under: nervous system; multi-cell-component structure; organ system; adult segment; embryonic nervous system; commissure; antennal segment; adult brain; peripheral nervous system; mushroom body. It has 59 annotated transcripts and 59 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	2017 amino acids
Gene Ontology:
Cellular Component:	integral to plasma membrane [ISS] dendrite [IDA] neuronal cell body [IDA] axon [IDA]
Biological Process:	mushroom body development [IMP] dendrite self-avoidance [IDA][IMP] phagocytosis [IMP] axon guidance [IGI][IMP][TAS] peripheral nervous system development [IMP] neuron development [IMP] central nervous system morphogenesis [IMP] axonal fasciculation [IMP] axon extension involved in axon guidance [IMP]
Molecular Function:	protein binding [IDA] protein homodimerization activity [IPI] axon guidance receptor activity [IMP][NAS] bacterial cell surface binding [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNMPNERLKW LMLFAAVALI ACGSQTLAAN PPDADQKGPV FLKEPTNRID FSNSTGAEIE  60
   61 CKASGNPMPE IIWIRSDGTA VGDVPGLRQI SSDGKLVFPP FRAEDYRQEV HAQVYACLAR 120
  121 NQFGSIISRD VHVRAVVNQF YEAEIMTEYV IRGNAAVLKC SIPSFVADFV RVESWIDDEG 180
  181 NVLSFSDNYD GKYLVLPSGE LHIREVGPED GYKSYQCRTK HRLTGETRLS ATKGRLVITE 240
  241 PVGTVSPKIS TGEDFKHLKG KSSQDLSILC PAQAYPQPFF RWYKFIEGTT RKQAVVLNDR 300
  301 VKQVSGTLII KDAVVEDSGK YLCVVNNSVG GESVETVLTV TAPLSAKIDP PTQTVDFGRP 360
  361 AVFTCQYTGN PIKTVSWMKD GKAIGHSEPV LRIESVKKED KGMYQCFVRN DQESAEASAE 420
  421 LKLGGRFDPP VIRQAFQEET MEPGPSVFLK CVAGGNPTPE ISWELDGKKI ANNDRYQVGQ 480
  481 YVTVNGDVVS YLNITSVHAN DGGLYKCIAK SKVGVAEHSA KLNVYGLPYI RQMEKKAIVA 540
  541 GETLIVTCPV AGYPIDSIVW ERDNRALPIN RKQKVFPNGT LIIENVERNS DQATYTCVAK 600
  601 NQEGYSARGS LEVQVMVPPS IAPFSFGDDP VNTGENAGVQ CMVQKGDVPI TIKWTLNSRP 660
  661 IINGEEGITI LKLSPKTSVL NIAAVEQDHR GVFKCIAENK AGSSFTTSEL KVNVPPRWIL 720
  721 EPTDKAFAQG SDAKVECKAD GFPKPQVTWK KAVGDTPGEY KDLKKSDNIR VEEGTLHVDN 780
  781 IQKTNEGYYL CEAINGIGSG LSAVIMISVQ APPEFTEKLR NQTARRGEPA VLQCEAKGEK 840
  841 PIGILWNMNN MRLDPKNDNR YTIREEILST GVMSSLSIKR TERSDSALFT CVATNAFGSD 900
  901 DASINMIVQE VPEMPYALKV LDKSGRSVQL SWAQPYDGNS PLDRYIIEFK RSRASWSEID 960
  961 RVIVPGHTTE AQVQKLSPAT TYNIRIVAEN AIGTSQSSEA VTIITAEEAP SGKPQNIKVE1020
 1021 PVNQTTMRVT WKPPPRTEWN GEILGYYVGY KLSNTNSSYV FETINFITEE GKEHNLELQN1080
 1081 LRVYTQYSVV IQAFNKIGAG PLSEEEKQFT AEGTPSQPPS DTACTTLTSQ TIRVGWVSPP1140
 1141 LESANGVIKT YKVVYAPSDE WYDETKRHYK KTASSDTVLH GLKKYTNYTM QVLATTAGGD1200
 1201 GVRSVPIHCQ TEPDVPEAPT DVKALVMGNA AILVSWRPPA QPNGIITQYT VYSKAEGAET1260
 1261 ETKTQKVPHY QMSFEATELE KNKPYEFWVT ASTTIGEGQQ SKSIVAMPSD QVPAKIASFD1320
 1321 DTFTATFKED AKMPCLAVGA PQPEITWKIK GVEFSANDRM RVLPDGSLLI KSVNRQDAGD1380
 1381 YSCHAENSIA KDSITHKLIV LAPPQSPHVT LSATTTDALT VKLKPHEGDT APLHGYTLHY1440
 1441 KPEFGEWETS EVSVDSQKHN IEGLLCGSRY QVYATGFNNI GAGEASDILN TRTKGQKPKL1500
 1501 PEKPRFIEVS SNSVSLHFKA WKDGGCPMSH FVVESKKRDQ IEWNQISNNV KPDNNYVVLD1560
 1561 LEPATWYNLR ITAHNSAGFT VAEYDFATLT VTGGTIAPSR DLPELSAEDT IRIILSNLNL1620
 1621 VVPVVAALLV IIIAIIVICI LRSKGNHHKD DVVYNQTMGP GATLDKRRPD LRDELGYIAP1680
 1681 PNRKLPPVPG SNYNTCDRIK RGRGGLRSNH STWDPRRNPN LYEELKAPPV PMHGNHYGHA1740
 1741 HGNAECHYRH PGMEDEICPY ATFHLLGFRE EMDPTKAMNF QTFPHQNGHA GPVPGHAGTM1800
 1801 LPPGHPGHVH SRSGSQSMPR ANRYQRKNSQ GGQSSIYTPA PEYDDPANCA EEDQYRRYTR1860
 1861 VNSQGGSLYS GPGPEYDDPA NCAPEEDQYG SQYGGPYGQP YDHYGSRGSM GRRSIGSARN1920
 1921 PGNGSPEPPP PPPRNHDMSN SSFNDSKESN EISEAECDRD HGPRGNYGAV KRSPQPKDQR1980
 1981 TTEEMRKLIE RNETGPKQLQ LQQANGAGFT AYDTMAV

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
telethonin binding	6.64811984458494	bayes_pls_golite062009
alpha-actinin binding	5.77350124471385	bayes_pls_golite062009
actinin binding	5.69539760434923	bayes_pls_golite062009
structural constituent of muscle	4.93896503565413	bayes_pls_golite062009
olfactory receptor activity	4.21057154107121	bayes_pls_golite062009
antigen binding	4.06466268219034	bayes_pls_golite062009
binding	3.17641566810715	bayes_pls_golite062009
receptor activity	3.0754311615326	bayes_pls_golite062009
peptide antigen binding	2.94721224577771	bayes_pls_golite062009
molecular transducer activity	2.92683710723714	bayes_pls_golite062009
signal transducer activity	2.92683710723714	bayes_pls_golite062009
fibroblast growth factor 1 binding	2.83860944503193	bayes_pls_golite062009
transmembrane receptor activity	2.79758224858792	bayes_pls_golite062009
protein binding	2.22855404705168	bayes_pls_golite062009
IgG binding	1.92633562075074	bayes_pls_golite062009
receptor binding	1.70260377709721	bayes_pls_golite062009
cytoskeletal protein binding	1.58610597245454	bayes_pls_golite062009
actin binding	1.42681407553255	bayes_pls_golite062009
cell adhesion molecule binding	1.36789541796983	bayes_pls_golite062009
protein kinase activity	1.36635494500222	bayes_pls_golite062009
nucleic acid binding	1.32330470851159	bayes_pls_golite062009
fibroblast growth factor binding	1.27793818082552	bayes_pls_golite062009
DNA binding	1.19412627500732	bayes_pls_golite062009
myosin light chain kinase activity	1.17845072849922	bayes_pls_golite062009
transcription regulator activity	1.16252234499274	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.02286631988334	bayes_pls_golite062009
kinase activity	0.929878054374821	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.878595022643164	bayes_pls_golite062009
fibroblast growth factor receptor activity	0.84475532395276	bayes_pls_golite062009
actin filament binding	0.760856470721016	bayes_pls_golite062009
growth factor binding	0.715053526402219	bayes_pls_golite062009
immunoglobulin binding	0.64138121404685	bayes_pls_golite062009
collagen binding	0.635057461053063	bayes_pls_golite062009
titin binding	0.599892148302011	bayes_pls_golite062009
integrin binding	0.599569390248921	bayes_pls_golite062009
structural molecule activity	0.567620977360967	bayes_pls_golite062009
protein serine/threonine kinase activity	0.564762108830441	bayes_pls_golite062009
transcription factor activity	0.54549168007511	bayes_pls_golite062009
myosin heavy chain binding	0.49788128784685	bayes_pls_golite062009
protein complex binding	0.43131084085213	bayes_pls_golite062009
protein tyrosine kinase activity	0.318890055375093	bayes_pls_golite062009
immunoglobulin receptor activity	0.117547357032989	bayes_pls_golite062009
structural constituent of cytoskeleton	0.0579247757286607	bayes_pls_golite062009
cell surface binding	0.0515688920405171	bayes_pls_golite062009

No functions predicted.

Source: Reynolds et al. 2008. Manuscript submitted

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..143]	PSI-BLAST	80.045757	No description for 2v5sA was found.
2	View Details	[144..255]	PSI-BLAST	11.30103	Immunoglobulin light chain kappa variable domain, VL-kappa; Immunoglobulin heavy chain variable domain, VH
3	View Details	[256..910]	PSI-BLAST	58.69897	Model of human carcinoembryonic antigen by homology modelling and curve-fitting to experimental solution scattering data
4	View Details	[911..997]	PSI-BLAST	36.0	No description for 2nziA was found.
5	View Details	[998..1111]	PSI-BLAST	11.221849	No description for 2edxA was found.
6	View Details	[1112..1583]	PSI-BLAST	24.0	No description for 2v5yA was found.
7	View Details	[1584..1805]	deduced	N/A	No confident structure predictions are available.
8	View Details	[1806..1921]	MSA	3.106995	View MSA. No confident structure predictions are available.
9	View Details	[1922..2017]	deduced	N/A	No confident structure predictions are available.

Protein Overview: Dscam-PAI

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: