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View Structure Prediction Details

Protein: Dscam-PAI
Organism: Drosophila melanogaster
Length: 2017 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Dscam-PAI.

Description E-value Query
Range
Subject
Range
Dscam-PAM - The gene Down syndrome cell adhesion molecule is referred to in FlyBase by the symbol Dmel\Dscam (CG...
1528.0 [0..3] [2017..3]

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Predicted Domain #1
Region A:
Residues: [1-143]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNMPNERLKW LMLFAAVALI ACGSQTLAAN PPDADQKGPV FLKEPTNRID FSNSTGAEIE  60
   61 CKASGNPMPE IIWIRSDGTA VGDVPGLRQI SSDGKLVFPP FRAEDYRQEV HAQVYACLAR 120
  121 NQFGSIISRD VHVRAVVNQF YEA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 80.045757
Match: 2v5sA
Description: No description for 2v5sA was found.

Predicted Domain #2
Region A:
Residues: [144-255]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EIMTEYVIRG NAAVLKCSIP SFVADFVRVE SWIDDEGNVL SFSDNYDGKY LVLPSGELHI  60
   61 REVGPEDGYK SYQCRTKHRL TGETRLSATK GRLVITEPVG TVSPKISTGE DF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.30103
Match: 1f3rB
Description: Immunoglobulin light chain kappa variable domain, VL-kappa; Immunoglobulin heavy chain variable domain, VH
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
telethonin binding 6.64811984458494 bayes_pls_golite062009
alpha-actinin binding 5.77350124471385 bayes_pls_golite062009
actinin binding 5.69539760434923 bayes_pls_golite062009
structural constituent of muscle 4.93896503565413 bayes_pls_golite062009
olfactory receptor activity 4.21057154107121 bayes_pls_golite062009
antigen binding 4.06466268219034 bayes_pls_golite062009
binding 3.17641566810715 bayes_pls_golite062009
receptor activity 3.0754311615326 bayes_pls_golite062009
peptide antigen binding 2.94721224577771 bayes_pls_golite062009
molecular transducer activity 2.92683710723714 bayes_pls_golite062009
signal transducer activity 2.92683710723714 bayes_pls_golite062009
fibroblast growth factor 1 binding 2.83860944503193 bayes_pls_golite062009
transmembrane receptor activity 2.79758224858792 bayes_pls_golite062009
protein binding 2.22855404705168 bayes_pls_golite062009
IgG binding 1.92633562075074 bayes_pls_golite062009
receptor binding 1.70260377709721 bayes_pls_golite062009
cytoskeletal protein binding 1.58610597245454 bayes_pls_golite062009
actin binding 1.42681407553255 bayes_pls_golite062009
cell adhesion molecule binding 1.36789541796983 bayes_pls_golite062009
protein kinase activity 1.36635494500222 bayes_pls_golite062009
nucleic acid binding 1.32330470851159 bayes_pls_golite062009
fibroblast growth factor binding 1.27793818082552 bayes_pls_golite062009
DNA binding 1.19412627500732 bayes_pls_golite062009
myosin light chain kinase activity 1.17845072849922 bayes_pls_golite062009
transcription regulator activity 1.16252234499274 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.02286631988334 bayes_pls_golite062009
kinase activity 0.929878054374821 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.878595022643164 bayes_pls_golite062009
fibroblast growth factor receptor activity 0.84475532395276 bayes_pls_golite062009
actin filament binding 0.760856470721016 bayes_pls_golite062009
growth factor binding 0.715053526402219 bayes_pls_golite062009
immunoglobulin binding 0.64138121404685 bayes_pls_golite062009
collagen binding 0.635057461053063 bayes_pls_golite062009
titin binding 0.599892148302011 bayes_pls_golite062009
integrin binding 0.599569390248921 bayes_pls_golite062009
structural molecule activity 0.567620977360967 bayes_pls_golite062009
protein serine/threonine kinase activity 0.564762108830441 bayes_pls_golite062009
transcription factor activity 0.54549168007511 bayes_pls_golite062009
myosin heavy chain binding 0.49788128784685 bayes_pls_golite062009
protein complex binding 0.43131084085213 bayes_pls_golite062009
protein tyrosine kinase activity 0.318890055375093 bayes_pls_golite062009
immunoglobulin receptor activity 0.117547357032989 bayes_pls_golite062009
structural constituent of cytoskeleton 0.0579247757286607 bayes_pls_golite062009
cell surface binding 0.0515688920405171 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [256-910]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KHLKGKSSQD LSILCPAQAY PQPFFRWYKF IEGTTRKQAV VLNDRVKQVS GTLIIKDAVV  60
   61 EDSGKYLCVV NNSVGGESVE TVLTVTAPLS AKIDPPTQTV DFGRPAVFTC QYTGNPIKTV 120
  121 SWMKDGKAIG HSEPVLRIES VKKEDKGMYQ CFVRNDQESA EASAELKLGG RFDPPVIRQA 180
  181 FQEETMEPGP SVFLKCVAGG NPTPEISWEL DGKKIANNDR YQVGQYVTVN GDVVSYLNIT 240
  241 SVHANDGGLY KCIAKSKVGV AEHSAKLNVY GLPYIRQMEK KAIVAGETLI VTCPVAGYPI 300
  301 DSIVWERDNR ALPINRKQKV FPNGTLIIEN VERNSDQATY TCVAKNQEGY SARGSLEVQV 360
  361 MVPPSIAPFS FGDDPVNTGE NAGVQCMVQK GDVPITIKWT LNSRPIINGE EGITILKLSP 420
  421 KTSVLNIAAV EQDHRGVFKC IAENKAGSSF TTSELKVNVP PRWILEPTDK AFAQGSDAKV 480
  481 ECKADGFPKP QVTWKKAVGD TPGEYKDLKK SDNIRVEEGT LHVDNIQKTN EGYYLCEAIN 540
  541 GIGSGLSAVI MISVQAPPEF TEKLRNQTAR RGEPAVLQCE AKGEKPIGIL WNMNNMRLDP 600
  601 KNDNRYTIRE EILSTGVMSS LSIKRTERSD SALFTCVATN AFGSDDASIN MIVQE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 58.69897
Match: 1e07A
Description: Model of human carcinoembryonic antigen by homology modelling and curve-fitting to experimental solution scattering data
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [911-997]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VPEMPYALKV LDKSGRSVQL SWAQPYDGNS PLDRYIIEFK RSRASWSEID RVIVPGHTTE  60
   61 AQVQKLSPAT TYNIRIVAEN AIGTSQS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 36.0
Match: 2nziA
Description: No description for 2nziA was found.

Predicted Domain #5
Region A:
Residues: [998-1111]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SEAVTIITAE EAPSGKPQNI KVEPVNQTTM RVTWKPPPRT EWNGEILGYY VGYKLSNTNS  60
   61 SYVFETINFI TEEGKEHNLE LQNLRVYTQY SVVIQAFNKI GAGPLSEEEK QFTA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.221849
Match: 2edxA
Description: No description for 2edxA was found.

Predicted Domain #6
Region A:
Residues: [1112-1583]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EGTPSQPPSD TACTTLTSQT IRVGWVSPPL ESANGVIKTY KVVYAPSDEW YDETKRHYKK  60
   61 TASSDTVLHG LKKYTNYTMQ VLATTAGGDG VRSVPIHCQT EPDVPEAPTD VKALVMGNAA 120
  121 ILVSWRPPAQ PNGIITQYTV YSKAEGAETE TKTQKVPHYQ MSFEATELEK NKPYEFWVTA 180
  181 STTIGEGQQS KSIVAMPSDQ VPAKIASFDD TFTATFKEDA KMPCLAVGAP QPEITWKIKG 240
  241 VEFSANDRMR VLPDGSLLIK SVNRQDAGDY SCHAENSIAK DSITHKLIVL APPQSPHVTL 300
  301 SATTTDALTV KLKPHEGDTA PLHGYTLHYK PEFGEWETSE VSVDSQKHNI EGLLCGSRYQ 360
  361 VYATGFNNIG AGEASDILNT RTKGQKPKLP EKPRFIEVSS NSVSLHFKAW KDGGCPMSHF 420
  421 VVESKKRDQI EWNQISNNVK PDNNYVVLDL EPATWYNLRI TAHNSAGFTV AE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 24.0
Match: 2v5yA
Description: No description for 2v5yA was found.

Predicted Domain #7
Region A:
Residues: [1584-1805]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YDFATLTVTG GTIAPSRDLP ELSAEDTIRI ILSNLNLVVP VVAALLVIII AIIVICILRS  60
   61 KGNHHKDDVV YNQTMGPGAT LDKRRPDLRD ELGYIAPPNR KLPPVPGSNY NTCDRIKRGR 120
  121 GGLRSNHSTW DPRRNPNLYE ELKAPPVPMH GNHYGHAHGN AECHYRHPGM EDEICPYATF 180
  181 HLLGFREEMD PTKAMNFQTF PHQNGHAGPV PGHAGTMLPP GH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [1806-1921]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PGHVHSRSGS QSMPRANRYQ RKNSQGGQSS IYTPAPEYDD PANCAEEDQY RRYTRVNSQG  60
   61 GSLYSGPGPE YDDPANCAPE EDQYGSQYGG PYGQPYDHYG SRGSMGRRSI GSARNP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #9
Region A:
Residues: [1922-2017]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNGSPEPPPP PPRNHDMSNS SFNDSKESNE ISEAECDRDH GPRGNYGAVK RSPQPKDQRT  60
   61 TEEMRKLIER NETGPKQLQL QQANGAGFTA YDTMAV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle