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Protein Overview: Dscam-PQ

General Information:
Name(s) found: Dscam-PQ / FBpp0110386 [FlyBase]
Description(s) found:
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  • gi|116007622|ref|NP_001036507.1| down syndrome cell adhesion molecule, isoform Q [Drosophila melanogaster] [NCBI NR]
  • gi|113194612|gb|ABI31058.1| down syndrome cell adhesion molecule, isoform Q [Drosophila melanogaster] [NCBI NR]
  • The gene Down syndrome cell adhesion molecule is referred to in FlyBase by the symbol Dmel\Dscam (CG17800, FBgn0033159). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:3207059..3269374. It has the cytological map location 43A4-43B1. There is experimental evidence that it has the molecular function</span>: protein binding; bacterial binding; protein homodimerization activity; axon guidance receptor activity. There is experimental evidence that it is involved in the biological process</span>: dendrite self-avoidance; axon extension involved in axon guidance; axon guidance; phagocytosis; central nervous system morphogenesis; neuron development; axonal fasciculation; mushroom body development; peripheral nervous system development. 120 alleles are reported. The phenotypes of these alleles are annotated with 18 unique terms, many of which group under: nervous system; multi-cell-component structure; organ system; adult segment; embryonic nervous system; commissure; antennal segment; adult brain; peripheral nervous system; mushroom body. It has 59 annotated transcripts and 59 annotated polypeptides. [FlyBase]
  • type=protein; loc=2R:complement(3230139..3230386,3235354..3235515,3235636..3236480,3247587..3247710,3249223..3249372,3253448..3253609,3255893..3256237,3265039..3265099); ID=FBpp0110386; name=Dscam-PQ; parent=FBgn0033159,FBtr0111091; dbxref=FlyBase:FBpp011 [fly-100309-contam.fasta]
  • CG17800-PQ, isoform Q [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Down syndrome cell adhesion molecule CG17800-PQ, isoform Q [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=2R:complement(3230139..3230386,3235354..3235515,3235636..3236480,3247587..3247710,3249223..3249372,3253448..3253609,3255893..3256237,3265039..3265099); ID=FBpp0110386; name=Dscam-PQ; parent=FBgn0033159,FBtr0111091; dbxref=FlyBase:FBpp0110386,FlyBase_Annotation_IDs:CG17800-PQ,REFSEQ:NP_001036507,GB_protein:ABI31058; MD5=ceb21657167cfa553c5ab12e31770193; length=698; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2R:complement(3230139..3230386,3235354..3235515,3235636..3236480,3247587..3247710,3249223..3249372,3253448..3253609,3255893..3256237,3265039..3265099); ID=FBpp0110386; name=Dscam-PQ; parent=FBgn0033159,FBtr0111091; dbxref=FlyBase:FBpp0110386,FlyBase_Annotation_IDs:CG17800-PQ,REFSEQ:NP_001036507,GB_protein:ABI31058; MD5=ceb21657167cfa553c5ab12e31770193; length=698; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Down syndrome cell adhesion molecule, isoform Q OS=Drosophila melanogaster GN=Dscam PE=4 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
    • Organism: Drosophila melanogaster
    Length: 698 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [ISS]
    dendrite [IDA]
    neuronal cell body [IDA]
    axon [IDA]
    Biological Process: mushroom body development [IMP]
    dendrite self-avoidance [IDA][IMP]
    phagocytosis [IMP]
    axon guidance [IGI][IMP][TAS]
    peripheral nervous system development [IMP]
    neuron development [IMP]
    central nervous system morphogenesis [IMP]
    axonal fasciculation [IMP]
    axon extension involved in axon guidance [IMP]
    Molecular Function: protein binding [IDA]
    protein homodimerization activity [IPI]
    axon guidance receptor activity [IMP][NAS]
    bacterial cell surface binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNMPNERLKW LMLFAAVALI ACGSQTLAAN PPDADQKGPV FLKEPTNRID FSNSTGAEIE  60
   61 CKASGNPMPE IIWIRSDGTA VGDVPGLRQI SSDGKLVFPP FRAEDYRQEV HAQVYACLAR 120
  121 NQFGSIISRD VHVRAVVAQY YDTDVNKAYV IRGNAAVLKC EIPSFVADFV SVVSWHTDQN 180
  181 EDFLPGSEYD GKYLVLPSGE LHIREVGPED GYKSYQCRTK HRLTGETRLS ATKGRLVITE 240
  241 PVGSIGPRLT SGDESRILRV YLAASATLLC PAQAYPVPFF RWYKFIEGTT RKQAVVLNDR 300
  301 VKQVSGTLII KDAVVEDSGK YLCVVNNSVG GESVETVLTV TAPLSAKIDP PTQTVDFGRP 360
  361 AVFTCQYTGN PIKTVSWMKD GKAIGHSEPV LRIESVKKED KGMYQCFVRN DQESAEASAE 420
  421 LKLGGRFDPP VIRQAFQEET MEPGPSVFLK CVAGGNPTPE ISWELDGKKI ANNDRYQVGQ 480
  481 YVTVNGDVVS YLNITSVHAN DGGLYKCIAK SKVGVAEHSA KLNVYGLPYI RQMEKKAIVA 540
  541 GETLIVTCPV AGYPIDSIVW ERDNRALPIN RKQKVFPNGT LIIENVERNS DQATYTCVAK 600
  601 NQEGYSARGS LEVQVMVLPQ IVPFAYEDLI NMGDSIDLFC QIQKGDRPIK VHWSFERSAG 660
  661 DYGFDQVQPQ MRTNRISEKT SMISIPSASP AHTGRIPV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..246] PSI-BLAST 94.522879 No description for 2v5sA was found.
    2 View Details [247..617] PSI-BLAST 20.69897 Immunoglobulin heavy chain variable domain, VH; Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma; Immunoglobulin heavy chain gamma constant domain 2, CH2-gamma; Immunoglobulin heavy chain gamma constant domain 3, CH3-gamma
    3 View Details [618..698] FFAS03 3.93 TITIN MODULE M5, N-TERMINALLY EXTENDED, NMR

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • telethonin binding
    		•  6.64811984458494 bayes_pls_golite062009
  • alpha-actinin binding
    		•  5.77350124471385 bayes_pls_golite062009
  • actinin binding
    		•  5.69539760434923 bayes_pls_golite062009
  • structural constituent of muscle
    		•  4.93896503565413 bayes_pls_golite062009
  • antigen binding
    		•  4.06466268219034 bayes_pls_golite062009
  • binding
    		•  3.17641566810715 bayes_pls_golite062009
  • receptor activity
    		•  2.6260148704617 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.26083981067854 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.26075587783872 bayes_pls_golite062009
  • signal transducer activity
    		•  2.26075587783872 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.58610597245454 bayes_pls_golite062009
  • actin binding
    		•  1.42681407553255 bayes_pls_golite062009
  • peptide antigen binding
    		•  1.32632044811608 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.32330470851159 bayes_pls_golite062009
  • fibroblast growth factor 1 binding
    		•  1.24415316737453 bayes_pls_golite062009
  • DNA binding
    		•  1.19412627500732 bayes_pls_golite062009
  • protein binding
    		•  1.17809977833322 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.16252234499274 bayes_pls_golite062009
  • myosin light chain kinase activity
    		•  0.87238163212 bayes_pls_golite062009
  • receptor binding
    		•  0.838643016003073 bayes_pls_golite062009
  • actin filament binding
    		•  0.760856470721016 bayes_pls_golite062009
  • IgG binding
    		•  0.68435857661103 bayes_pls_golite062009
  • myosin heavy chain binding
    		•  0.66378995104464 bayes_pls_golite062009
  • titin binding
    		•  0.599892148302011 bayes_pls_golite062009
  • protein kinase activity
    		•  0.589015157128768 bayes_pls_golite062009
  • transcription factor activity
    		•  0.54549168007511 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  0.51084773288725 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  0.5037774536831 bayes_pls_golite062009
  • olfactory receptor activity
    		•  0.44769371137055 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.300034766861208 bayes_pls_golite062009
  • protein complex binding
    		•  0.24709070548365 bayes_pls_golite062009
  • kinase activity
    		•  0.232190923918901 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.182775558017364 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.0579247757286607 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.026512949804781 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.00722693352608417 bayes_pls_golite062009
  • structural molecule activity
    		•  0.00139730528977644 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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