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View Structure Prediction Details

Protein: Dscam-PQ
Organism: Drosophila melanogaster
Length: 698 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Dscam-PQ.

Description E-value Query
Range		 Subject
Range
Dscam-PN - The gene Down syndrome cell adhesion molecule is referred to in FlyBase by the symbol Dmel\Dscam (CG...
 609.0 [0..1] [698..1]

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Predicted Domain #1
Region A:
Residues: [1-246] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNMPNERLKW LMLFAAVALI ACGSQTLAAN PPDADQKGPV FLKEPTNRID FSNSTGAEIE  60
   61 CKASGNPMPE IIWIRSDGTA VGDVPGLRQI SSDGKLVFPP FRAEDYRQEV HAQVYACLAR 120
  121 NQFGSIISRD VHVRAVVAQY YDTDVNKAYV IRGNAAVLKC EIPSFVADFV SVVSWHTDQN 180
  181 EDFLPGSEYD GKYLVLPSGE LHIREVGPED GYKSYQCRTK HRLTGETRLS ATKGRLVITE 240
  241 PVGSIG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 94.522879
Match: 2v5sA
Description: No description for 2v5sA was found.

Predicted Domain #2
Region A:
Residues: [247-617] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PRLTSGDESR ILRVYLAASA TLLCPAQAYP VPFFRWYKFI EGTTRKQAVV LNDRVKQVSG  60
   61 TLIIKDAVVE DSGKYLCVVN NSVGGESVET VLTVTAPLSA KIDPPTQTVD FGRPAVFTCQ 120
  121 YTGNPIKTVS WMKDGKAIGH SEPVLRIESV KKEDKGMYQC FVRNDQESAE ASAELKLGGR 180
  181 FDPPVIRQAF QEETMEPGPS VFLKCVAGGN PTPEISWELD GKKIANNDRY QVGQYVTVNG 240
  241 DVVSYLNITS VHANDGGLYK CIAKSKVGVA EHSAKLNVYG LPYIRQMEKK AIVAGETLIV 300
  301 TCPVAGYPID SIVWERDNRA LPINRKQKVF PNGTLIIENV ERNSDQATYT CVAKNQEGYS 360
  361 ARGSLEVQVM V

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 20.69897
Match: 1mcoH
Description: Immunoglobulin heavy chain variable domain, VH; Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma; Immunoglobulin heavy chain gamma constant domain 2, CH2-gamma; Immunoglobulin heavy chain gamma constant domain 3, CH3-gamma
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
telethonin binding 6.64811984458494 bayes_pls_golite062009
alpha-actinin binding 5.77350124471385 bayes_pls_golite062009
actinin binding 5.69539760434923 bayes_pls_golite062009
structural constituent of muscle 4.93896503565413 bayes_pls_golite062009
antigen binding 4.06466268219034 bayes_pls_golite062009
binding 3.17641566810715 bayes_pls_golite062009
receptor activity 2.6260148704617 bayes_pls_golite062009
transmembrane receptor activity 2.26083981067854 bayes_pls_golite062009
molecular transducer activity 2.26075587783872 bayes_pls_golite062009
signal transducer activity 2.26075587783872 bayes_pls_golite062009
cytoskeletal protein binding 1.58610597245454 bayes_pls_golite062009
actin binding 1.42681407553255 bayes_pls_golite062009
peptide antigen binding 1.32632044811608 bayes_pls_golite062009
nucleic acid binding 1.32330470851159 bayes_pls_golite062009
fibroblast growth factor 1 binding 1.24415316737453 bayes_pls_golite062009
DNA binding 1.19412627500732 bayes_pls_golite062009
protein binding 1.17809977833322 bayes_pls_golite062009
transcription regulator activity 1.16252234499274 bayes_pls_golite062009
myosin light chain kinase activity 0.87238163212 bayes_pls_golite062009
receptor binding 0.838643016003073 bayes_pls_golite062009
actin filament binding 0.760856470721016 bayes_pls_golite062009
IgG binding 0.68435857661103 bayes_pls_golite062009
myosin heavy chain binding 0.66378995104464 bayes_pls_golite062009
titin binding 0.599892148302011 bayes_pls_golite062009
protein kinase activity 0.589015157128768 bayes_pls_golite062009
transcription factor activity 0.54549168007511 bayes_pls_golite062009
G-protein coupled receptor activity 0.51084773288725 bayes_pls_golite062009
fibroblast growth factor receptor activity 0.5037774536831 bayes_pls_golite062009
olfactory receptor activity 0.44769371137055 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.300034766861208 bayes_pls_golite062009
protein complex binding 0.24709070548365 bayes_pls_golite062009
kinase activity 0.232190923918901 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.182775558017364 bayes_pls_golite062009
structural constituent of cytoskeleton 0.0579247757286607 bayes_pls_golite062009
protein serine/threonine kinase activity 0.026512949804781 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.00722693352608417 bayes_pls_golite062009
structural molecule activity 0.00139730528977644 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [618-698] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPQIVPFAYE DLINMGDSID LFCQIQKGDR PIKVHWSFER SAGDYGFDQV QPQMRTNRIS  60
   61 EKTSMISIPS ASPAHTGRIP V

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.93
Match: 1nctA
Description: TITIN MODULE M5, N-TERMINALLY EXTENDED, NMR
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle