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Protein Overview: Dscam-PAJ

General Information:
Name(s) found: Dscam-PAJ / FBpp0110350 [FlyBase]
Description(s) found:
Found 16 descriptions.
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  • The gene Down syndrome cell adhesion molecule is referred to in FlyBase by the symbol Dmel\Dscam (CG17800, FBgn0033159). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:3207059..3269374. It has the cytological map location 43A4-43B1. There is experimental evidence that it has the molecular function</span>: protein binding; bacterial binding; protein homodimerization activity; axon guidance receptor activity. There is experimental evidence that it is involved in the biological process</span>: dendrite self-avoidance; axon extension involved in axon guidance; axon guidance; phagocytosis; central nervous system morphogenesis; neuron development; axonal fasciculation; mushroom body development; peripheral nervous system development. 120 alleles are reported. The phenotypes of these alleles are annotated with 18 unique terms, many of which group under: nervous system; multi-cell-component structure; organ system; adult segment; embryonic nervous system; commissure; antennal segment; adult brain; peripheral nervous system; mushroom body. It has 59 annotated transcripts and 59 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 2030 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [ISS]
    dendrite [IDA]
    neuronal cell body [IDA]
    axon [IDA]
    Biological Process: mushroom body development [IMP]
    dendrite self-avoidance [IDA][IMP]
    phagocytosis [IMP]
    axon guidance [IGI][IMP][TAS]
    peripheral nervous system development [IMP]
    neuron development [IMP]
    central nervous system morphogenesis [IMP]
    axonal fasciculation [IMP]
    axon extension involved in axon guidance [IMP]
    Molecular Function: protein binding [IDA]
    protein homodimerization activity [IPI]
    axon guidance receptor activity [IMP][NAS]
    bacterial cell surface binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNMPNERLKW LMLFAAVALI ACGSQTLAAN PPDADQKGPV FLKEPTNRID FSNSTGAEIE  60
   61 CKASGNPMPE IIWIRSDGTA VGDVPGLRQI SSDGKLVFPP FRAEDYRQEV HAQVYACLAR 120
  121 NQFGSIISRD VHVRAVVNQF YEAEIMTEYV IRGNAAVLKC SIPSFVADFV RVESWIDDEG 180
  181 NVLSFSDNYD GKYLVLPSGE LHIREVGPED GYKSYQCRTK HRLTGETRLS ATKGRLVITE 240
  241 PIGSVSPKIS NSDDLKHVKV KRLLSLSLLC PAQAYPQPIS RWYKFIEGTT RKQAVVLNDR 300
  301 VKQVSGTLII KDAVVEDSGK YLCVVNNSVG GESVETVLTV TAPLSAKIDP PTQTVDFGRP 360
  361 AVFTCQYTGN PIKTVSWMKD GKAIGHSEPV LRIESVKKED KGMYQCFVRN DQESAEASAE 420
  421 LKLGGRFDPP VIRQAFQEET MEPGPSVFLK CVAGGNPTPE ISWELDGKKI ANNDRYQVGQ 480
  481 YVTVNGDVVS YLNITSVHAN DGGLYKCIAK SKVGVAEHSA KLNVYGLPYI RQMEKKAIVA 540
  541 GETLIVTCPV AGYPIDSIVW ERDNRALPIN RKQKVFPNGT LIIENVERNS DQATYTCVAK 600
  601 NQEGYSARGS LEVQVMVLPS IHPFSFDAEA NEGDSVQLTC HVAKGDLPLR IRWTHNGLPL 660
  661 FTHLGVMASK IGERISLLTV ESVKAANSGN YSCVASNNAG NVSSSAELLV NVPPRWILEP 720
  721 TDKAFAQGSD AKVECKADGF PKPQVTWKKA VGDTPGEYKD LKKSDNIRVE EGTLHVDNIQ 780
  781 KTNEGYYLCE AINGIGSGLS AVIMISVQAP PEFTEKLRNQ TARRGEPAVL QCEAKGEKPI 840
  841 GILWNMNNMR LDPKNDNRYT IREEILSTGV MSSLSIKRTE RSDSALFTCV ATNAFGSDDA 900
  901 SINMIVQEVP EMPYALKVLD KSGRSVQLSW AQPYDGNSPL DRYIIEFKRS RASWSEIDRV 960
  961 IVPGHTTEAQ VQKLSPATTY NIRIVAENAI GTSQSSEAVT IITAEEAPSG KPQNIKVEPV1020
 1021 NQTTMRVTWK PPPRTEWNGE ILGYYVGYKL SNTNSSYVFE TINFITEEGK EHNLELQNLR1080
 1081 VYTQYSVVIQ AFNKIGAGPL SEEEKQFTAE GTPSQPPSDT ACTTLTSQTI RVGWVSPPLE1140
 1141 SANGVIKTYK VVYAPSDEWY DETKRHYKKT ASSDTVLHGL KKYTNYTMQV LATTAGGDGV1200
 1201 RSVPIHCQTE PDVPEAPTDV KALVMGNAAI LVSWRPPAQP NGIITQYTVY SKAEGAETET1260
 1261 KTQKVPHYQM SFEATELEKN KPYEFWVTAS TTIGEGQQSK SIVAMPSDQV PAKIASFDDT1320
 1321 FTATFKEDAK MPCLAVGAPQ PEITWKIKGV EFSANDRMRV LPDGSLLIKS VNRQDAGDYS1380
 1381 CHAENSIAKD SITHKLIVLA PPQSPHVTLS ATTTDALTVK LKPHEGDTAP LHGYTLHYKP1440
 1441 EFGEWETSEV SVDSQKHNIE GLLCGSRYQV YATGFNNIGA GEASDILNTR TKGQKPKLPE1500
 1501 KPRFIEVSSN SVSLHFKAWK DGGCPMSHFV VESKKRDQIE WNQISNNVKP DNNYVVLDLE1560
 1561 PATWYNLRIT AHNSAGFTVA EYDFATLTVT GGTIAPLDDG SGHGNVHTRI RLPAWMPEWL1620
 1621 DLNFMVPLIA TVVVVAVGIC VVCVALSRRR ADDMRGGQKD VYYDVVYNQT MGPGATLDKR1680
 1681 RPDLRDELGY IAPPNRKLPP VPGSNYNTCD RIKRGRGGLR SNHSTWDPRR NPNLYEELKA1740
 1741 PPVPMHGNHY GHAHGNAECH YRHPGMEDEI CPYATFHLLG FREEMDPTKA MNFQTFPHQN1800
 1801 GHAGPVPGHA GTMLPPGHPG HVHSRSGSQS MPRANRYQRK NSQGGQSSIY TPAPEYDDPA1860
 1861 NCAEEDQYRR YTRVNSQGGS LYSGPGPEYD DPANCAPEED QYGSQYGGPY GQPYDHYGSR1920
 1921 GSMGRRSIGS ARNPGNGSPE PPPPPPRNHD MSNSSFNDSK ESNEISEAEC DRDHGPRGNY1980
 1981 GAVKRSPQPK DQRTTEEMRK LIERNETGPK QLQLQQANGA GFTAYDTMAV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..140] PSI-BLAST 78.522879 No description for 2v5sA was found.
    2 View Details [141..251] FFAS03 4.22 No description for 2eo9A was found.
    3 View Details [252..526] PSI-BLAST 19.522879 Type-1 interleukin-1 receptor
    4 View Details [527..619] PSI-BLAST 33.69897 No description for 2v9qA was found.
    5 View Details [620..712] PSI-BLAST 30.522879 No description for 2iepA was found.
    6 View Details [713..855] PSI-BLAST 26.522879 Crystal structure of the titin domains z1z2 in complex with telethonin
    7 View Details [856..1368] PSI-BLAST 28.0 No description for 2v5yA was found.
    8 View Details [1369..1594] PSI-BLAST 25.69897 FRAGMENT OF HUMAN FIBRONECTIN ENCOMPASSING TYPE-III REPEATS 7 THROUGH 10
    9 View Details [1595..1839] deduced N/A No confident structure predictions are available.
    10 View Details [1840..2030] MSA 1.122995 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • telethonin binding
    		•  6.64811984458494 bayes_pls_golite062009
  • alpha-actinin binding
    		•  5.77350124471385 bayes_pls_golite062009
  • actinin binding
    		•  5.69539760434923 bayes_pls_golite062009
  • structural constituent of muscle
    		•  4.93896503565413 bayes_pls_golite062009
  • olfactory receptor activity
    		•  4.21057154107121 bayes_pls_golite062009
  • antigen binding
    		•  4.06466268219034 bayes_pls_golite062009
  • receptor activity
    		•  4.00123250685257 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  3.81769911097805 bayes_pls_golite062009
  • peptide antigen binding
    		•  3.67780971105726 bayes_pls_golite062009
  • binding
    		•  3.17641566810715 bayes_pls_golite062009
  • signal transducer activity
    		•  3.10913345555941 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.10913345555941 bayes_pls_golite062009
  • fibroblast growth factor 1 binding
    		•  2.97046805846847 bayes_pls_golite062009
  • IgG binding
    		•  2.62006935586983 bayes_pls_golite062009
  • protein binding
    		•  2.22855404705168 bayes_pls_golite062009
  • IgE binding
    		•  1.73481096568834 bayes_pls_golite062009
  • IgE receptor activity
    		•  1.73481096568834 bayes_pls_golite062009
  • receptor binding
    		•  1.70260377709721 bayes_pls_golite062009
  • growth factor binding
    		•  1.60826091835429 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.58610597245454 bayes_pls_golite062009
  • actin binding
    		•  1.42681407553255 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  1.36789541796983 bayes_pls_golite062009
  • protein kinase activity
    		•  1.36635494500222 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.32330470851159 bayes_pls_golite062009
  • fibroblast growth factor binding
    		•  1.27793818082552 bayes_pls_golite062009
  • DNA binding
    		•  1.19412627500732 bayes_pls_golite062009
  • myosin light chain kinase activity
    		•  1.17845072849922 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.16252234499274 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  1.02428106476324 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.02286631988334 bayes_pls_golite062009
  • kinase activity
    		•  0.929878054374821 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.878595022643164 bayes_pls_golite062009
  • protein complex binding
    		•  0.83543827718565 bayes_pls_golite062009
  • actin filament binding
    		•  0.760856470721016 bayes_pls_golite062009
  • peptide binding
    		•  0.729048089532569 bayes_pls_golite062009
  • collagen binding
    		•  0.635057461053063 bayes_pls_golite062009
  • cytokine binding
    		•  0.631436442105379 bayes_pls_golite062009
  • titin binding
    		•  0.599892148302011 bayes_pls_golite062009
  • integrin binding
    		•  0.599569390248921 bayes_pls_golite062009
  • structural molecule activity
    		•  0.567620977360967 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.564762108830441 bayes_pls_golite062009
  • transcription factor activity
    		•  0.54549168007511 bayes_pls_golite062009
  • IgG receptor activity
    		•  0.50231877534761 bayes_pls_golite062009
  • myosin heavy chain binding
    		•  0.49788128784685 bayes_pls_golite062009
  • immunoglobulin receptor activity
    		•  0.45286767588665 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.447829399094714 bayes_pls_golite062009
  • cytokine receptor activity
    		•  0.34165331857492 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  0.318890055375093 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.28309679787333 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.0579247757286607 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.
    10 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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