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View Structure Prediction Details

Protein: Dscam-PAJ
Organism: Drosophila melanogaster
Length: 2030 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Dscam-PAJ.

Description E-value Query
Range
Subject
Range
Dscam-PAO - The gene Down syndrome cell adhesion molecule is referred to in FlyBase by the symbol Dmel\Dscam (CG...
1541.0 [0..3] [2030..3]

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Predicted Domain #1
Region A:
Residues: [1-140]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNMPNERLKW LMLFAAVALI ACGSQTLAAN PPDADQKGPV FLKEPTNRID FSNSTGAEIE  60
   61 CKASGNPMPE IIWIRSDGTA VGDVPGLRQI SSDGKLVFPP FRAEDYRQEV HAQVYACLAR 120
  121 NQFGSIISRD VHVRAVVNQF 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 78.522879
Match: 2v5sA
Description: No description for 2v5sA was found.

Predicted Domain #2
Region A:
Residues: [141-251]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YEAEIMTEYV IRGNAAVLKC SIPSFVADFV RVESWIDDEG NVLSFSDNYD GKYLVLPSGE  60
   61 LHIREVGPED GYKSYQCRTK HRLTGETRLS ATKGRLVITE PIGSVSPKIS N

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.22
Match: 2eo9A
Description: No description for 2eo9A was found.

Predicted Domain #3
Region A:
Residues: [252-526]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SDDLKHVKVK RLLSLSLLCP AQAYPQPISR WYKFIEGTTR KQAVVLNDRV KQVSGTLIIK  60
   61 DAVVEDSGKY LCVVNNSVGG ESVETVLTVT APLSAKIDPP TQTVDFGRPA VFTCQYTGNP 120
  121 IKTVSWMKDG KAIGHSEPVL RIESVKKEDK GMYQCFVRND QESAEASAEL KLGGRFDPPV 180
  181 IRQAFQEETM EPGPSVFLKC VAGGNPTPEI SWELDGKKIA NNDRYQVGQY VTVNGDVVSY 240
  241 LNITSVHAND GGLYKCIAKS KVGVAEHSAK LNVYG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.522879
Match: 1iraY
Description: Type-1 interleukin-1 receptor
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
telethonin binding 6.64811984458494 bayes_pls_golite062009
alpha-actinin binding 5.77350124471385 bayes_pls_golite062009
actinin binding 5.69539760434923 bayes_pls_golite062009
structural constituent of muscle 4.93896503565413 bayes_pls_golite062009
olfactory receptor activity 4.21057154107121 bayes_pls_golite062009
antigen binding 4.06466268219034 bayes_pls_golite062009
receptor activity 4.00123250685257 bayes_pls_golite062009
transmembrane receptor activity 3.81769911097805 bayes_pls_golite062009
peptide antigen binding 3.67780971105726 bayes_pls_golite062009
binding 3.17641566810715 bayes_pls_golite062009
signal transducer activity 3.10913345555941 bayes_pls_golite062009
molecular transducer activity 3.10913345555941 bayes_pls_golite062009
fibroblast growth factor 1 binding 2.97046805846847 bayes_pls_golite062009
IgG binding 2.62006935586983 bayes_pls_golite062009
protein binding 2.22855404705168 bayes_pls_golite062009
IgE binding 1.73481096568834 bayes_pls_golite062009
IgE receptor activity 1.73481096568834 bayes_pls_golite062009
receptor binding 1.70260377709721 bayes_pls_golite062009
growth factor binding 1.60826091835429 bayes_pls_golite062009
cytoskeletal protein binding 1.58610597245454 bayes_pls_golite062009
actin binding 1.42681407553255 bayes_pls_golite062009
cell adhesion molecule binding 1.36789541796983 bayes_pls_golite062009
protein kinase activity 1.36635494500222 bayes_pls_golite062009
nucleic acid binding 1.32330470851159 bayes_pls_golite062009
fibroblast growth factor binding 1.27793818082552 bayes_pls_golite062009
DNA binding 1.19412627500732 bayes_pls_golite062009
myosin light chain kinase activity 1.17845072849922 bayes_pls_golite062009
transcription regulator activity 1.16252234499274 bayes_pls_golite062009
G-protein coupled receptor activity 1.02428106476324 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.02286631988334 bayes_pls_golite062009
kinase activity 0.929878054374821 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.878595022643164 bayes_pls_golite062009
protein complex binding 0.83543827718565 bayes_pls_golite062009
actin filament binding 0.760856470721016 bayes_pls_golite062009
peptide binding 0.729048089532569 bayes_pls_golite062009
collagen binding 0.635057461053063 bayes_pls_golite062009
cytokine binding 0.631436442105379 bayes_pls_golite062009
titin binding 0.599892148302011 bayes_pls_golite062009
integrin binding 0.599569390248921 bayes_pls_golite062009
structural molecule activity 0.567620977360967 bayes_pls_golite062009
protein serine/threonine kinase activity 0.564762108830441 bayes_pls_golite062009
transcription factor activity 0.54549168007511 bayes_pls_golite062009
IgG receptor activity 0.50231877534761 bayes_pls_golite062009
myosin heavy chain binding 0.49788128784685 bayes_pls_golite062009
immunoglobulin receptor activity 0.45286767588665 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.447829399094714 bayes_pls_golite062009
cytokine receptor activity 0.34165331857492 bayes_pls_golite062009
protein tyrosine kinase activity 0.318890055375093 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 0.28309679787333 bayes_pls_golite062009
structural constituent of cytoskeleton 0.0579247757286607 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [527-619]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPYIRQMEKK AIVAGETLIV TCPVAGYPID SIVWERDNRA LPINRKQKVF PNGTLIIENV  60
   61 ERNSDQATYT CVAKNQEGYS ARGSLEVQVM VLP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 33.69897
Match: 2v9qA
Description: No description for 2v9qA was found.

Predicted Domain #5
Region A:
Residues: [620-712]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SIHPFSFDAE ANEGDSVQLT CHVAKGDLPL RIRWTHNGLP LFTHLGVMAS KIGERISLLT  60
   61 VESVKAANSG NYSCVASNNA GNVSSSAELL VNV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 30.522879
Match: 2iepA
Description: No description for 2iepA was found.

Predicted Domain #6
Region A:
Residues: [713-855]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPRWILEPTD KAFAQGSDAK VECKADGFPK PQVTWKKAVG DTPGEYKDLK KSDNIRVEEG  60
   61 TLHVDNIQKT NEGYYLCEAI NGIGSGLSAV IMISVQAPPE FTEKLRNQTA RRGEPAVLQC 120
  121 EAKGEKPIGI LWNMNNMRLD PKN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 26.522879
Match: 1ya5A
Description: Crystal structure of the titin domains z1z2 in complex with telethonin
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [856-1368]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DNRYTIREEI LSTGVMSSLS IKRTERSDSA LFTCVATNAF GSDDASINMI VQEVPEMPYA  60
   61 LKVLDKSGRS VQLSWAQPYD GNSPLDRYII EFKRSRASWS EIDRVIVPGH TTEAQVQKLS 120
  121 PATTYNIRIV AENAIGTSQS SEAVTIITAE EAPSGKPQNI KVEPVNQTTM RVTWKPPPRT 180
  181 EWNGEILGYY VGYKLSNTNS SYVFETINFI TEEGKEHNLE LQNLRVYTQY SVVIQAFNKI 240
  241 GAGPLSEEEK QFTAEGTPSQ PPSDTACTTL TSQTIRVGWV SPPLESANGV IKTYKVVYAP 300
  301 SDEWYDETKR HYKKTASSDT VLHGLKKYTN YTMQVLATTA GGDGVRSVPI HCQTEPDVPE 360
  361 APTDVKALVM GNAAILVSWR PPAQPNGIIT QYTVYSKAEG AETETKTQKV PHYQMSFEAT 420
  421 ELEKNKPYEF WVTASTTIGE GQQSKSIVAM PSDQVPAKIA SFDDTFTATF KEDAKMPCLA 480
  481 VGAPQPEITW KIKGVEFSAN DRMRVLPDGS LLI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 28.0
Match: 2v5yA
Description: No description for 2v5yA was found.

Predicted Domain #8
Region A:
Residues: [1369-1594]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KSVNRQDAGD YSCHAENSIA KDSITHKLIV LAPPQSPHVT LSATTTDALT VKLKPHEGDT  60
   61 APLHGYTLHY KPEFGEWETS EVSVDSQKHN IEGLLCGSRY QVYATGFNNI GAGEASDILN 120
  121 TRTKGQKPKL PEKPRFIEVS SNSVSLHFKA WKDGGCPMSH FVVESKKRDQ IEWNQISNNV 180
  181 KPDNNYVVLD LEPATWYNLR ITAHNSAGFT VAEYDFATLT VTGGTI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 25.69897
Match: 1fnfA
Description: FRAGMENT OF HUMAN FIBRONECTIN ENCOMPASSING TYPE-III REPEATS 7 THROUGH 10
Matching Structure (courtesy of the PDB):

Predicted Domain #9
Region A:
Residues: [1595-1839]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 APLDDGSGHG NVHTRIRLPA WMPEWLDLNF MVPLIATVVV VAVGICVVCV ALSRRRADDM  60
   61 RGGQKDVYYD VVYNQTMGPG ATLDKRRPDL RDELGYIAPP NRKLPPVPGS NYNTCDRIKR 120
  121 GRGGLRSNHS TWDPRRNPNL YEELKAPPVP MHGNHYGHAH GNAECHYRHP GMEDEICPYA 180
  181 TFHLLGFREE MDPTKAMNFQ TFPHQNGHAG PVPGHAGTML PPGHPGHVHS RSGSQSMPRA 240
  241 NRYQR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #10
Region A:
Residues: [1840-2030]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KNSQGGQSSI YTPAPEYDDP ANCAEEDQYR RYTRVNSQGG SLYSGPGPEY DDPANCAPEE  60
   61 DQYGSQYGGP YGQPYDHYGS RGSMGRRSIG SARNPGNGSP EPPPPPPRNH DMSNSSFNDS 120
  121 KESNEISEAE CDRDHGPRGN YGAVKRSPQP KDQRTTEEMR KLIERNETGP KQLQLQQANG 180
  181 AGFTAYDTMA V

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle