Protein Overview: Dscam-PV

General Information:
Name(s) found:	Dscam-PV / FBpp0110391 [FlyBase]
Description(s) found: Found 16 descriptions. SHOW ALL	The gene Down syndrome cell adhesion molecule is referred to in FlyBase by the symbol Dmel\Dscam (CG17800, FBgn0033159). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:3207059..3269374. It has the cytological map location 43A4-43B1. There is experimental evidence that it has the molecular function</span>: protein binding; bacterial binding; protein homodimerization activity; axon guidance receptor activity. There is experimental evidence that it is involved in the biological process</span>: dendrite self-avoidance; axon extension involved in axon guidance; axon guidance; phagocytosis; central nervous system morphogenesis; neuron development; axonal fasciculation; mushroom body development; peripheral nervous system development. 120 alleles are reported. The phenotypes of these alleles are annotated with 18 unique terms, many of which group under: nervous system; multi-cell-component structure; organ system; adult segment; embryonic nervous system; commissure; antennal segment; adult brain; peripheral nervous system; mushroom body. It has 59 annotated transcripts and 59 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	2016 amino acids
Gene Ontology:
Cellular Component:	integral to plasma membrane [ISS] dendrite [IDA] neuronal cell body [IDA] axon [IDA]
Biological Process:	mushroom body development [IMP] dendrite self-avoidance [IDA][IMP] phagocytosis [IMP] axon guidance [IGI][IMP][TAS] peripheral nervous system development [IMP] neuron development [IMP] central nervous system morphogenesis [IMP] axonal fasciculation [IMP] axon extension involved in axon guidance [IMP]
Molecular Function:	protein binding [IDA] protein homodimerization activity [IPI] axon guidance receptor activity [IMP][NAS] bacterial cell surface binding [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNMPNERLKW LMLFAAVALI ACGSQTLAAN PPDADQKGPV FLKEPTNRID FSNSTGAEIE  60
   61 CKASGNPMPE IIWIRSDGTA VGDVPGLRQI SSDGKLVFPP FRAEDYRQEV HAQVYACLAR 120
  121 NQFGSIISRD VHVRAVVAQY YDTDVNKAYV IRGNAAVLKC EIPSFVADFV SVVSWHTDQN 180
  181 EDFLPGSEYD GKYLVLPSGE LHIREVGPED GYKSYQCRTK HRLTGETRLS ATKGRLVITE 240
  241 PIGSKAPSVP TGVMVFQQQV PLLSTFAMLC QAQAFPVPVF RWYKFIEGTT RKQAVVLNDR 300
  301 VKQVSGTLII KDAVVEDSGK YLCVVNNSVG GESVETVLTV TAPLSAKIDP PTQTVDFGRP 360
  361 AVFTCQYTGN PIKTVSWMKD GKAIGHSEPV LRIESVKKED KGMYQCFVRN DQESAEASAE 420
  421 LKLGGRFDPP VIRQAFQEET MEPGPSVFLK CVAGGNPTPE ISWELDGKKI ANNDRYQVGQ 480
  481 YVTVNGDVVS YLNITSVHAN DGGLYKCIAK SKVGVAEHSA KLNVYGLPYI RQMEKKAIVA 540
  541 GETLIVTCPV AGYPIDSIVW ERDNRALPIN RKQKVFPNGT LIIENVERNS DQATYTCVAK 600
  601 NQEGYSARGS LEVQVMAPPK ITPFSFGEEP ANVEDSVSVT CLISTGDLPI DIEWFFNEYG 660
  661 ISSYSGISVM KGGKRNSVLS IDSVQARHAG NYSCRAKNHA AAVNYTTDLI VNVPPRWILE 720
  721 PTDKAFAQGS DAKVECKADG FPKPQVTWKK AVGDTPGEYK DLKKSDNIRV EEGTLHVDNI 780
  781 QKTNEGYYLC EAINGIGSGL SAVIMISVQA PPEFTEKLRN QTARRGEPAV LQCEAKGEKP 840
  841 IGILWNMNNM RLDPKNDNRY TIREEILSTG VMSSLSIKRT ERSDSALFTC VATNAFGSDD 900
  901 ASINMIVQEV PEMPYALKVL DKSGRSVQLS WAQPYDGNSP LDRYIIEFKR SRASWSEIDR 960
  961 VIVPGHTTEA QVQKLSPATT YNIRIVAENA IGTSQSSEAV TIITAEEAPS GKPQNIKVEP1020
 1021 VNQTTMRVTW KPPPRTEWNG EILGYYVGYK LSNTNSSYVF ETINFITEEG KEHNLELQNL1080
 1081 RVYTQYSVVI QAFNKIGAGP LSEEEKQFTA EGTPSQPPSD TACTTLTSQT IRVGWVSPPL1140
 1141 ESANGVIKTY KVVYAPSDEW YDETKRHYKK TASSDTVLHG LKKYTNYTMQ VLATTAGGDG1200
 1201 VRSVPIHCQT EPDVPEAPTD VKALVMGNAA ILVSWRPPAQ PNGIITQYTV YSKAEGAETE1260
 1261 TKTQKVPHYQ MSFEATELEK NKPYEFWVTA STTIGEGQQS KSIVAMPSDQ VPAKIASFDD1320
 1321 TFTATFKEDA KMPCLAVGAP QPEITWKIKG VEFSANDRMR VLPDGSLLIK SVNRQDAGDY1380
 1381 SCHAENSIAK DSITHKLIVL APPQSPHVTL SATTTDALTV KLKPHEGDTA PLHGYTLHYK1440
 1441 PEFGEWETSE VSVDSQKHNI EGLLCGSRYQ VYATGFNNIG AGEASDILNT RTKGQKPKLP1500
 1501 EKPRFIEVSS NSVSLHFKAW KDGGCPMSHF VVESKKRDQI EWNQISNNVK PDNNYVVLDL1560
 1561 EPATWYNLRI TAHNSAGFTV AEYDFATLTV TGGTIAPSRD LPELSAEDTI RIILSNLNLV1620
 1621 VPVVAALLVI IIAIIVICIL RSKGNHHKDD VVYNQTMGPG ATLDKRRPDL RDELGYIAPP1680
 1681 NRKLPPVPGS NYNTCDRIKR GRGGLRSNHS TWDPRRNPNL YEELKAPPVP MHGNHYGHAH1740
 1741 GNAECHYRHP GMEDEICPYA TFHLLGFREE MDPTKAMNFQ TFPHQNGHAG PVPGHAGTML1800
 1801 PPGHPGHVHS RSGSQSMPRA NRYQRKNSQG GQSSIYTPAP EYDDPANCAE EDQYRRYTRV1860
 1861 NSQGGSLYSG PGPEYDDPAN CAPEEDQYGS QYGGPYGQPY DHYGSRGSMG RRSIGSARNP1920
 1921 GNGSPEPPPP PPRNHDMSNS SFNDSKESNE ISEAECDRDH GPRGNYGAVK RSPQPKDQRT1980
 1981 TEEMRKLIER NETGPKQLQL QQANGAGFTA YDTMAV

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
telethonin binding	6.64811984458494	bayes_pls_golite062009
alpha-actinin binding	5.77350124471385	bayes_pls_golite062009
actinin binding	5.69539760434923	bayes_pls_golite062009
structural constituent of muscle	4.93896503565413	bayes_pls_golite062009
olfactory receptor activity	4.21057154107121	bayes_pls_golite062009
antigen binding	4.06466268219034	bayes_pls_golite062009
receptor activity	4.00123250685257	bayes_pls_golite062009
transmembrane receptor activity	3.81769911097805	bayes_pls_golite062009
binding	3.17641566810715	bayes_pls_golite062009
signal transducer activity	3.10913345555941	bayes_pls_golite062009
molecular transducer activity	3.10913345555941	bayes_pls_golite062009
peptide antigen binding	2.94721224577771	bayes_pls_golite062009
fibroblast growth factor 1 binding	2.83860944503193	bayes_pls_golite062009
growth factor binding	2.28613301180608	bayes_pls_golite062009
protein binding	2.22855404705168	bayes_pls_golite062009
extracellular matrix structural constituent	1.97667893885412	bayes_pls_golite062009
IgG binding	1.92633562075074	bayes_pls_golite062009
receptor binding	1.70260377709721	bayes_pls_golite062009
cytoskeletal protein binding	1.58610597245454	bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity	1.52958974617075	bayes_pls_golite062009
actin binding	1.42681407553255	bayes_pls_golite062009
cell adhesion molecule binding	1.36789541796983	bayes_pls_golite062009
protein kinase activity	1.36635494500222	bayes_pls_golite062009
nucleic acid binding	1.32330470851159	bayes_pls_golite062009
transmembrane receptor protein kinase activity	1.30657787244536	bayes_pls_golite062009
fibroblast growth factor binding	1.27793818082552	bayes_pls_golite062009
fibroblast growth factor receptor activity	1.24730237107473	bayes_pls_golite062009
DNA binding	1.19412627500732	bayes_pls_golite062009
myosin light chain kinase activity	1.17845072849922	bayes_pls_golite062009
transcription regulator activity	1.16252234499274	bayes_pls_golite062009
G-protein coupled receptor activity	1.02428106476324	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.02286631988334	bayes_pls_golite062009
kinase activity	0.929878054374821	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.878595022643164	bayes_pls_golite062009
protein complex binding	0.83543827718565	bayes_pls_golite062009
actin filament binding	0.760856470721016	bayes_pls_golite062009
peptide binding	0.729048089532569	bayes_pls_golite062009
collagen binding	0.635057461053063	bayes_pls_golite062009
cytokine binding	0.631436442105379	bayes_pls_golite062009
titin binding	0.599892148302011	bayes_pls_golite062009
integrin binding	0.599569390248921	bayes_pls_golite062009
structural molecule activity	0.567620977360967	bayes_pls_golite062009
protein serine/threonine kinase activity	0.564762108830441	bayes_pls_golite062009
transcription factor activity	0.54549168007511	bayes_pls_golite062009
myosin heavy chain binding	0.49788128784685	bayes_pls_golite062009
cytokine receptor activity	0.34165331857492	bayes_pls_golite062009
protein tyrosine kinase activity	0.318890055375093	bayes_pls_golite062009
structural constituent of cytoskeleton	0.0579247757286607	bayes_pls_golite062009

No functions predicted.

Source: Reynolds et al. 2008. Manuscript submitted

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..138]	PSI-BLAST	82.221849	No description for 2v5sA was found.
2	View Details	[139..247]	PSI-BLAST	10.154902	Immunoglobulin heavy chain variable domain, VH; Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma; Immunoglobulin heavy chain gamma constant domain 2, CH2-gamma; Immunoglobulin heavy chain gamma constant domain 3, CH3-gamma
3	View Details	[248..895]	PSI-BLAST	59.0	Model of human carcinoembryonic antigen by homology modelling and curve-fitting to experimental solution scattering data
4	View Details	[896..996]	PSI-BLAST	34.69897	No description for 2nziA was found.
5	View Details	[997..1103]	PSI-BLAST	11.0	No description for 2edxA was found.
6	View Details	[1104..1213]	PSI-BLAST	20.221849	Integin beta-4 subunit
7	View Details	[1214..1728]	PSI-BLAST	26.045757	No description for 2v5yA was found.
8	View Details	[1729..1903]	deduced	N/A	No confident structure predictions are available.
9	View Details	[1904..2016]	deduced	N/A	No confident structure predictions are available.

Protein Overview: Dscam-PV

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: