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View Structure Prediction Details

Protein: Dscam-PV
Organism: Drosophila melanogaster
Length: 2016 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Dscam-PV.

Description E-value Query
Range		 Subject
Range
Dscam-PR - The gene Down syndrome cell adhesion molecule is referred to in FlyBase by the symbol Dmel\Dscam (CG...
 1583.0 [0..3] [2016..3]

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Predicted Domain #1
Region A:
Residues: [1-138] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNMPNERLKW LMLFAAVALI ACGSQTLAAN PPDADQKGPV FLKEPTNRID FSNSTGAEIE  60
   61 CKASGNPMPE IIWIRSDGTA VGDVPGLRQI SSDGKLVFPP FRAEDYRQEV HAQVYACLAR 120
  121 NQFGSIISRD VHVRAVVA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 82.221849
Match: 2v5sA
Description: No description for 2v5sA was found.

Predicted Domain #2
Region A:
Residues: [139-247] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QYYDTDVNKA YVIRGNAAVL KCEIPSFVAD FVSVVSWHTD QNEDFLPGSE YDGKYLVLPS  60
   61 GELHIREVGP EDGYKSYQCR TKHRLTGETR LSATKGRLVI TEPIGSKAP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.154902
Match: 1igtB
Description: Immunoglobulin heavy chain variable domain, VH; Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma; Immunoglobulin heavy chain gamma constant domain 2, CH2-gamma; Immunoglobulin heavy chain gamma constant domain 3, CH3-gamma
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
telethonin binding 6.64811984458494 bayes_pls_golite062009
alpha-actinin binding 5.77350124471385 bayes_pls_golite062009
actinin binding 5.69539760434923 bayes_pls_golite062009
structural constituent of muscle 4.93896503565413 bayes_pls_golite062009
olfactory receptor activity 4.21057154107121 bayes_pls_golite062009
antigen binding 4.06466268219034 bayes_pls_golite062009
receptor activity 4.00123250685257 bayes_pls_golite062009
transmembrane receptor activity 3.81769911097805 bayes_pls_golite062009
binding 3.17641566810715 bayes_pls_golite062009
signal transducer activity 3.10913345555941 bayes_pls_golite062009
molecular transducer activity 3.10913345555941 bayes_pls_golite062009
peptide antigen binding 2.94721224577771 bayes_pls_golite062009
fibroblast growth factor 1 binding 2.83860944503193 bayes_pls_golite062009
growth factor binding 2.28613301180608 bayes_pls_golite062009
protein binding 2.22855404705168 bayes_pls_golite062009
extracellular matrix structural constituent 1.97667893885412 bayes_pls_golite062009
IgG binding 1.92633562075074 bayes_pls_golite062009
receptor binding 1.70260377709721 bayes_pls_golite062009
cytoskeletal protein binding 1.58610597245454 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 1.52958974617075 bayes_pls_golite062009
actin binding 1.42681407553255 bayes_pls_golite062009
cell adhesion molecule binding 1.36789541796983 bayes_pls_golite062009
protein kinase activity 1.36635494500222 bayes_pls_golite062009
nucleic acid binding 1.32330470851159 bayes_pls_golite062009
transmembrane receptor protein kinase activity 1.30657787244536 bayes_pls_golite062009
fibroblast growth factor binding 1.27793818082552 bayes_pls_golite062009
fibroblast growth factor receptor activity 1.24730237107473 bayes_pls_golite062009
DNA binding 1.19412627500732 bayes_pls_golite062009
myosin light chain kinase activity 1.17845072849922 bayes_pls_golite062009
transcription regulator activity 1.16252234499274 bayes_pls_golite062009
G-protein coupled receptor activity 1.02428106476324 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.02286631988334 bayes_pls_golite062009
kinase activity 0.929878054374821 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.878595022643164 bayes_pls_golite062009
protein complex binding 0.83543827718565 bayes_pls_golite062009
actin filament binding 0.760856470721016 bayes_pls_golite062009
peptide binding 0.729048089532569 bayes_pls_golite062009
collagen binding 0.635057461053063 bayes_pls_golite062009
cytokine binding 0.631436442105379 bayes_pls_golite062009
titin binding 0.599892148302011 bayes_pls_golite062009
integrin binding 0.599569390248921 bayes_pls_golite062009
structural molecule activity 0.567620977360967 bayes_pls_golite062009
protein serine/threonine kinase activity 0.564762108830441 bayes_pls_golite062009
transcription factor activity 0.54549168007511 bayes_pls_golite062009
myosin heavy chain binding 0.49788128784685 bayes_pls_golite062009
cytokine receptor activity 0.34165331857492 bayes_pls_golite062009
protein tyrosine kinase activity 0.318890055375093 bayes_pls_golite062009
structural constituent of cytoskeleton 0.0579247757286607 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [248-895] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SVPTGVMVFQ QQVPLLSTFA MLCQAQAFPV PVFRWYKFIE GTTRKQAVVL NDRVKQVSGT  60
   61 LIIKDAVVED SGKYLCVVNN SVGGESVETV LTVTAPLSAK IDPPTQTVDF GRPAVFTCQY 120
  121 TGNPIKTVSW MKDGKAIGHS EPVLRIESVK KEDKGMYQCF VRNDQESAEA SAELKLGGRF 180
  181 DPPVIRQAFQ EETMEPGPSV FLKCVAGGNP TPEISWELDG KKIANNDRYQ VGQYVTVNGD 240
  241 VVSYLNITSV HANDGGLYKC IAKSKVGVAE HSAKLNVYGL PYIRQMEKKA IVAGETLIVT 300
  301 CPVAGYPIDS IVWERDNRAL PINRKQKVFP NGTLIIENVE RNSDQATYTC VAKNQEGYSA 360
  361 RGSLEVQVMA PPKITPFSFG EEPANVEDSV SVTCLISTGD LPIDIEWFFN EYGISSYSGI 420
  421 SVMKGGKRNS VLSIDSVQAR HAGNYSCRAK NHAAAVNYTT DLIVNVPPRW ILEPTDKAFA 480
  481 QGSDAKVECK ADGFPKPQVT WKKAVGDTPG EYKDLKKSDN IRVEEGTLHV DNIQKTNEGY 540
  541 YLCEAINGIG SGLSAVIMIS VQAPPEFTEK LRNQTARRGE PAVLQCEAKG EKPIGILWNM 600
  601 NNMRLDPKND NRYTIREEIL STGVMSSLSI KRTERSDSAL FTCVATNA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 59.0
Match: 1e07A
Description: Model of human carcinoembryonic antigen by homology modelling and curve-fitting to experimental solution scattering data
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [896-996] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FGSDDASINM IVQEVPEMPY ALKVLDKSGR SVQLSWAQPY DGNSPLDRYI IEFKRSRASW  60
   61 SEIDRVIVPG HTTEAQVQKL SPATTYNIRI VAENAIGTSQ S

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 34.69897
Match: 2nziA
Description: No description for 2nziA was found.

Predicted Domain #5
Region A:
Residues: [997-1103] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SEAVTIITAE EAPSGKPQNI KVEPVNQTTM RVTWKPPPRT EWNGEILGYY VGYKLSNTNS  60
   61 SYVFETINFI TEEGKEHNLE LQNLRVYTQY SVVIQAFNKI GAGPLSE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.0
Match: 2edxA
Description: No description for 2edxA was found.

Predicted Domain #6
Region A:
Residues: [1104-1213] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EEKQFTAEGT PSQPPSDTAC TTLTSQTIRV GWVSPPLESA NGVIKTYKVV YAPSDEWYDE  60
   61 TKRHYKKTAS SDTVLHGLKK YTNYTMQVLA TTAGGDGVRS VPIHCQTEPD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 20.221849
Match: 1qg3A
Description: Integin beta-4 subunit
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [1214-1728] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VPEAPTDVKA LVMGNAAILV SWRPPAQPNG IITQYTVYSK AEGAETETKT QKVPHYQMSF  60
   61 EATELEKNKP YEFWVTASTT IGEGQQSKSI VAMPSDQVPA KIASFDDTFT ATFKEDAKMP 120
  121 CLAVGAPQPE ITWKIKGVEF SANDRMRVLP DGSLLIKSVN RQDAGDYSCH AENSIAKDSI 180
  181 THKLIVLAPP QSPHVTLSAT TTDALTVKLK PHEGDTAPLH GYTLHYKPEF GEWETSEVSV 240
  241 DSQKHNIEGL LCGSRYQVYA TGFNNIGAGE ASDILNTRTK GQKPKLPEKP RFIEVSSNSV 300
  301 SLHFKAWKDG GCPMSHFVVE SKKRDQIEWN QISNNVKPDN NYVVLDLEPA TWYNLRITAH 360
  361 NSAGFTVAEY DFATLTVTGG TIAPSRDLPE LSAEDTIRII LSNLNLVVPV VAALLVIIIA 420
  421 IIVICILRSK GNHHKDDVVY NQTMGPGATL DKRRPDLRDE LGYIAPPNRK LPPVPGSNYN 480
  481 TCDRIKRGRG GLRSNHSTWD PRRNPNLYEE LKAPP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 26.045757
Match: 2v5yA
Description: No description for 2v5yA was found.

Predicted Domain #8
Region A:
Residues: [1729-1903] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VPMHGNHYGH AHGNAECHYR HPGMEDEICP YATFHLLGFR EEMDPTKAMN FQTFPHQNGH  60
   61 AGPVPGHAGT MLPPGHPGHV HSRSGSQSMP RANRYQRKNS QGGQSSIYTP APEYDDPANC 120
  121 AEEDQYRRYT RVNSQGGSLY SGPGPEYDDP ANCAPEEDQY GSQYGGPYGQ PYDHY

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #9
Region A:
Residues: [1904-2016] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSRGSMGRRS IGSARNPGNG SPEPPPPPPR NHDMSNSSFN DSKESNEISE AECDRDHGPR  60
   61 GNYGAVKRSP QPKDQRTTEE MRKLIERNET GPKQLQLQQA NGAGFTAYDT MAV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle