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Protein Overview: NAT3

General Information:
Name(s) found: NAT3 / YPR131C [SGD]
Description(s) found:
Found 18 descriptions.
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  • Catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 195 amino acids

    Gene Ontology:
    Cellular Component: NatB complex [TASLink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: mitochondrion inheritance [IGILink to PubMed article][IMPLink to PubMed article]
    cytoskeleton organization [IGILink to PubMed article][IMPLink to PubMed article]
    N-terminal peptidyl-methionine acetylation [IMPLink to PubMed article]
    telomere maintenance [IMPLink to PubMed article]
    Molecular Function: peptide alpha-N-acetyltransferase activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTIQPFEPV DLFKTNNVNL DILTENFPLE FYFEYMIIWP DLFFKSSEMT VDPTFKHNIS  60
   61 GYMMAKTEGK TTEWHTHITA VTVAPRFRRI SLASKLCNTL ETMTDVMPHE VNFIDLFVKC 120
  121 NNQLAIKLYE KLGYSVYRRV VGYYNSAEDG YPDTLKKVDD NKDAFDMRKA MARDRNRSVR 180
  181 PDGRSHKCYP HDVRF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) MDM20 NAT3
    View Details Krogan NJ, et al. (2006) MDM20 NAT3
    View Details Qiu et al. (2008) ARD1 ASC1 ATG27 HMS2 MAK10 MAK3 MAK31 MDM20 NAT1 NAT3 NAT5 PUF2 RKI1 RPL10 RPL11A RPL11B RPL12B, RPL12A RPL13A RPL13B RPL14A RPL15A RPL16A RPL16B RPL17A RPL17B RPL18A, RPL18B RPL19B, RPL19A RPL1A, RPL1B RPL20A RPL20B RPL21A RPL21B RPL22A RPL22B RPL23B, RPL23A RPL24A RPL24B RPL26A RPL26B RPL27B RPL28 RPL29 RPL2A, RPL2B RPL30 RPL31A RPL31B RPL33A RPL33B RPL34A RPL35A, RPL35B RPL36A RPL36B RPL37A RPL37B RPL38 RPL39 RPL40B, RPL40A RPL41A, RPL41B RPL42B, RPL42A RPL43B, RPL43A RPL5 RPL6A RPL6B RPL8A RPL9A RPL9B RPP0 RPP1B RPP2A RPS0A RPS0B RPS10A RPS10B RPS11A, RPS11B RPS12 RPS13 RPS14B RPS15 RPS16B, RPS16A RPS17A RPS17B RPS18B, RPS18A RPS19A RPS19B RPS1A RPS1B RPS2 RPS20 RPS21B RPS23B, RPS23A RPS24A, RPS24B RPS25A RPS25B RPS26A RPS26B RPS27A RPS27B RPS29A RPS29B RPS30B, RPS30A RPS31 RPS4B, RPS4A RPS6A, RPS6B RPS7A RPS7B RPS8B, RPS8A RPS9B SOP4 YPL199C

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data NAT3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..195] PSI-BLAST 15.0 Crystal structure of a putative phosphinothricin N-acetyltransferase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • N-acetyltransferase activity
    		•  6.09290029352595 bayes_pls_golite062009
  • N-acyltransferase activity
    		•  6.08913516066746 bayes_pls_golite062009
  • acetyltransferase activity
    		•  5.86411968036951 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  5.85159161781386 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  5.85159161781386 bayes_pls_golite062009
  • acyltransferase activity
    		•  4.72881921515185 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  4.70793039001114 bayes_pls_golite062009
  • transferase activity, transferring acyl groups other than amino-acyl groups
    		•  4.69837915971204 bayes_pls_golite062009
  • transferase activity
    		•  3.5778020729894 bayes_pls_golite062009
  • myristoyltransferase activity
    		•  3.50779447340192 bayes_pls_golite062009
  • glycylpeptide N-tetradecanoyltransferase activity
    		•  3.50779447340192 bayes_pls_golite062009
    		• 3.29707445389818 bayes_pls_golite062009
  • catalytic activity
    		•  1.97933499002461 bayes_pls_golite062009
  • binding
    		•  1.07749536895426 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.522132859536345 bayes_pls_golite062009
  • protein binding
    		•  0.098756769132141 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.0766125702622449 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle