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Protein Overview: GCV3

General Information:
Name(s) found: GCV3 / YAL044C [SGD]
Description(s) found:
Found 14 descriptions.
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  • H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 170 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article][TAS]
    glycine cleavage complex [TASLink to PubMed article]
    Biological Process: telomere maintenance [IMPLink to PubMed article]
    glycine catabolic process [ICLink to PubMed article]
    one-carbon metabolic process [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: glycine dehydrogenase (decarboxylating) activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRTTRLWTT RMPAVSKLFL RNSSGNALNK NKLPFLYSSQ GPQAVRYTSQ HEWIAVHQDK  60
   61 TAFVGITKYA TDSLGDATYV ELPEVGTEIS QGESLGSIES VKSASEIYQP ADGTVEEINT 120
  121 NLEENPGVVN EDPMGDGWLV KMKLGEGVNV EQVEGLMSLE QYEKTLVHDD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) GCV1 GCV2 GCV3 LPD1
    View Details Krogan NJ, et al. (2006) GCV3 LIP2
    View Details Qiu et al. (2008) GCV3 LPD1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen NPA3 GCV3 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data GCV3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..170] PSI-BLAST 34.39794 Protein H of glycine cleavage system


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.80

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle