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Protein Overview: GCV1

General Information:
Name(s) found: GCV1 / YDR019C [SGD]
Description(s) found:
Found 32 descriptions.
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  • T subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 400 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article][TASLink to PubMed article]
    glycine cleavage complex [TASLink to PubMed article]
    Biological Process: glycine catabolic process [ICLink to PubMed article]
    one-carbon metabolic process [IGILink to PubMed article][IMPLink to PubMed article]
    glycine metabolic process [IMPLink to PubMed article]
    Molecular Function: glycine dehydrogenase (decarboxylating) activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSIIKKIVFK RFNSTLKKTA LHDLHVSLGG TMVPYAGYSM PVLYKGQTHI ESHNWTRTNA  60
   61 GLFDVSHMLQ SKLSGPHSVK FLQRVTPTDF NALPVGSGTL SVLLNPQGGV VDDTIITKEN 120
  121 DDNEFYIVTN AGCAERDTEF FHDELQNGST LDCQWKIIEG RSLLALQGPK AKDVLEPLLS 180
  181 KTAPGKDLKE LFFGQRHEFA LKDGSLVQIA RGGYTGEDGF EISIANEKAV EFAEQLLANP 240
  241 VMKPIGLAAR DSLRLEAGMC LYGHELDESI TPVEAALNWV ISKSRRDLVD QKYWFNGYAK 300
  301 IMDQLNNKTY SKVRVGFKYL KKGPAARNGV KIFLPDAETE VGLVTSGSAS PTLNNINIGQ 360
  361 AYVQKGYHKK GTKLLVQVRN KFYPIELAKM PLVPTHYYKQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) GCV1 GCV2 GCV3 LPD1
    View Details Qiu et al. (2008) GCV1 LPD1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data GCV1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..400] Pfam 186.19382 Glycine cleavage T-protein (aminomethyl transferase) No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.56

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle