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Protein Overview: MEX67

General Information:
Name(s) found: MEX67 / YPL169C [SGD]
Description(s) found:
Found 24 descriptions.
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  • Poly(A)RNA binding protein involved in nuclear mRNA export, component of the nuclear pore; ortholog of human TAP [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 599 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    nuclear pore [IDALink to PubMed article]
    Biological Process: mRNA export from nucleus [IMPLink to PubMed article]
    Molecular Function: RNA binding [IDALink to PubMed article]
    protein binding [IPILink to PubMed article]
    structural constituent of nuclear pore [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGFHNVGNI NMMAQQQMQQ NRIKISVRNW QNATMNDLIN FISRNARVAV YDAHVEGPLV  60
   61 IGYVNSKAEA ESLMKWNGVR FAGSNLKFEL LDNNGASAGT SDTISFLRGV LLKRYDPQTK 120
  121 LLNLGALHSD PELIQKGVFS SISTQSKMFP AMMKLASTEK SLIVESVNLA DNQLKDISAI 180
  181 STLAQTFPNL KNLCLANNQI FRFRSLEVWK NKFKDLRELL MTNNPITTDK LYRTEMLRLF 240
  241 PKLVVLDNVI VRDEQKLQTV YSLPMKIQQF FFENDALGQS STDFATNFLN LWDNNREQLL 300
  301 NLYSPQSQFS VSVDSTIPPS TVTDSDQTPA FGYYMSSSRN ISKVSSEKSI QQRLSIGQES 360
  361 INSIFKTLPK TKHHLQEQPN EYSMETISYP QINGFVITLH GFFEETGKPE LESNKKTGKN 420
  421 NYQKNRRYNH GYNSTSNNKL SKKSFDRTWV IVPMNNSVII ASDLLTVRAY STGAWKTASI 480
  481 AIAQPPQQQA SVLPQVASMN PNITTPPQPQ PSVVPGGMSI PGAPQGAMVM APTLQLPPDV 540
  541 QSRLNPVQLE LLNKLHLETK LNAEYTFMLA EQSNWNYEVA IKGFQSSMNG IPREAFVQF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) MEX67 NUP120 NUP145 NUP84 NUP85 SEH1
    View Details Qiu et al. (2008) ASM4 KAP120 MEX67 NDC1 NIC96 NUP1 NUP100 NUP116 NUP145 NUP157 NUP188 NUP2 NUP57 NUP60 NUP82 NUP84 POM152 SEH1 SUS1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data MEX67 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..98] PSI-BLAST 118.927757 mRNA export factor tap
    2 View Details [99..260] PSI-BLAST 118.927757 mRNA export factor tap
    3 View Details [261..375] PSI-BLAST 21.221849 Reticulon 4 receptor (Nogo-66 receptor, Ngr)
    4 View Details [376..445] deduced N/A No confident structure predictions are available.
    5 View Details [446..599] PSI-BLAST 39.69897 NTF2-like domain of Tip associating protein, TAP

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • receptor activity
    		•  2.45747497442245 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.20259885800343 bayes_pls_golite062009
  • signal transducer activity
    		•  2.14481842394036 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.14481842394036 bayes_pls_golite062009
  • binding
    		•  1.87302803330255 bayes_pls_golite062009
  • structural molecule activity
    		•  1.83189461928225 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.5811568573961 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  1.43652168420174 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.2741906444944 bayes_pls_golite062009
  • actin binding
    		•  0.666110887282576 bayes_pls_golite062009
  • protein binding
    		•  0.646159692466759 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • nucleocytoplasmic transporter activity
    		•  4.11811310168752 bayes_pls_golite062009
  • protein transporter activity
    		•  3.25560675565407 bayes_pls_golite062009
  • binding
    		•  2.52411158739487 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  2.19585939185279 bayes_pls_golite062009
  • structural constituent of nuclear pore
    		•  2.18859566641856 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.1539951593359 bayes_pls_golite062009
  • transporter activity
    		•  1.80701285041353 bayes_pls_golite062009
  • structural molecule activity
    		•  1.60851232976006 bayes_pls_golite062009
  • mRNA binding
    		•  1.48678274024408 bayes_pls_golite062009
  • protein binding
    		•  1.34243535208605 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.33804818542017 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.22102896992563 bayes_pls_golite062009
  • Ran GTPase binding
    		•  1.18290069522408 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.890150150408175 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven protein transmembrane transporter activity
    		•  0.77053580490303 bayes_pls_golite062009
  • macromolecule transmembrane transporter activity
    		•  0.77053580490303 bayes_pls_golite062009
  • RNA binding
    		•  0.47499792472996 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.446562877324676 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.439519001457896 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.430285640125175 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle