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Protein Overview: APC1

General Information:
Name(s) found: APC1 / YNL172W [SGD]
Description(s) found:
Found 18 descriptions.
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  • Largest subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1748 amino acids

    Gene Ontology:
    Cellular Component: anaphase-promoting complex [TASLink to PubMed article]
    Biological Process: mitotic spindle elongation [TASLink to PubMed article]
    cyclin catabolic process [TASLink to PubMed article]
    mitotic sister chromatid segregation [TASLink to PubMed article]
    anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [IDALink to PubMed article][IPILink to PubMed article]
    mitotic metaphase/anaphase transition [TASLink to PubMed article]
    protein ubiquitination [IPILink to PubMed article]
    Molecular Function: ubiquitin-protein ligase activity [TASLink to PubMed article]
    protein binding [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSKPSTRND YLPRETHNGE YTGDSPEWQL QINITNKIGG INGDIWLSRD GRSVKWCIED  60
   61 QCLRQFTYNQ KIIKAGYIDF EKTPDCFVVV LSDIAHVYML KNGGSTTVCF PFQIGNAFWY 120
  121 ANGVILERET SASFMDGGYD LKPIEFDLKH KYITLTDPMA PFGLISITNT FKGGINSASG 180
  181 NKTDILQDFQ LVLFPSDKDK CIAVFLDRNS KVLRFYYSRI LSSDQSRKGE LTISSTKKTG 240
  241 LDAAGNSQKS GGISKDLRKF SHLTRRSTSI NSNSHDFNAA ERVLSGNVGN ASGRTDIFAL 300
  301 PSSCSRRSLS ATLDRMGNNI APTNRAAPSG FFDSSSANTA THSNITPVSQ PMQQQQQEYL 360
  361 NQTATSSKDI VLTEISSLKL PDDIIFTSRR LSSILSKLKF LSLRFERREG LLIFHEPTHF 420
  421 CKIWLIDLLP DVLDSIPFKI YGNSPQNMIR LENLKLKEPS RIQAMYIHEL LESCLILVSE 480
  481 GQNKEEYKAC LYDPFVKITS PSKNISEELT KQNSLPSLQK LFPYPETSFT KLCFEAVKYI 540
  541 TSPAFNISFI FLWQSAYSIL LSRANDDVVG GLKMEHDAFS LVLSLLILPI PSSSAQEYQE 600
  601 YKEIYERDLF QHLKQDSEIT SSVLPRIVIG LHLIREEYSL NVLCRNEHAL LGQFLRFATA 660
  661 AMGWPDLWQS YYVPKMDSES KTFLHPREQN STFFHPLDEP PSITKSLYSI TENSSIPLCP 720
  721 FISFSRLVAT DTQVELRITP RSFKILGLYE LVHSPNFLPD YVLGILSSFK VDKDELQTYP 780
  781 LGILVPLQNI LKILEDKLSE VRDNLELLDR ADLQRCSAII NSIRSDSKEV LKRGQRDSYM 840
  841 LCKVPLAKNR SSLSKKPSDI YSILSEIVKS ASQVPLDGSA MRMSNIQDDE DIDEGRSLKL 900
  901 NAGLIFSEDK RFTHVVSLLA YYRPTKTQFF TTKTEYAQIL AQKKYFAKIM ALRTCTNGVG 960
  961 WGAVAYATEK PISTQKWVIQ PLNLISVFPD DTKITVKAPE DIAHDIVEWG QFHAGVSSGL1020
 1021 RISKKATGIT GSWIAFNKPK ELDAYHGGFL LGLGLNGHLK NLEEWHIYNY LSPRNTHISI1080
 1081 GLLLGMSSSM KGSMDSKLIK VISVHLVAFL PSGSSDLNID LKLQTAGIIG MGMLYLNSRH1140
 1141 KRMSDSIFAQ LVSLLNVNDE MVADEEYRLA AGISLGLINL GAGQTKLRKW DSSLLGLGDD1200
 1201 LPEDVYDSSD VEQNVMYEDL TTKLLEIVTS TYDVENDWIP ENSQIGAVIA IMFLFLKSNN1260
 1261 FGISNMLKVD LKEILKANIN TRPELLMYRE WASNMILWEF IGDDLSFIMK DVDIGVKFSE1320
 1321 LNTDLLPIYY TMAGRILAMG IRFASTGNLK IRNILLSLVD KFLPLYQYPG KQNLDFRLTI1380
 1381 SVINVLTNVI VVSLSMVMCA SGDLEVLRRV KYLHEVASGP YSDLFQEIPS SKSDVSGVTQ1440
 1441 VTSNTNTPGN SDRERVDETA ASLDDERSSN GSDISDPTAY LEDKKDIDDH YGKFISTNLA1500
 1501 LGFLFLGSGQ YALNTSTLES IAFLSMSVLP TYTTPHPLQE LKHFWSIAVE PRCLVIKDIS1560
 1561 TGDAVNNVPI ELVVEEDVEK EEVIREISTP CLLPDFSKIK SIRVKMHGYF PLEVNFTKDY1620
 1621 SASDFFSGGT IIYIQRKSES VFENKASFRN VEDIHVALKR KAAESKNYSR LNLKNEQGNT1680
 1681 TSSQLVESLG IQDLTMVELD TLLSAGNNTA LTDSESYNLG LLCSDKNSGD ILDCQLELWY1740
 1741 KSFGPHDE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) APC1 APC2 APC4 APC5 CDC16 CDC23 CDC27
    View Details (MIPS) Mewes HW, et al. (2004) APC1 APC11 APC2 APC4 APC5 APC9 CDC16 CDC23 CDC26 CDC27 DOC1
    View Details Krogan NJ, et al. (2006) APC1 APC2 APC4 APC5 CDC16 CDC23 CDC26 CDC27 DOC1 FMP52 MND2 SSP2
    View Details Gavin AC, et al. (2006) APC1 APC2 APC4 APC5 APC9 CDC16 CDC23 CDC27
    View Details Gavin AC, et al. (2002) ACT1 APC1 APC2 CDC16 CDC23 CDC27
    View Details Ho Y, et al. (2002) APC1 TMA29 YCK1
    View Details Qiu et al. (2008) APC1 APC11 APC2 APC4 APC5 APC9 BUL2 CDC16 CDC23 CDC26 CDC27 DOC1 HRT1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run ASF1 3829 - low filter Green EM, et al (2005)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen EUG1 APC1 1 Unpublished Fields Lab Data
    View Screen LOS1 APC1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data APC1 and SPC42 Huh WK, et al. (2003)
    View Data APC1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..591] deduced N/A No confident structure predictions are available.
    2 View Details [592..1445] MSA 5.009001 View MSA. No confident structure predictions are available.
    3 View Details [1446..1562] deduced N/A No confident structure predictions are available.
    4 View Details [1563..1645] MSA 1.003977 View MSA. No confident structure predictions are available.
    5 View Details [1646..1748] deduced N/A No confident structure predictions are available.
    6 View Details [885..970] deduced N/A No confident structure predictions are available.
    7 View Details [971..1025] MSA 1.042991 View MSA. No confident structure predictions are available.
    8 View Details [1026..1748] FFAS03 0.951 No description for 2ie3A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8
    Term Confidence Notes
  • binding
    		•  2.81296846555705 bayes_pls_golite062009
  • protein binding
    		•  1.81870125631028 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.08079130332447 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.73539719922204 bayes_pls_golite062009
  • hydrolase activity
    		•  0.46329207154863 bayes_pls_golite062009
  • protein kinase activity
    		•  0.317596068919701 bayes_pls_golite062009
  • DNA binding
    		•  0.180353635969032 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.0926408709390653 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.0196841005896076 bayes_pls_golite062009
  • actin binding
    		•  0.00917667862812865 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.63

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle