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View Structure Prediction Details

Protein: APC1
Organism: Saccharomyces cerevisiae
Length: 1748 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for APC1.

Description E-value Query
Range
Subject
Range
APC1 - Largest subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein li...
0.0 [1..1748] [1..1748]
gi|168278363 - gi|168278363|dbj|BAG11061.1| anaphase-promoting complex subunit 1 [synthetic construct]
ANAPC1 - anaphase promoting complex subunit 1
0.0 [600..1419] [734..1548]
APC1_MOUSE, ANC1... - Anaphase-promoting complex subunit 1 OS=Mus musculus GN=Anapc1 PE=1 SV=1, Anaphase-promoting complex...
0.0 [600..1419] [734..1548]
gi|25460280, gi|... - pir||T51995 hypothetical protein cut4+ - fission yeast (Schizosaccharomyces pombe), gi|2506062|dbj...
0.0 [593..1419] [434..1183]
APC1_SCHPO - Anaphase-promoting complex subunit 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=cut4 ...
cut4 - anaphase-promoting complex subunit Apc1
0.0 [593..1419] [434..1183]
BIME_EMENI - Negative regulator of mitosis OS=Emericella nidulans GN=bimE PE=2 SV=1
0.0 [606..1421] [939..1719]
shtd-PA - The gene shattered is referred to in FlyBase by the symbol Dmel\shtd (CG9198, FBgn0004391). It is a ...
0.0 [619..1421] [817..1625]
APC1_ARATH - Anaphase-promoting complex subunit 1 OS=Arabidopsis thaliana GN=APC1 PE=2 SV=1
0.0 [631..1416] [586..1345]
CE21288 - WBGene00003133 locus:mat-2 status:Partially_confirmed TR:O18191 protein_id:CAB16467.1
0.0 [895..1423] [587..1180]

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Predicted Domain #1
Region A:
Residues: [1-591]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSKPSTRND YLPRETHNGE YTGDSPEWQL QINITNKIGG INGDIWLSRD GRSVKWCIED  60
   61 QCLRQFTYNQ KIIKAGYIDF EKTPDCFVVV LSDIAHVYML KNGGSTTVCF PFQIGNAFWY 120
  121 ANGVILERET SASFMDGGYD LKPIEFDLKH KYITLTDPMA PFGLISITNT FKGGINSASG 180
  181 NKTDILQDFQ LVLFPSDKDK CIAVFLDRNS KVLRFYYSRI LSSDQSRKGE LTISSTKKTG 240
  241 LDAAGNSQKS GGISKDLRKF SHLTRRSTSI NSNSHDFNAA ERVLSGNVGN ASGRTDIFAL 300
  301 PSSCSRRSLS ATLDRMGNNI APTNRAAPSG FFDSSSANTA THSNITPVSQ PMQQQQQEYL 360
  361 NQTATSSKDI VLTEISSLKL PDDIIFTSRR LSSILSKLKF LSLRFERREG LLIFHEPTHF 420
  421 CKIWLIDLLP DVLDSIPFKI YGNSPQNMIR LENLKLKEPS RIQAMYIHEL LESCLILVSE 480
  481 GQNKEEYKAC LYDPFVKITS PSKNISEELT KQNSLPSLQK LFPYPETSFT KLCFEAVKYI 540
  541 TSPAFNISFI FLWQSAYSIL LSRANDDVVG GLKMEHDAFS LVLSLLILPI P

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [592-1445]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSSAQEYQEY KEIYERDLFQ HLKQDSEITS SVLPRIVIGL HLIREEYSLN VLCRNEHALL  60
   61 GQFLRFATAA MGWPDLWQSY YVPKMDSESK TFLHPREQNS TFFHPLDEPP SITKSLYSIT 120
  121 ENSSIPLCPF ISFSRLVATD TQVELRITPR SFKILGLYEL VHSPNFLPDY VLGILSSFKV 180
  181 DKDELQTYPL GILVPLQNIL KILEDKLSEV RDNLELLDRA DLQRCSAIIN SIRSDSKEVL 240
  241 KRGQRDSYML CKVPLAKNRS SLSKKPSDIY SILSEIVKSA SQVPLDGSAM RMSNIQDDED 300
  301 IDEGRSLKLN AGLIFSEDKR FTHVVSLLAY YRPTKTQFFT TKTEYAQILA QKKYFAKIMA 360
  361 LRTCTNGVGW GAVAYATEKP ISTQKWVIQP LNLISVFPDD TKITVKAPED IAHDIVEWGQ 420
  421 FHAGVSSGLR ISKKATGITG SWIAFNKPKE LDAYHGGFLL GLGLNGHLKN LEEWHIYNYL 480
  481 SPRNTHISIG LLLGMSSSMK GSMDSKLIKV ISVHLVAFLP SGSSDLNIDL KLQTAGIIGM 540
  541 GMLYLNSRHK RMSDSIFAQL VSLLNVNDEM VADEEYRLAA GISLGLINLG AGQTKLRKWD 600
  601 SSLLGLGDDL PEDVYDSSDV EQNVMYEDLT TKLLEIVTST YDVENDWIPE NSQIGAVIAI 660
  661 MFLFLKSNNF GISNMLKVDL KEILKANINT RPELLMYREW ASNMILWEFI GDDLSFIMKD 720
  721 VDIGVKFSEL NTDLLPIYYT MAGRILAMGI RFASTGNLKI RNILLSLVDK FLPLYQYPGK 780
  781 QNLDFRLTIS VINVLTNVIV VSLSMVMCAS GDLEVLRRVK YLHEVASGPY SDLFQEIPSS 840
  841 KSDVSGVTQV TSNT

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [1446-1562]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NTPGNSDRER VDETAASLDD ERSSNGSDIS DPTAYLEDKK DIDDHYGKFI STNLALGFLF  60
   61 LGSGQYALNT STLESIAFLS MSVLPTYTTP HPLQELKHFW SIAVEPRCLV IKDISTG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [1563-1645]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DAVNNVPIEL VVEEDVEKEE VIREISTPCL LPDFSKIKSI RVKMHGYFPL EVNFTKDYSA  60
   61 SDFFSGGTII YIQRKSESVF ENK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [1646-1748]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ASFRNVEDIH VALKRKAAES KNYSRLNLKN EQGNTTSSQL VESLGIQDLT MVELDTLLSA  60
   61 GNNTALTDSE SYNLGLLCSD KNSGDILDCQ LELWYKSFGP HDE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [885-970]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NIQDDEDIDE GRSLKLNAGL IFSEDKRFTH VVSLLAYYRP TKTQFFTTKT EYAQILAQKK  60
   61 YFAKIMALRT CTNGVGWGAV AYATEK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [971-1025]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PISTQKWVIQ PLNLISVFPD DTKITVKAPE DIAHDIVEWG QFHAGVSSGL RISKK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [1026-1748]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ATGITGSWIA FNKPKELDAY HGGFLLGLGL NGHLKNLEEW HIYNYLSPRN THISIGLLLG  60
   61 MSSSMKGSMD SKLIKVISVH LVAFLPSGSS DLNIDLKLQT AGIIGMGMLY LNSRHKRMSD 120
  121 SIFAQLVSLL NVNDEMVADE EYRLAAGISL GLINLGAGQT KLRKWDSSLL GLGDDLPEDV 180
  181 YDSSDVEQNV MYEDLTTKLL EIVTSTYDVE NDWIPENSQI GAVIAIMFLF LKSNNFGISN 240
  241 MLKVDLKEIL KANINTRPEL LMYREWASNM ILWEFIGDDL SFIMKDVDIG VKFSELNTDL 300
  301 LPIYYTMAGR ILAMGIRFAS TGNLKIRNIL LSLVDKFLPL YQYPGKQNLD FRLTISVINV 360
  361 LTNVIVVSLS MVMCASGDLE VLRRVKYLHE VASGPYSDLF QEIPSSKSDV SGVTQVTSNT 420
  421 NTPGNSDRER VDETAASLDD ERSSNGSDIS DPTAYLEDKK DIDDHYGKFI STNLALGFLF 480
  481 LGSGQYALNT STLESIAFLS MSVLPTYTTP HPLQELKHFW SIAVEPRCLV IKDISTGDAV 540
  541 NNVPIELVVE EDVEKEEVIR EISTPCLLPD FSKIKSIRVK MHGYFPLEVN FTKDYSASDF 600
  601 FSGGTIIYIQ RKSESVFENK ASFRNVEDIH VALKRKAAES KNYSRLNLKN EQGNTTSSQL 660
  661 VESLGIQDLT MVELDTLLSA GNNTALTDSE SYNLGLLCSD KNSGDILDCQ LELWYKSFGP 720
  721 HDE

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 0.951
Match: 2ie3A
Description: No description for 2ie3A was found.

Predicted functions:

Term Confidence Notes
binding 2.81296846555705 bayes_pls_golite062009
protein binding 1.81870125631028 bayes_pls_golite062009
nucleic acid binding 1.08079130332447 bayes_pls_golite062009
cytoskeletal protein binding 0.73539719922204 bayes_pls_golite062009
hydrolase activity 0.46329207154863 bayes_pls_golite062009
protein kinase activity 0.317596068919701 bayes_pls_golite062009
DNA binding 0.180353635969032 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.0926408709390653 bayes_pls_golite062009
transcription regulator activity 0.0196841005896076 bayes_pls_golite062009
actin binding 0.00917667862812865 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle