Protein Overview: HBS1

General Information:
Name(s) found:	HBS1 / YKR084C [SGD]
Description(s) found: Found 25 descriptions. SHOW ALL	GTP binding protein with sequence similarity to the elongation factor class of G proteins, EF-1alpha and Sup35p; associates with Dom34p, and shares a similar genetic relationship with genes that encode ribosomal protein components [SGD]
Organism:	Saccharomyces cerevisiae
Length:	611 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IDA]
Biological Process:	translation [IMP][IPI]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAYSDYSDGA DDMPDFHDEG EFDDYLNDDE YDLMNEVFPT LKAQLQDYQG WDNLSLKLAL  60
   61 FDNNFDLEST LAELKKTLKK KKTPKKPIAA ANGSANVTQK LANISISQQR PNDRLPDWLD 120
  121 EEESEGERNG EEANDEKTVQ RYYKTTVPTK PKKPHDISAF VKSALPHLSF VVLGHVDAGK 180
  181 STLMGRLLYD LNIVNQSQLR KLQRESETMG KSSFKFAWIM DQTNEERERG VTVSICTSHF 240
  241 STHRANFTIV DAPGHRDFVP NAIMGISQAD MAILCVDCST NAFESGFDLD GQTKEHMLLA 300
  301 SSLGIHNLII AMNKMDNVDW SQQRFEEIKS KLLPYLVDIG FFEDNINWVP ISGFSGEGVY 360
  361 KIEYTDEVRQ WYNGPNLMST LENAAFKISK ENEGINKDDP FLFSVLEIIP SKKTSNDLAL 420
  421 VSGKLESGSI QPGESLTIYP SEQSCIVDKI QVGSQQGQST NHEETDVAIK GDFVTLKLRK 480
  481 AYPEDIQNGD LAASVDYSSI HSAQCFVLEL TTFDMNRPLL PGTPFILFIG VKEQPARIKR 540
  541 LISFIDKGNT ASKKKIRHLG SKQRAFVEIE LIEVKRWIPL LTAHENDRLG RVVLRKDGRT 600
  601 IAAGKISEIT Q

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	(MIPS) Mewes HW, et al. (2004)		CAM1 EFB1 HBS1 TEF1, TEF2 TEF4

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	RIX1	No Comments	Hazbun TR, et al. (2003)
View Run	CEP3	sample cbf3 from feb 2005	Sandall S, et all (2006)
View Run	MLP2	#29 Asynchronous Prep5-TiO2 Flowthrough	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	CCE1	HBS1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

New Feature: Upload Your Own Microscopy Data

	PROTEIN(S)	PUBLICATION
View Data	HBS1	Huh WK, et al. (2003)

Protein Structure Data

[What does the above image mean?]
[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..152]	MSA	3.590996	View MSA. No confident structure predictions are available.
2	View Details	[153..393]	PSI-BLAST	1580.0	Elongation factor eEF-1alpha, domain 2; Elongation factor eEF-1alpha, C-terminal domain; Elongation factor eEF-1alpha, N-terminal (G) domain
3	View Details	[394..500]	PSI-BLAST	1580.0	Elongation factor eEF-1alpha, domain 2; Elongation factor eEF-1alpha, C-terminal domain; Elongation factor eEF-1alpha, N-terminal (G) domain
4	View Details	[501..611]	PSI-BLAST	1580.0	Elongation factor eEF-1alpha, domain 2; Elongation factor eEF-1alpha, C-terminal domain; Elongation factor eEF-1alpha, N-terminal (G) domain

Functions predicted (by domain):

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
translation elongation factor activity	8.90683166637832	bayes_pls_golite062009
translation factor activity, nucleic acid binding	4.8378725567094	bayes_pls_golite062009
translation regulator activity	4.79814772079421	bayes_pls_golite062009
actin binding	2.84620358490972	bayes_pls_golite062009
cytoskeletal protein binding	2.66896300219871	bayes_pls_golite062009
binding	2.64537357529343	bayes_pls_golite062009
hydrolase activity	2.55157966585974	bayes_pls_golite062009
actin filament binding	2.1683792904715	bayes_pls_golite062009
motor activity	1.64238426331767	bayes_pls_golite062009
nucleic acid binding	1.49633029954726	bayes_pls_golite062009
purine ribonucleotide binding	1.2935968641033	bayes_pls_golite062009
ribonucleotide binding	1.2935353851804	bayes_pls_golite062009
purine nucleotide binding	1.29138695385133	bayes_pls_golite062009
nucleotide binding	1.28669586915546	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
transcription regulator activity	0.989226939888218	bayes_pls_golite062009
ATP binding	0.98146619596929	bayes_pls_golite062009
DNA binding	0.967303417236485	bayes_pls_golite062009
adenyl ribonucleotide binding	0.949788783884952	bayes_pls_golite062009
adenyl nucleotide binding	0.931486373329219	bayes_pls_golite062009
protein methyltransferase activity	0.876296121718575	bayes_pls_golite062009
microtubule motor activity	0.87576779858246	bayes_pls_golite062009
structural constituent of ribosome	0.860102064846772	bayes_pls_golite062009
microfilament motor activity	0.842051467704019	bayes_pls_golite062009
RNA binding	0.715902454627085	bayes_pls_golite062009
kinase activity	0.691112783105676	bayes_pls_golite062009
histone methyltransferase activity	0.63002958837536	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.499834566483656	bayes_pls_golite062009
	0.3172470686972	bayes_pls_golite062009
ribonuclease activity	0.222424272323909	bayes_pls_golite062009
protein binding	0.170837278876362	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.147579541298736	bayes_pls_golite062009
pyrophosphatase activity	0.133017653323467	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.113504049290503	bayes_pls_golite062009
structural molecule activity	0.11239762372728	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.111293884322157	bayes_pls_golite062009
helicase activity	0.0775311459068899	bayes_pls_golite062009
transcription factor activity	0.0434163635422169	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.0430764033739892	bayes_pls_golite062009
protein kinase activity	0.0364322017534667	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2