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Protein Overview: SOD2

General Information:
Name(s) found: SOD2 / YHR008C [SGD]
Description(s) found:
Found 31 descriptions.
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  • Mitochondrial superoxide dismutase, protects cells against oxygen toxicity; phosphorylated [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 233 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial matrix [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    Biological Process: age-dependent response to reactive oxygen species involved in chronological cell aging [IMPLink to PubMed article]
    oxygen and reactive oxygen species metabolic process [IMPLink to PubMed article]
    replicative cell aging [IMPLink to PubMed article]
    age-dependent response to oxidative stress involved in chronological cell aging [IMPLink to PubMed article]
    Molecular Function: metal ion binding [IEA]
    oxidoreductase activity [IEA]
    superoxide dismutase activity [IDA][IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFAKTAAANL TKKGGLSLLS TTARRTKVTL PDLKWDFGAL EPYISGQINE LHYTKHHQTY  60
   61 VNGFNTAVDQ FQELSDLLAK EPSPANARKM IAIQQNIKFH GGGFTNHCLF WENLAPESQG 120
  121 GGEPPTGALA KAIDEQFGSL DELIKLTNTK LAGVQGSGWA FIVKNLSNGG KLDVVQTYNQ 180
  181 DTVTGPLVPL VAIDAWEHAY YLQYQNKKAD YFKAIWNVVN WKEASRRFDA GKI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) GLN4 PBI2 PHO4 PRB1 SOD2 YNL019C
    View Details Ho Y, et al. (2002) APT1 ARO1 DSS1 ECM10 MTC5 OYE2 PRE1 PST2 PUP3 RAD1 RAD10 SOD2 TMA29 TPS1 TSA2 YHR033W YKU80

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SOD2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..233] PSI-BLAST 577.264245 Mn superoxide dismutase (MnSOD)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • superoxide dismutase activity
    		•  7.08472506566271 bayes_pls_golite062009
  • oxidoreductase activity, acting on superoxide radicals as acceptor
    		•  7.08472506566271 bayes_pls_golite062009
  • oxidoreductase activity
    		•  2.73079314406851 bayes_pls_golite062009
  • protein binding
    		•  1.36581969443298 bayes_pls_golite062009
  • binding
    		•  1.30562201415299 bayes_pls_golite062009
  • antioxidant activity
    		•  0.766723962166325 bayes_pls_golite062009
  • cation binding
    		•  0.485672227923388 bayes_pls_golite062009
  • metal ion binding
    		•  0.485672227923388 bayes_pls_golite062009
  • ion binding
    		•  0.480092270451566 bayes_pls_golite062009
  • catalytic activity
    		•  0.390489225704392 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.56

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle