YRC Public Data Repository - Protein Structure Prediction

Protein:	SOD2
Organism:	Saccharomyces cerevisiae
Length:	233 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SOD2.

Description	E-value	Query Range	Subject Range
SODM_HORSE - Superoxide dismutase [Mn], mitochondrial OS=Equus caballus GN=SOD2 PE=2 SV=1	9.0E-93	[1..232]	[1..221]
gi\|124126863, gi... - gi\|61360285\|gb\|AAX41838.1\| superoxide dismutase 2 mitochondrial [synthetic construct], gi\|61360280\|g... gi\|56204992, gi\|... - gi\|67782307\|ref\|NP_001019636.1\| manganese superoxide dismutase isoform A precursor [Homo sapiens], g...	3.0E-92	[1..232]	[1..221]
gi\|45383702, gi\|... - gi\|45383702\|ref\|NP_989542.1\| superoxide dismutase 2, mitochondrial [Gallus gallus], gi\|12034955\|gb\|A...	3.0E-92	[1..232]	[1..223]
SODM_MOUSE - Superoxide dismutase [Mn], mitochondrial OS=Mus musculus GN=Sod2 PE=1 SV=3 gi\|1037120 - gi\|1037120\|gb\|AAB34899.1\| manganese superoxide dismutase; MnSOD [Mus sp.]	9.0E-92	[1..232]	[1..221]
SODM_RAT - Superoxide dismutase [Mn], mitochondrial OS=Rattus norvegicus GN=Sod2 PE=1 SV=2	4.0E-91	[1..232]	[1..221]

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Predicted Domain #1

Region A:
Residues: [1-233]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFAKTAAANL TKKGGLSLLS TTARRTKVTL PDLKWDFGAL EPYISGQINE LHYTKHHQTY  60
   61 VNGFNTAVDQ FQELSDLLAK EPSPANARKM IAIQQNIKFH GGGFTNHCLF WENLAPESQG 120
  121 GGEPPTGALA KAIDEQFGSL DELIKLTNTK LAGVQGSGWA FIVKNLSNGG KLDVVQTYNQ 180
  181 DTVTGPLVPL VAIDAWEHAY YLQYQNKKAD YFKAIWNVVN WKEASRRFDA GKI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	577.264245
Match:	1kkcA_
Description:	Mn superoxide dismutase (MnSOD)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
superoxide dismutase activity	7.08472506566271	bayes_pls_golite062009
oxidoreductase activity, acting on superoxide radicals as acceptor	7.08472506566271	bayes_pls_golite062009
oxidoreductase activity	2.73079314406851	bayes_pls_golite062009
protein binding	1.36581969443298	bayes_pls_golite062009
binding	1.30562201415299	bayes_pls_golite062009
antioxidant activity	0.766723962166325	bayes_pls_golite062009
cation binding	0.485672227923388	bayes_pls_golite062009
metal ion binding	0.485672227923388	bayes_pls_golite062009
ion binding	0.480092270451566	bayes_pls_golite062009
catalytic activity	0.390489225704392	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: