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Protein Overview: CE38104

General Information:
Name(s) found: CE38104 [WormBase]
Description(s) found:
Found 18 descriptions.
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  • WBGene00020423 locus:prp-19 Pre-mRNA-processing factor 19 homolog status:Confirmed UniProt:Q10051 protein_id:CCD72869.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 492 amino acids

    Gene Ontology:
    Cellular Component: ubiquitin ligase complex [IEALink to PubMed article]
    Biological Process: collagen and cuticulin-based cuticle attachment to epithelium [IMPLink to PubMed article]
    hermaphrodite genitalia development [IMPLink to PubMed articleLink to PubMed article]
    morphogenesis of an epithelium [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    reproduction [IMPLink to PubMed article]
    protein ubiquitination [IEALink to PubMed article]
    Molecular Function: ubiquitin-protein ligase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFVCGISGE LTEDPVVSQV SGHIFDRRLI VKFIAENGTD PISHGELSED QLVSLKSGGT  60
   61 GSAPRNVSGT SIPSLLKMLQ DEWDTVMLNS FSLRQQLQIA RQELSHSLYQ HDAACRVISR 120
  121 LSKELTAARE ALSTLKPHTS AKVDDDVSID ESEDQQGLSE AILAKLEEKS KSLTAERKQR 180
  181 GKNLPEGLAK TEELAELKQT ASHTGIHSTG TPGITALDIK GNLSLTGGID KTVVLYDYEK 240
  241 EQVMQTFKGH NKKINAVVLH PDNITAISAS ADSHIRVWSA TDSSSKAIID VHQAPVTDIS 300
  301 LNASGDYILS ASDDSYWAFS DIRSGKSLCK VSVEPGSQIA VHSIEFHPDG LIFGTGAADA 360
  361 VVKIWDLKNQ TVAAAFPGHT AAVRSIAFSE NGYYLATGSE DGEVKLWDLR KLKNLKTFAN 420
  421 EEKQPINSLS FDMTGTFLGI GGQKVQVLHV KSWSEVVSLS DHSGPVTGVR FGENARSLVT 480
  481 CSLDKSLRVF SF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..67] PSI-BLAST 9.522879 Pre-mRNA splicing factor Prp19
    2 View Details [68..156] PSI-BLAST 34.221849 No description for 2pm7B was found.
    3 View Details [157..492] PSI-BLAST 74.0 beta1-subunit of the signal-transducing G protein heterotrimer

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  10.2497392096259 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  10.0460587929138 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  8.99384576623969 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  7.6988425139962 bayes_pls_golite062009
    		• 4.77196423114965 bayes_pls_golite062009
  • ligase activity
    		•  4.65189154176918 bayes_pls_golite062009
  • RNA binding
    		•  3.04658201081989 bayes_pls_golite062009
  • binding
    		•  2.78710909602478 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.72498741013971 bayes_pls_golite062009
  • protein binding
    		•  2.64803540957326 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.32387297115017 bayes_pls_golite062009
  • DNA binding
    		•  2.00904221080834 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.98209395225978 bayes_pls_golite062009
  • SMAD binding
    		•  1.93335489484338 bayes_pls_golite062009
  • ubiquitin-ubiquitin ligase activity
    		•  1.37401357060257 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.34503687064945 bayes_pls_golite062009
  • transcription factor activity
    		•  1.22579085356684 bayes_pls_golite062009
  • small conjugating protein-specific protease activity
    		•  1.2126425713931 bayes_pls_golite062009
  • transcription factor binding
    		•  1.11842175076436 bayes_pls_golite062009
  • ubiquitin-specific protease activity
    		•  1.03469202541773 bayes_pls_golite062009
  • copper ion binding
    		•  0.649716953783871 bayes_pls_golite062009
  • hydrolase activity
    		•  0.52386813728704 bayes_pls_golite062009
  • cysteine-type peptidase activity
    		•  0.50197530717959 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.384990496120483 bayes_pls_golite062009
  • SUMO polymer binding
    		•  0.33041248422054 bayes_pls_golite062009
  • cation binding
    		•  0.27118370366296 bayes_pls_golite062009
  • metal ion binding
    		•  0.27118370366296 bayes_pls_golite062009
  • ubiquitin thiolesterase activity
    		•  0.265769062717221 bayes_pls_golite062009
  • ion binding
    		•  0.265633945008889 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.233838999434784 bayes_pls_golite062009
  • transition metal ion binding
    		•  0.219773564054437 bayes_pls_golite062009
  • catalytic activity
    		•  0.14112008370434 bayes_pls_golite062009
  • transcription activator activity
    		•  0.126093965701234 bayes_pls_golite062009
  • enzyme binding
    		•  0.104373352314595 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  7.6976390971701 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  7.38724968585043 bayes_pls_golite062009
    		• 6.67009948605948 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  6.41826641115519 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  5.36089569430187 bayes_pls_golite062009
  • GTPase activity
    		•  4.02994814377904 bayes_pls_golite062009
  • RNA binding
    		•  3.77273677738815 bayes_pls_golite062009
  • snoRNA binding
    		•  2.69983094099712 bayes_pls_golite062009
  • structural molecule activity
    		•  2.6914565031145 bayes_pls_golite062009
  • ligase activity
    		•  2.55043310798974 bayes_pls_golite062009
  • binding
    		•  2.42570478946173 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.3610959773142 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.30918780727915 bayes_pls_golite062009
  • translation initiation factor activity
    		•  2.29806492548141 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.29049708962212 bayes_pls_golite062009
  • protein binding
    		•  2.26925404328312 bayes_pls_golite062009
  • dynactin binding
    		•  2.07556426531897 bayes_pls_golite062009
  • DNA binding
    		•  1.71685536470455 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.41752877005447 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.26395898062853 bayes_pls_golite062009
  • transporter activity
    		•  1.17433526848815 bayes_pls_golite062009
  • receptor activity
    		•  1.12819778129653 bayes_pls_golite062009
  • G-protein-coupled receptor binding
    		•  1.11754260203517 bayes_pls_golite062009
  • actin binding
    		•  1.08902852052152 bayes_pls_golite062009
  • transcription factor activity
    		•  1.08768505897883 bayes_pls_golite062009
  • mRNA binding
    		•  1.05053985350578 bayes_pls_golite062009
  • actin filament binding
    		•  0.976656531652978 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.974380908248463 bayes_pls_golite062009
  • signal transducer activity
    		•  0.974380908248463 bayes_pls_golite062009
  • type 1 angiotensin receptor binding
    		•  0.920323565472959 bayes_pls_golite062009
  • angiotensin receptor binding
    		•  0.920323565472959 bayes_pls_golite062009
  • kinase activity
    		•  0.807669232329985 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.805273887494167 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.703671430935754 bayes_pls_golite062009
  • dynein binding
    		•  0.67053085134802 bayes_pls_golite062009
  • protein transporter activity
    		•  0.644350648477191 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.634547834947756 bayes_pls_golite062009
  • protein kinase activity
    		•  0.544118712921054 bayes_pls_golite062009
  • transcription factor binding
    		•  0.489473003915035 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.446034974847705 bayes_pls_golite062009
  • tubulin binding
    		•  0.418259033722167 bayes_pls_golite062009
  • microtubule binding
    		•  0.360612852884949 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.30761651528651 bayes_pls_golite062009
  • hydrolase activity
    		•  0.181211933860468 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.161639372576406 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.0803897416817422 bayes_pls_golite062009
  • receptor binding
    		•  0.0390635451962911 bayes_pls_golite062009
  • kinase binding
    		•  0.0366162235750993 bayes_pls_golite062009
  • protein kinase binding
    		•  0.00858004043229577 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle