YRC Public Data Repository - Protein Structure Prediction

Protein:	YECC_ECOLI
Organism:	Escherichia coli
Length:	250 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YECC_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|56420511, gi\|... - gi\|56420511\|ref\|YP_147829.1\| glutamine ABC transporter ATP-binding protein [Geobacillus kaustophilus...	327.0	[0..3]	[250..1]
GLNQ_GEOSE - Glutamine transport ATP-binding protein GlnQ OS=Geobacillus stearothermophilus GN=glnQ PE=2 SV=1	326.0	[0..3]	[250..1]
gi\|83595860 - gi\|83595860\|gb\|ABC25222.1\| amino acid ABC transporter, ATP-binding protein [uncultured marine bacter...	325.0	[0..4]	[250..14]
gi\|45548601, gi\|... - ref\|ZP_00188632.1\| COG1126: ABC-type polar amino acid transport system, ATPase component [Rubrobacte...	324.0	[0..1]	[248..1]
gi\|89099966, gi\|... - gi\|89099966\|ref\|ZP_01172837.1\| glutamine ABC transporter ATP-binding protein [Bacillus sp. NRRL B-14...	324.0	[0..1]	[248..1]
gi\|82724967, gi\|... - gi\|82747099\|ref\|ZP_00909599.1\| ATPas [Clostridium beijerincki NCIMB 8052], gi\|82724967\|gb\|EAP59716.1...	324.0	[0..3]	[248..1]
gi\|11528330 - gi\|11528330\|gb\|AAG37225.1\|AF298223_3 glutamine ABC transporter, ATP-binding subunit [Methanococcus m... gi\|45047352, gi\|... - gi\|45357792\|ref\|NP_987349.1\| amino acid ABC transporter ATP-binding protein [Methanococcus maripalud...	324.0	[0..3]	[250..1]
gi\|194467497, gi... - gi\|92090286\|ref\|ZP_01275165.1\| ABC transporter related [Lactobacillus reuteri 100-23], gi\|91802944\|g...	324.0	[0..4]	[249..7]
gi\|222450603, gi... - gi\|222526724\|ref\|YP_002571195.1\| ABC transporter related [Chloroflexus sp. Y-400-fl], gi\|222450603\|g... gi\|163670063, gi... - gi\|76261358\|ref\|ZP_00768971.1\| ABC transporter related [Chloroflexus aurantiacus J-10-fl], gi\|761637...	324.0	[0..3]	[248..10]
gi\|55736670, gi\|... - gi\|55820685\|ref\|YP_139127.1\| polar amino acid ABC uptake transporter ATP-binding protein [Streptococ... gi\|55736670 - gb\|AAV60312.1\| polar amino acid ABC uptake transporter ATP-binding protein [Streptococcus thermophil... gi\|116627491, gi... - gi\|62528355\|ref\|ZP_00389609.1\| COG1126: ABC-type polar amino acid transport system, ATPase component...	323.0	[0..2]	[248..4]

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Predicted Domain #1

Region A:
Residues: [1-250]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAIEVKNLV KKFHGQTVLH GIDLEVKPGE VVAIIGPSGS GKTTLLRSIN LLEQPEAGTI  60
   61 TVGDITIDTA RSLSQQKSLI RQLRQHVGFV FQNFNLFPHR TVLENIIEGP VIVKGEPKEE 120
  121 ATARARELLA KVGLAGKETS YPRRLSGGQQ QRVAIARALA MRPEVILFDE PTSALDPELV 180
  181 GEVLNTIRQL AQEKRTMVIV THEMSFARDV ADRAIFMDQG RIVEQGAAKA LFADPEQPRT 240
  241 RQFLEKFLLQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	72.522879
Match:	1b0uA
Description:	ATP-binding subunit of the histidine permease
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
P-P-bond-hydrolysis-driven transmembrane transporter activity	6.58863529263644	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	6.58067278719409	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	6.57974651657836	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	6.57922174989907	bayes_pls_golite062009
primary active transmembrane transporter activity	6.57807080367604	bayes_pls_golite062009
nucleoside-triphosphatase activity	6.48406410175216	bayes_pls_golite062009
active transmembrane transporter activity	6.48154954364331	bayes_pls_golite062009
pyrophosphatase activity	6.40467109535527	bayes_pls_golite062009
ATPase activity, coupled	6.40151534181487	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	6.38373914253885	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	6.38247436082206	bayes_pls_golite062009
ATPase activity	6.30019941712404	bayes_pls_golite062009
peptide transporter activity	4.7442815698413	bayes_pls_golite062009
anion transmembrane-transporting ATPase activity	4.71935767060308	bayes_pls_golite062009
peptide-transporting ATPase activity	4.63590351019108	bayes_pls_golite062009
hydrolase activity	4.60957912556603	bayes_pls_golite062009
inorganic anion transmembrane transporter activity	4.35344629015015	bayes_pls_golite062009
oligopeptide-transporting ATPase activity	4.09365342567844	bayes_pls_golite062009
ribonucleotide binding	3.79710854336074	bayes_pls_golite062009
purine ribonucleotide binding	3.7956093726294	bayes_pls_golite062009
ATP binding	3.78352939926331	bayes_pls_golite062009
purine nucleotide binding	3.74676466237472	bayes_pls_golite062009
adenyl ribonucleotide binding	3.73153142187361	bayes_pls_golite062009
nucleotide binding	3.71970404557651	bayes_pls_golite062009
adenyl nucleotide binding	3.66815111788068	bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism	3.57926427233638	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	3.4837867129694	bayes_pls_golite062009
ion transmembrane transporter activity	3.35436118751376	bayes_pls_golite062009
phosphate transmembrane-transporting ATPase activity	3.20894563245332	bayes_pls_golite062009
phosphate transmembrane transporter activity	3.14373643903738	bayes_pls_golite062009
anion transmembrane transporter activity	3.13913638619234	bayes_pls_golite062009
transporter activity	3.10463051760206	bayes_pls_golite062009
cation transmembrane transporter activity	3.08390071341252	bayes_pls_golite062009
iron ion transmembrane transporter activity	3.05511942104215	bayes_pls_golite062009
transmembrane transporter activity	2.95886887664984	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	2.9271291809464	bayes_pls_golite062009
branched-chain aliphatic amino acid transmembrane transporter activity	2.88795687640992	bayes_pls_golite062009
amine-transporting ATPase activity	2.69529191205818	bayes_pls_golite062009
organic acid transmembrane transporter activity	2.67957846350199	bayes_pls_golite062009
carboxylic acid transmembrane transporter activity	2.67815672695824	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	2.63419811368692	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	2.40292717311506	bayes_pls_golite062009
amine transmembrane transporter activity	2.29486577878686	bayes_pls_golite062009
metal ion transmembrane transporter activity	2.26365379756656	bayes_pls_golite062009
oligopeptide transporter activity	2.05580564974083	bayes_pls_golite062009
molybdate ion transmembrane transporter activity	2.04724145339382	bayes_pls_golite062009
molybdate transmembrane-transporting ATPase activity	2.04724145339382	bayes_pls_golite062009
lipopolysaccharide-transporting ATPase activity	1.92426772294655	bayes_pls_golite062009
lipopolysaccharide transmembrane transporter activity	1.92426772294655	bayes_pls_golite062009
substrate-specific transporter activity	1.91091452720653	bayes_pls_golite062009
polysaccharide transmembrane transporter activity	1.87680514870933	bayes_pls_golite062009
transition metal ion transmembrane transporter activity	1.82177108193332	bayes_pls_golite062009
organic anion transmembrane transporter activity	1.76999970080179	bayes_pls_golite062009
protein transporter activity	1.71214667007262	bayes_pls_golite062009
amino acid transmembrane transporter activity	1.59627719545436	bayes_pls_golite062009
binding	1.54492996193398	bayes_pls_golite062009
phosphonate transmembrane transporter activity	1.40269234722336	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions	1.23799860254751	bayes_pls_golite062009
sulfate transmembrane-transporting ATPase activity	1.1220946941463	bayes_pls_golite062009
GTPase activity	1.05341575831759	bayes_pls_golite062009
dipeptide transporter activity	1.01130176523309	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
cation channel activity	0.997064416395892	bayes_pls_golite062009
potassium channel activity	0.843657228494419	bayes_pls_golite062009
copper ion transmembrane transporter activity	0.798934081014025	bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity	0.767424210804186	bayes_pls_golite062009
voltage-gated cation channel activity	0.688632087597536	bayes_pls_golite062009
guanyl nucleotide binding	0.640772201693186	bayes_pls_golite062009
guanyl ribonucleotide binding	0.63468044350616	bayes_pls_golite062009
GTP binding	0.621689261700018	bayes_pls_golite062009
voltage-gated channel activity	0.562664200036023	bayes_pls_golite062009
voltage-gated ion channel activity	0.559798751382976	bayes_pls_golite062009
vitamin transporter activity	0.492482773015923	bayes_pls_golite062009
L-aspartate transmembrane transporter activity	0.483217496906356	bayes_pls_golite062009
drug transmembrane transporter activity	0.38711726712063	bayes_pls_golite062009
kinase activity	0.300431561463583	bayes_pls_golite062009
gated channel activity	0.299411774392227	bayes_pls_golite062009
nucleic acid binding	0.223761285614869	bayes_pls_golite062009
proton-transporting ATPase activity, rotational mechanism	0.219473333671469	bayes_pls_golite062009
signal recognition particle binding	0.20866768220789	bayes_pls_golite062009
cholesterol transporter activity	0.20165628585345	bayes_pls_golite062009
protein kinase activity	0.194459978373898	bayes_pls_golite062009
ion channel activity	0.154779598791225	bayes_pls_golite062009
amino acid-transporting ATPase activity	0.147644650870465	bayes_pls_golite062009
channel activity	0.134817721656507	bayes_pls_golite062009
passive transmembrane transporter activity	0.134817721656507	bayes_pls_golite062009
substrate-specific channel activity	0.126911677161968	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.0689844878028699	bayes_pls_golite062009
cation-transporting ATPase activity	0.0536898657672154	bayes_pls_golite062009
motor activity	0.0492636236578701	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: