YRC Public Data Repository - Protein Structure Prediction

Protein:	CYDD_ECOLI
Organism:	Escherichia coli
Length:	588 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CYDD_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|20807317, gi\|... - gi\|20807317\|ref\|NP_622488.1\| ABC-type multidrug/protein/lipid transport system, ATPase component [Th... gi\|20807317 - gi\|20807317\|ref\|NP_622488.1\| ABC-type multidrug/protein/lipid transport system, ATPase component [Th...	535.0	[0..1]	[587..9]
gi\|110800402, gi... - gi\|110800402\|ref\|YP_694961.1\| ABC transporter, permease/ATP-binding protein [Clostridium perfringens...	532.0	[0..2]	[587..24]
gi\|110682877, gi... - gi\|110802376\|ref\|YP_697823.1\| uncharacterized ABC transporter, ATPase component [Clostridium perfrin...	532.0	[0..2]	[587..24]
gi\|18309509, gi\|... - gi\|18309509\|ref\|NP_561443.1\| ABC transporter [Clostridium perfringens str. 13], gi\|18144186\|dbj\|BAB8...	531.0	[0..2]	[587..24]
MSBA_SYNAS - Lipid A export ATP-binding/permease protein MsbA OS=Syntrophus aciditrophicus (strain SB) GN=msbA PE...	527.0	[0..9]	[587..20]
gi\|158321697, gi... - gi\|158321697\|ref\|YP_001514204.1\| ABC transporter related [Alkaliphilus oremlandii OhILAs], gi\|158141...	523.0	[0..4]	[585..35]
Y288_THEMA - Uncharacterized ABC transporter ATP-binding protein TM_0288 OS=Thermotoga maritima GN=TM_0288 PE=3 S... Y288_THEMA - Uncharacterized ABC transporter ATP-binding protein TM_0288 OS=Thermotoga maritima (strain ATCC 4358...	522.0	[0..4]	[585..19]
gi\|82749150, gi\|... - gi\|82749150\|ref\|ZP_00911616.1\| ATPas [Clostridium beijerincki NCIMB 8052], gi\|82722975\|gb\|EAP57758.1...	521.0	[0..6]	[586..2]
gi\|52785918, gi\|... - gi\|52785918\|ref\|YP_091747.1\| YfiC [Bacillus licheniformis ATCC 14580], gi\|52348420\|gb\|AAU41054.1\| Yf...	521.0	[0..4]	[585..21]
gi\|146297202, gi... - gi\|82500846\|ref\|ZP_00886240.1\| ATPas [Caldicellulosiruptor saccharolyticus DSM 8903], gi\|82401164\|gb...	521.0	[0..3]	[586..18]

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Predicted Domain #1

Region A:
Residues: [1-588]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNKSRQKELT RWLKQQSVIS QRWLNISRLL GFVSGILIIA QAWFMARILQ HMIMENIPRE  60
   61 ALLLPFTLLV LTFVLRAWVV WLRERVGYHA GQHIRFAIRR QVLDRLQQAG PAWIQGKPAG 120
  121 SWATLVLEQI DDMHDYYARY LPQMALAVSV PLLIVVAIFP SNWAAALILL GTAPLIPLFM 180
  181 ALVGMGAADA NRRNFLALAR LSGHFLDRLR GMETLRIFGR GEAEIESIRS ASEDFRQRTM 240
  241 EVLRLAFLSS GILEFFTSLS IALVAVYFGF SYLGELDFGH YDTGVTLAAG FLALILAPEF 300
  301 FQPLRDLGTF YHAKAQAVGA ADSLKTFMET PLAHPQRGEA ELASTDPVTI EAEELFITSP 360
  361 EGKTLAGPLN FTLPAGQRAV LVGRSGSGKS SLLNALSGFL SYQGSLRING IELRDLSPES 420
  421 WRKHLSWVGQ NPQLPAATLR DNVLLARPDA SEQELQAALD NAWVSEFLPL LPQGVDTPVG 480
  481 DQAARLSVGQ AQRVAVARAL LNPCSLLLLD EPAASLDAHS EQRVMEALNA ASLRQTTLMV 540
  541 THQLEDLADW DVIWVMQDGR IIEQGRYAEL SVAGGPFATL LAHRQEEI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	141.0
Match:	2hydA
Description:	No description for 2hydA was found.

Predicted functions:

Term	Confidence	Notes
lipid transporter activity	7.47642599298853	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	5.57844095962502	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	5.57813579764186	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	5.57813579764186	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	5.5689620139321	bayes_pls_golite062009
primary active transmembrane transporter activity	5.55992639965745	bayes_pls_golite062009
active transmembrane transporter activity	5.50005167063544	bayes_pls_golite062009
ATPase activity, coupled	4.98276715440477	bayes_pls_golite062009
ATPase activity	4.69795387297193	bayes_pls_golite062009
nucleoside-triphosphatase activity	4.45923622153365	bayes_pls_golite062009
pyrophosphatase activity	4.39781350157199	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	4.38133275795019	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4.38085303582726	bayes_pls_golite062009
transporter activity	3.71239480053329	bayes_pls_golite062009
ion transmembrane transporter activity	3.35436118751376	bayes_pls_golite062009
hydrolase activity	3.14498892233323	bayes_pls_golite062009
transmembrane transporter activity	3.13960906549884	bayes_pls_golite062009
substrate-specific transporter activity	3.1318898376276	bayes_pls_golite062009
cation transmembrane transporter activity	3.08390071341252	bayes_pls_golite062009
ATP binding	3.01346604299372	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	3.00745742755195	bayes_pls_golite062009
drug transmembrane transporter activity	2.97119034312001	bayes_pls_golite062009
adenyl ribonucleotide binding	2.96271391116269	bayes_pls_golite062009
adenyl nucleotide binding	2.91131545957759	bayes_pls_golite062009
purine ribonucleotide binding	2.70262534541085	bayes_pls_golite062009
ribonucleotide binding	2.70178191749524	bayes_pls_golite062009
amine-transporting ATPase activity	2.69529191205818	bayes_pls_golite062009
organic acid transmembrane transporter activity	2.67957846350199	bayes_pls_golite062009
carboxylic acid transmembrane transporter activity	2.67815672695824	bayes_pls_golite062009
purine nucleotide binding	2.6583477492092	bayes_pls_golite062009
nucleotide binding	2.62374702628143	bayes_pls_golite062009
sterol transporter activity	2.48473697371886	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	2.40292717311506	bayes_pls_golite062009
amine transmembrane transporter activity	2.29486577878686	bayes_pls_golite062009
metal ion transmembrane transporter activity	2.26365379756656	bayes_pls_golite062009
	2.20174656498665	bayes_pls_golite062009
iron ion transmembrane transporter activity	2.14305203987289	bayes_pls_golite062009
anion transmembrane-transporting ATPase activity	2.12727614888121	bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism	2.1115517127743	bayes_pls_golite062009
inorganic anion transmembrane transporter activity	1.88153949603611	bayes_pls_golite062009
transition metal ion transmembrane transporter activity	1.82177108193332	bayes_pls_golite062009
protein transporter activity	1.71214667007262	bayes_pls_golite062009
amino acid transmembrane transporter activity	1.59627719545436	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	1.58971273330352	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	1.4343912580786	bayes_pls_golite062009
binding	1.39093533263371	bayes_pls_golite062009
peptide-transporting ATPase activity	1.37783759788533	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions	1.23799860254751	bayes_pls_golite062009
peptide transporter activity	1.19353064661766	bayes_pls_golite062009
GTPase activity	1.05341575831759	bayes_pls_golite062009
cation channel activity	0.997064416395892	bayes_pls_golite062009
copper ion transmembrane transporter activity	0.798934081014025	bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity	0.767424210804186	bayes_pls_golite062009
voltage-gated cation channel activity	0.688632087597536	bayes_pls_golite062009
cholesterol transporter activity	0.644421039250979	bayes_pls_golite062009
guanyl nucleotide binding	0.640772201693186	bayes_pls_golite062009
guanyl ribonucleotide binding	0.63468044350616	bayes_pls_golite062009
GTP binding	0.621689261700018	bayes_pls_golite062009
voltage-gated channel activity	0.562664200036023	bayes_pls_golite062009
voltage-gated ion channel activity	0.559798751382976	bayes_pls_golite062009
branched-chain aliphatic amino acid transmembrane transporter activity	0.442220326523999	bayes_pls_golite062009
anion transmembrane transporter activity	0.43332053110728	bayes_pls_golite062009
potassium channel activity	0.329290830676079	bayes_pls_golite062009
gated channel activity	0.299411774392227	bayes_pls_golite062009
signal recognition particle binding	0.20866768220789	bayes_pls_golite062009
ion channel activity	0.154779598791225	bayes_pls_golite062009
amino acid-transporting ATPase activity	0.147644650870465	bayes_pls_golite062009
passive transmembrane transporter activity	0.134817721656507	bayes_pls_golite062009
channel activity	0.134817721656507	bayes_pls_golite062009
substrate-specific channel activity	0.126911677161968	bayes_pls_golite062009
cation-transporting ATPase activity	0.0536898657672154	bayes_pls_golite062009
motor activity	0.0492636236578701	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: