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View Structure Prediction Details

Protein: cul-6
Organism: Caenorhabditis elegans
Length: 729 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cul-6.

Description E-value Query
Range
Subject
Range
gi|50733451 - gi|50733451|ref|XP_418878.1| PREDICTED: similar to Cullin homolog 1 (CUL-1) [Gallus gallus]
703.0 [0..1] [729..221]

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Predicted Domain #1
Region A:
Residues: [1-729]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSIEAVWGTL QDGLNLLYRR EHMSKKYYMM LYDAVYNICT TTTLANSNNN SPEFASEFLY  60
   61 KQLENYIRTY VIAIRDRISA CSGDELLGKC TIEWDNFKFS TRICNCIFQY LNRNFVSKKV 120
  121 EDKNGEIVEI YKLALDIWKA EFFDNFKVKT IDAILELILL ERCGSTINST HISSVVECLT 180
  181 ELDIYKVSFE PQFLDATKLF YKQEVLNSKE TVIEYMITVE NRLFQEEYRS RRYLGPSTND 240
  241 LLIDSCESIL ISDRLKFLHS EFERLLEARK DEHLTRMYSL CRRVTHGLED LRVYLEKRIL 300
  301 KEGHETLQRL AKDSGLKTTP KEYITKLLEV HEIYFNLINK AFDRNALFMQ SLDKASKDFI 360
  361 EANAVTMLAP EKHRSTRSAD YLARYCDQLL KKNSKVQDET ALDKALTVLK YISEKDVFQL 420
  421 YYQNWFSERI INNSSASDDA EEKFITNLTA TEGLEYTRNL VKMVEDAKIS KDLTTEFKDI 480
  481 KTEKSIDFNV ILQTTGAWPS LDQIKIILPR ELSTILKEFD TFYNASHNGR RLNWAYSQCR 540
  541 GEVNSKAFEK KYVFIVTASQ LCTLYLFNEQ DSFTIEQISK AIEMTAKSTS AIVGSLNPVI 600
  601 DPVLVVDKGN EKDGYPPDAV VSLNTKYANK KVRVDLTTAI KKATADRETD AVQNTVESDR 660
  661 KYEIKACIVR IMKTRKSLTH TLLINEIISQ LKSRFTPNVQ MIKICIEILI EQLYIRRSEN 720
  721 EHNVYEYLA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1000.0
Match: 1u6gA
Description: Crystal Structure of The Cand1-Cul1-Roc1 Complex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ubiquitin-protein ligase activity 9.95820721075934 bayes_pls_golite062009
small conjugating protein ligase activity 9.63704265478699 bayes_pls_golite062009
acid-amino acid ligase activity 8.59660059921406 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 7.32718329074249 bayes_pls_golite062009
vasopressin activated calcium mobilizing receptor activity 6.69190468636718 bayes_pls_golite062009
transcription regulator activity 5.55329976718261 bayes_pls_golite062009
transcription factor activity 4.33152142980289 bayes_pls_golite062009
ligase activity 4.08678005991666 bayes_pls_golite062009
transcription repressor activity 3.85678231380989 bayes_pls_golite062009
binding 2.45185337633142 bayes_pls_golite062009
transcription activator activity 2.37668609508629 bayes_pls_golite062009
protein binding 2.34145982999922 bayes_pls_golite062009
nucleic acid binding 2.21939548334548 bayes_pls_golite062009
DNA binding 2.06132216820898 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.70025468248325 bayes_pls_golite062009
structure-specific DNA binding 1.33374581364046 bayes_pls_golite062009
specific transcriptional repressor activity 0.96257232341735 bayes_pls_golite062009
transporter activity 0.891050405674973 bayes_pls_golite062009
transcription factor binding 0.85714789329232 bayes_pls_golite062009
DNA replication origin binding 0.71823621709622 bayes_pls_golite062009
DNA-dependent ATPase activity 0.697234220778482 bayes_pls_golite062009
transmembrane transporter activity 0.648150681919233 bayes_pls_golite062009
substrate-specific transporter activity 0.368917395770011 bayes_pls_golite062009
catalytic activity 0.351553138703956 bayes_pls_golite062009
transcription corepressor activity 0.322180400748724 bayes_pls_golite062009
DNA helicase activity 0.300899564141452 bayes_pls_golite062009
double-stranded DNA binding 0.286130392009263 bayes_pls_golite062009
structural molecule activity 0.272316540117209 bayes_pls_golite062009
sequence-specific DNA binding 0.257777071965243 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.249771970501337 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.175575779922515 bayes_pls_golite062009
hydrolase activity 0.140191206949582 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.107671044044222 bayes_pls_golite062009
structural constituent of ribosome 0.0912115683429473 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.0856082199488197 bayes_pls_golite062009
transferase activity 0.064832527337659 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
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