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View Structure Prediction Details

Protein: cul1
Organism: Schizosaccharomyces pombe
Length: 767 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cul1.

Description E-value Query
Range
Subject
Range
gi|114197437, gi... - gi|115491899|ref|XP_001210577.1| cullin-1 [Aspergillus terreus NIH2624], gi|114197437|gb|EAU39137.1|...
788.0 [0..12] [767..6]
gi|74150930 - gi|74150930|dbj|BAE27601.1| unnamed protein product [Mus musculus]
783.0 [0..4] [767..1]
gi|73978425 - gi|73978425|ref|XP_848402.1| PREDICTED: similar to Cullin-1 (CUL-1) isoform 3 [Canis familiaris]
tr|F1MYD0|F1MYD0... - Uncharacterized protein OS=Bos taurus GN=CUL1 PE=3 SV=2
gi|194210081 - gi|194210081|ref|XP_001504677.2| PREDICTED: similar to SCF complex protein cul-1 isoform 1 [Equus ca...
781.0 [0..4] [767..1]
CUL1 - cullin 1
CUL1_PONPY - Cullin-1 - Pongo pygmaeus (Orangutan)
CUL1_PONAB - Cullin-1 OS=Pongo abelii GN=CUL1 PE=2 SV=1
gi|114616601, gi... - gi|114616611|ref|XP_001165597.1| PREDICTED: cullin 1 isoform 12 [Pan troglodytes], gi|114616609|ref|...
780.0 [0..4] [767..1]
gi|148224080, gi... - gi|62471560|gb|AAH93534.1| MGC115014 protein [Xenopus laevis], gi|148224080|ref|NP_001089364.1| hypo...
779.0 [0..4] [767..1]
gi|92919088, gi|... - gi|92919088|gb|ABE96895.1| cullin-1 [Xenopus tropicalis], gi|113931606|ref|NP_001039255.1| cullin 1 ...
779.0 [0..4] [767..1]
gi|169158288, gi... - gi|45433528|ref|NP_955953.2| cullin 1 [Danio rerio], gi|42542528|gb|AAH66480.1| Cullin 1a [Danio rer...
778.0 [0..4] [767..1]

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Predicted Domain #1
Region A:
Residues: [1-767]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTLNTNDKD LPIVKKYDSL NGTWDFLKTG VSQIFERLDE GMTITKYMEL YTAIHNYCAD  60
   61 ASKTITVDNF NDQTANVLGE ALYNNLVLYL EEYLARLRKE CISQTNHEEQ LAAYAKYWTR 120
  121 FTTSARFINH LFGYLNRYWV KLKNRFTETL VYDIYTLCLV SWHHHVFSHI RDSLLQNLLY 180
  181 MFTKKRLYEP TDMKYVEVCV DSITSLSFDK TDMTKPNLSS YKTFFETNFI ENTKNFYAKE 240
  241 SSEYLASHSI TDYLKKAEIR LAEEEELVRL YLHESTLKPL LEATEDVLIA QHEEVLHNDF 300
  301 ARMLDQNCSE DIIRMYRLMS RTPNGLQPLR QTFEEFVKRS GFAAVAKIVP QVGGEADVDP 360
  361 KEYMEMLLST YKASKELVNT AFHGDTDFTK SLDTAFRELV NRNVVCQRSS SRSPELLAKY 420
  421 ADSILRKSNK NVDIDDVEDC LSSIIIIFRY VEDKDVFQNF YTKLLAKRLV NGTSNSQDAE 480
  481 SSMLSKLKEV CGFEYTSKLQ RMFQDISLSQ EITEAFWQLP QSRAGNIDFS ALVLGTSFWP 540
  541 LSPNNVNFHL PEELVPLYEG FQNYYYSCHN GRKLSWLFHL SKGEIKARIN PQTNVTYVFQ 600
  601 VSTYQMGVLL LYNHRDSYTY EELAKITGLS TDFLTGILNI FLKAKVLLLG DNDKLGDPNS 660
  661 TYKINENFRM KKIRVQLNLP IRSEQKQESL ETHKTIEEDR KLLLQSAIVR IMKARRTLKH 720
  721 VVLVKETIDQ IKSRFTPKVS DIKQCIDMLI EKEYLERQGR DEYIYLA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1000.0
Match: 1u6gA
Description: Crystal Structure of The Cand1-Cul1-Roc1 Complex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ubiquitin-protein ligase activity 9.47178230940453 bayes_pls_golite062009
small conjugating protein ligase activity 9.15192834197166 bayes_pls_golite062009
acid-amino acid ligase activity 8.12051073361876 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 6.87003086224111 bayes_pls_golite062009
vasopressin activated calcium mobilizing receptor activity 6.55844152294696 bayes_pls_golite062009
transcription regulator activity 5.55329976718261 bayes_pls_golite062009
transcription factor activity 4.33152142980289 bayes_pls_golite062009
transcription repressor activity 3.85678231380989 bayes_pls_golite062009
ligase activity 3.66453881539688 bayes_pls_golite062009
transcription activator activity 2.37668609508629 bayes_pls_golite062009
binding 2.3219000606044 bayes_pls_golite062009
nucleic acid binding 2.21939548334548 bayes_pls_golite062009
protein binding 2.20237620151495 bayes_pls_golite062009
DNA binding 2.06132216820898 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.70025468248325 bayes_pls_golite062009
structure-specific DNA binding 1.33374581364046 bayes_pls_golite062009
specific transcriptional repressor activity 0.96257232341735 bayes_pls_golite062009
transporter activity 0.891050405674973 bayes_pls_golite062009
transcription factor binding 0.85714789329232 bayes_pls_golite062009
DNA replication origin binding 0.71823621709622 bayes_pls_golite062009
DNA-dependent ATPase activity 0.697234220778482 bayes_pls_golite062009
transmembrane transporter activity 0.648150681919233 bayes_pls_golite062009
substrate-specific transporter activity 0.368917395770011 bayes_pls_golite062009
transcription corepressor activity 0.322180400748724 bayes_pls_golite062009
DNA helicase activity 0.300899564141452 bayes_pls_golite062009
double-stranded DNA binding 0.286130392009263 bayes_pls_golite062009
structural molecule activity 0.272316540117209 bayes_pls_golite062009
sequence-specific DNA binding 0.257777071965243 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.249771970501337 bayes_pls_golite062009
catalytic activity 0.201606344181603 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.175575779922515 bayes_pls_golite062009
hydrolase activity 0.140191206949582 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.107671044044222 bayes_pls_golite062009
structural constituent of ribosome 0.0912115683429473 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.0856082199488197 bayes_pls_golite062009
transferase activity 0.064832527337659 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle