YRC Public Data Repository - Protein Structure Prediction

Protein:	GUK1
Organism:	Homo sapiens
Length:	197 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GUK1.

Description	E-value	Query Range	Subject Range
gi\|68191615, gi\|... - gi\|69277738\|ref\|ZP_00613073.1\| ABC transporter [Mesorhizobium sp. BNC1], gi\|68191615\|gb\|EAN06271.1\| ...	5.0E-52	[1..196]	[26..216]
gi\|13473520, gi\|... - gi\|14024270\|dbj\|BAB50874.1\| sugar ABC transportor, ATP-binding protein [Mesorhizobium loti MAFF30309...	5.0E-52	[1..196]	[26..216]
Y3745_BRUSU - Putative ATP-binding protein BRA0745 OS=Brucella suis GN=BRA0745 PE=3 SV=1 Y3745_BRUSU - Putative ATP-binding protein BRA0745/BS1330_II0738 OS=Brucella suis biovar 1 (strain 1330) GN=BRA074... gi\|260567988\|ref... - SN-glycerol-3-phosphate transport ATP-binding protein UGPC [Brucella suis bv. 4 str. 40] gi\|161337615, gi... - gi\|161620804\|ref\|YP_001594690.1\| lactose transport ATP-binding protein lacK [Brucella canis ATCC 233... gi\|254703083 - gi\|254703083\|ref\|ZP_05164911.1\| lactose transport ATP-binding protein lacK [Brucella suis bv. 3 str....	9.0E-52	[1..197]	[26..217]
Y2787_BRUAB - Putative ATP-binding protein BruAb2_0487 OS=Brucella abortus GN=BruAb2_0487 PE=3 SV=1 gi\|256157580\|ref... - conserved hypothetical protein [Brucella ceti M490/95/1], lactose transport ATP-binding protein lacK... gi\|265986389\|ref... - conserved hypothetical protein [Brucella pinnipedialis M292/94/1], lactose transport ATP-binding pro... gi\|260544652\|ref... - SN-glycerol-3-phosphate transport ATP-binding protein UGPC [Brucella abortus NCTC 8038] gi\|25297135 - pir\|\|AG3577 SN-glycerol-3-phosphate transport ATP-binding protein ugpC BMEII0544 [imported] - Brucel... gi\|17984716, gi\|... - gi\|17988889\|ref\|NP_541522.1\| SN-glycerol-3-phosphate transport ATP-binding protein ugpC [Brucella me... gi\|256262347\|ref... - SN-glycerol-3-phosphate transport ATP-binding protein UGPC [Brucella melitensis bv. 2 str. 63/9] gi\|256043622\|ref... - conserved hypothetical protein [Brucella melitensis bv. 1 str. Rev.1], lactose transport ATP-binding... gi\|256256101\|ref... - conserved hypothetical protein [Brucella abortus bv. 9 str. C68], lactose transport ATP-binding prot... gi\|189021244, gi... - gi\|189022670\|ref\|YP_001932411.1\| SN-glycerol-3-phosphate transport ATP-binding protein UGPC [Brucell... Y2787_BRUAB - Putative ATP-binding protein BruAb2_0487 OS=Brucella abortus biovar 1 (strain 9-941) GN=BruAb2_0487 ... gi\|225686515, gi... - gi\|225686515\|ref\|YP_002734487.1\| ATP-binding transport protein smoK [Brucella melitensis ATCC 23457]... Y2993_BRUA2 - Putative ATP-binding protein BAB2_0493 OS=Brucella abortus (strain 2308) GN=BAB2_0493 PE=3 SV=1 gi\|225615718, gi... - gi\|225629222\|ref\|ZP_03787255.1\| ATP-binding transport protein smoK [Brucella ceti str. Cudo], gi\|225... gi\|254690916 - gi\|254690916\|ref\|ZP_05154170.1\| lactose transport ATP-binding protein lacK [Brucella abortus bv. 6 s... gi\|237787781, gi... - gi\|237816968\|ref\|ZP_04595960.1\| ATP-binding transport protein smoK [Brucella abortus str. 2308 A], g... gi\|254699961 - gi\|254699961\|ref\|ZP_05161789.1\| lactose transport ATP-binding protein lacK [Brucella suis bv. 5 str.... gi\|254698697 - gi\|254698697\|ref\|ZP_05160525.1\| lactose transport ATP-binding protein lacK [Brucella abortus bv. 2 s... gi\|254711005 - gi\|254711005\|ref\|ZP_05172816.1\| lactose transport ATP-binding protein lacK [Brucella pinnipedialis B... gi\|254705774 - gi\|254705774\|ref\|ZP_05167602.1\| lactose transport ATP-binding protein lacK [Brucella pinnipedialis M... gi\|261756941\|ref... - SN-glycerol-3-phosphate transport ATP-binding protein UGPC [Brucella sp. F5/99], lactose transport A... gi\|261220570\|ref... - conserved hypothetical protein [Brucella ceti B1/94], lactose transport ATP-binding protein lacK [Br... gi\|254732144 - gi\|254732144\|ref\|ZP_05190722.1\| lactose transport ATP-binding protein lacK [Brucella abortus bv. 4 s...	1.0E-51	[1..197]	[26..217]
gi\|17936034, gi\|... - gi\|17936034\|ref\|NP_532824.1\| ABC transporter, nucleotide binding/ATPase protein [Agrobacterium tumef... gi\|25297123, gi\|... - pir\|\|H97617 ABC transporter, ATP-binding protein VCA0602 [imported] - Agrobacterium tumefaciens (str...	1.0E-51	[1..196]	[26..216]
gi\|48835579 - ref\|ZP_00292578.1\| COG3842: ABC-type spermidine/putrescine transport systems, ATPase components [The... POTA_THEFY - Spermidine/putrescine import ATP-binding protein PotA OS=Thermobifida fusca (strain YX) GN=potA PE=3...	4.0E-51	[1..196]	[52..242]
gi\|27351499, gi\|... - gi\|27378352\|ref\|NP_769881.1\| ABC transporter ATP-binding protein [Bradyrhizobium japonicum USDA 110]...	4.0E-51	[1..196]	[47..237]
gi\|115253546, gi... - gi\|116248896\|ref\|YP_764737.1\| putative ATP-binding component of ABC transporter [Rhizobium leguminos...	5.0E-51	[1..196]	[26..216]
gi\|89068420, gi\|... - gi\|89068420\|ref\|ZP_01155823.1\| ABC transporter, ATP-binding protein [Oceanicola granulosus HTCC2516]...	6.0E-51	[1..197]	[26..217]

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Predicted Domain #1

Region A:
Residues: [1-197]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGPRPVVLS GPSGAGKSTL LKRLLQEHSG IFGFSVSHTT RNPRPGEENG KDYYFVTREV  60
   61 MQRDIAAGDF IEHAEFSGNL YGTSKVAVQA VQAMNRICVL DVDLQGVRNI KATDLRPIYI 120
  121 SVQPPSLHVL EQRLRQRNTE TEESLVKRLA AAQADMESSK EPGLFDVVII NDSLDQAYAE 180
  181 LKEALSEEIK KAQRTGA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	51.522879
Match:	1lvgA
Description:	Guanylate kinase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
hydrogen ion transporting ATP synthase activity, rotational mechanism	4.94368959158184	bayes_pls_golite062009
GTPase activity	4.06265232661098	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	4.00431985024242	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	3.88411242531695	bayes_pls_golite062009
nucleobase, nucleoside, nucleotide kinase activity	3.66392587433723	bayes_pls_golite062009
transporter activity	3.10463051760206	bayes_pls_golite062009
transmembrane transporter activity	2.95886887664984	bayes_pls_golite062009
nucleoside-triphosphatase activity	2.95079405147356	bayes_pls_golite062009
pyrophosphatase activity	2.87427509025394	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	2.85499564954033	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	2.85178667290149	bayes_pls_golite062009
binding	2.64537357529343	bayes_pls_golite062009
primary active transmembrane transporter activity	2.61775212528604	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	2.61467977505707	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	2.57552435627908	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	2.57107347424517	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	2.57054427875021	bayes_pls_golite062009
active transmembrane transporter activity	2.50494515048649	bayes_pls_golite062009
ATPase activity, coupled	2.43862163407966	bayes_pls_golite062009
motor activity	2.40267948113603	bayes_pls_golite062009
ATPase activity	2.39535714892224	bayes_pls_golite062009
nucleotide kinase activity	2.24094813695083	bayes_pls_golite062009
glutamate receptor binding	2.18149167417819	bayes_pls_golite062009
phosphotransferase activity, phosphate group as acceptor	1.96697952975573	bayes_pls_golite062009
substrate-specific transporter activity	1.91091452720653	bayes_pls_golite062009
microtubule motor activity	1.77441050776692	bayes_pls_golite062009
hydrolase activity	1.57549510726226	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.56325751172863	bayes_pls_golite062009
cytoskeletal protein binding	1.50574672650697	bayes_pls_golite062009
nucleic acid binding	1.08697924060619	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
guanylate kinase activity	0.98934362137863	bayes_pls_golite062009
ion transmembrane transporter activity	0.977237423302079	bayes_pls_golite062009
signal transducer activity	0.952448314982579	bayes_pls_golite062009
molecular transducer activity	0.952448314982579	bayes_pls_golite062009
purine nucleotide binding	0.929901285538132	bayes_pls_golite062009
nucleotide binding	0.922442819194247	bayes_pls_golite062009
purine ribonucleotide binding	0.920987930180051	bayes_pls_golite062009
ribonucleotide binding	0.920926158369519	bayes_pls_golite062009
peptide-transporting ATPase activity	0.911425383309011	bayes_pls_golite062009
actin binding	0.875514430441177	bayes_pls_golite062009
peptide transporter activity	0.73541731084591	bayes_pls_golite062009
DNA binding	0.702147676354075	bayes_pls_golite062009
cation transmembrane transporter activity	0.557919489256916	bayes_pls_golite062009
anion transmembrane-transporting ATPase activity	0.48775834126327	bayes_pls_golite062009
adenylate kinase activity	0.447752711852745	bayes_pls_golite062009
microfilament motor activity	0.415173945174069	bayes_pls_golite062009
ATP binding	0.41092997612902	bayes_pls_golite062009
adenyl ribonucleotide binding	0.385813421701492	bayes_pls_golite062009
adenyl nucleotide binding	0.377870145186619	bayes_pls_golite062009
transcription regulator activity	0.312171320541728	bayes_pls_golite062009
receptor activity	0.277332279568238	bayes_pls_golite062009
tubulin binding	0.264882086048416	bayes_pls_golite062009
inorganic anion transmembrane transporter activity	0.25714006331445	bayes_pls_golite062009
transmembrane receptor activity	0.243026482777117	bayes_pls_golite062009
proton-transporting ATPase activity, rotational mechanism	0.20818362273204	bayes_pls_golite062009
protein binding	0.170837278876362	bayes_pls_golite062009
microtubule binding	0.156470772916507	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	0.123304946374679	bayes_pls_golite062009
metal ion transmembrane transporter activity	0.0775601177068852	bayes_pls_golite062009
helicase activity	0.0775311459068899	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: