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View Structure Prediction Details

Protein: PDR12
Organism: Saccharomyces cerevisiae
Length: 1511 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PDR12.

Description E-value Query
Range
Subject
Range
gi|28828822 - gi|28828822|gb|AAO51417.1| similar to Dictyostelium discoideum (Slime mold). ABC transporter AbcG13
0.0 [1..1471] [475..1942]
AB33G_ARATH - ABC transporter G family member 33 OS=Arabidopsis thaliana GN=ABCG33 PE=2 SV=1
0.0 [10..1375] [6..1355]
gi|18152891 - gi|18152891|gb|AAK62810.2|AF227914_1 ATP-binding cassette transporter ABC1 [Venturia inaequalis]
0.0 [7..1499] [57..1545]
CDR4_CANAX - ABC transporter CDR4 OS=Candida albicans GN=CDR4 PE=3 SV=1
0.0 [2..1481] [7..1490]
AB32G_ORYSJ - ABC transporter G family member 32 OS=Oryza sativa subsp. japonica GN=ABCG32 PE=2 SV=1
gi|33242923 - gi|33242923|gb|AAQ01165.1| putative ATPase [Oryza sativa (japonica cultivar-group)]
0.0 [6..1388] [28..1408]
gi|23304858, gi|... - gi|23304858|emb|CAC59691.2| ABC-transporter [Filobasidiella neoformans], gi|18478280|emb|CAD21006.1|...
0.0 [6..1471] [76..1543]
gi|21748416 - gi|21748416|emb|CAD27790.1| drug resistance protein 1 [Candida dubliniensis]
0.0 [1..1476] [6..1498]
gi|445052, gi|295839 - gi|445052|prf||1908372A SNQ2 gene, gi|295839|emb|CAA47270.1| 169 kDa protein [Saccharomyces cerevisi...
0.0 [1..1473] [1..1483]

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Predicted Domain #1
Region A:
Residues: [1-85]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSTDEHIEK DISSRSNHDD DYANSVQSYA ASEGQVDNED LAATSQLSRH LSNILSNEEG  60
   61 IERLESMARV ISHKTKKEMD SFEIN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.753 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.728 a.60.9 lambda integrase-like, N-terminal domain
View Download 0.733 f.34.1 Mechanosensitive channel protein MscS (YggB), transmembrane region
View Download 0.646 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.612 a.29.4 RecG, N-terminal domain
View Download 0.609 a.126.1 Serum albumin-like
View Download 0.600 a.7.6 Ribosomal protein S20
View Download 0.530 a.118.1 ARM repeat
View Download 0.524 a.74.1 Cyclin-like
View Download 0.523 a.144.1 PABC (PABP) domain
View Download 0.501 a.144.1 PABC (PABP) domain
View Download 0.491 a.3.1 Cytochrome c
View Download 0.476 a.46.1 Methionine synthase domain
View Download 0.473 a.61.1 Retroviral matrix proteins
View Download 0.468 a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.468 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.463 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.461 a.48.3 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
View Download 0.461 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.457 a.156.1 S13-like H2TH domain
View Download 0.441 a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.433 a.39.1 EF-hand
View Download 0.414 a.8.2 Plasmid maintenance system epsilon/zeta, antidote epsilon subunit
View Download 0.412 a.156.1 S13-like H2TH domain
View Download 0.412 a.69.3 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain
View Download 0.406 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.370 a.39.1 EF-hand
View Download 0.367 a.64.1 Saposin
View Download 0.367 a.51.1 Cytochrome c oxidase subunit h
View Download 0.366 a.60.1 SAM/Pointed domain
View Download 0.365 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.364 a.24.17 Group V grass pollen allergen
View Download 0.358 a.112.1 Description not found.
View Download 0.353 a.1.1 Globin-like
View Download 0.347 a.24.4 Hemerythrin
View Download 0.347 a.57.1 Protein HNS-dependent expression A; HdeA
View Download 0.338 a.1.1 Globin-like
View Download 0.332 a.4.1 Homeodomain-like
View Download 0.330 a.21.1 HMG-box
View Download 0.329 a.4.5 "Winged helix" DNA-binding domain
View Download 0.326 a.22.1 Histone-fold
View Download 0.325 c.84.1 Phosphoglucomutase, first 3 domains
View Download 0.323 a.142.1 PTS-regulatory domain, PRD
View Download 0.320 a.4.5 "Winged helix" DNA-binding domain
View Download 0.318 a.4.5 "Winged helix" DNA-binding domain
View Download 0.318 a.181.1 Antibiotic binding domain of TipA-like multidrug resistance regulators
View Download 0.312 a.64.1 Saposin
View Download 0.305 a.4.5 "Winged helix" DNA-binding domain
View Download 0.300 a.163.1 Crustacean CHH/MIH/GIH neurohormone
View Download 0.299 f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.292 a.2.3 Chaperone J-domain
View Download 0.292 a.60.13 Putative methyltransferase TM0872, insert domain
View Download 0.289 a.2.11 Fe,Mn superoxide dismutase (SOD), N-terminal domain
View Download 0.288 d.58.25 Killer toxin KP6 alpha-subunit
View Download 0.287 a.4.1 Homeodomain-like
View Download 0.280 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.275 a.118.8 TPR-like
View Download 0.275 a.4.1 Homeodomain-like
View Download 0.264 a.5.3 N-terminal domain of phosphatidylinositol transfer protein sec14p
View Download 0.258 d.82.2 Frataxin-like
View Download 0.258 a.24.15 FAD-dependent thiol oxidase
View Download 0.256 a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.253 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.252 a.8.3 Families 57/38 glycoside transferase middle domain
View Download 0.245 a.50.1 Anaphylotoxins (complement system)
View Download 0.242 a.126.1 Serum albumin-like
View Download 0.239 a.64.1 Saposin
View Download 0.239 a.26.1 4-helical cytokines
View Download 0.233 a.1.1 Globin-like
View Download 0.231 a.17.1 p8-MTCP1
View Download 0.231 a.118.8 TPR-like
View Download 0.230 d.226.1 GIY-YIG endonuclease
View Download 0.229 a.5.6 Hypothetical protein MTH1615
View Download 0.227 a.4.1 Homeodomain-like
View Download 0.221 a.74.1 Cyclin-like
View Download 0.219 a.1.1 Globin-like
View Download 0.218 a.39.1 EF-hand
View Download 0.218 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.217 a.39.1 EF-hand
View Download 0.216 a.22.1 Histone-fold
View Download 0.215 a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.211 a.24.3 Cytochromes
View Download 0.209 a.26.1 4-helical cytokines
View Download 0.209 a.151.1 Glutamyl tRNA-reductase dimerization domain
View Download 0.209 a.30.2 Homodimeric domain of signal transducing histidine kinase
View Download 0.208 a.24.17 Group V grass pollen allergen
View Download 0.204 a.74.1 Cyclin-like
View Download 0.201 a.47.2 t-snare proteins

Predicted Domain #2
Region A:
Residues: [86-421]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLDFDLRSLL HYLRSRQLEQ GIEPGDSGIA FKNLTAVGVD ASAAYGPSVE EMFRNIASIP  60
   61 AHLISKFTKK SDVPLRNIIQ NCTGVVESGE MLFVVGRPGA GCSTFLKCLS GETSELVDVQ 120
  121 GEFSYDGLDQ SEMMSKYKGY VIYCPELDFH FPKITVKETI DFALKCKTPR VRIDKMTRKQ 180
  181 YVDNIRDMWC TVFGLRHTYA TKVGNDFVRG VSGGERKRVS LVEAQAMNAS IYSWDNATRG 240
  241 LDASTALEFA QAIRTATNMV NNSAIVAIYQ AGENIYELFD KTTVLYNGRQ IYFGPADKAV 300
  301 GYFQRMGWVK PNRMTSAEFL TSVTVDFENR TLDIKP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 122.38764
Match: 1jj7A_
Description: Peptide transporter Tap1, C-terminal ABC domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [422-838]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GYEDKVPKSS SEFEEYWLNS EDYQELLRTY DDYQSRHPVN ETRDRLDVAK KQRLQQGQRE  60
   61 NSQYVVNYWT QVYYCMIRGF QRVKGDSTYT KVYLSSFLIK ALIIGSMFHK IDDKSQSTTA 120
  121 GAYSRGGMLF YVLLFASVTS LAEIGNSFSS RPVIVKHKSY SMYHLSAESL QEIITEFPTK 180
  181 FVAIVILCLI TYWIPFMKYE AGAFFQYILY LLTVQQCTSF IFKFVATMSK SGVDAHAVGG 240
  241 LWVLMLCVYA GFVLPIGEMH HWIRWLHFIN PLTYAFESLV STEFHHREML CSALVPSGPG 300
  301 YEGISIANQV CDAAGAVKGN LYVSGDSYIL HQYHFAYKHA WRNWGVNIVW TFGYIVFNVI 360
  361 LSEYLKPVEG GGDLLLYKRG HMPELGTENA DARTASREEM MEALNGPNVD LEKVIAE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [839-866]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KDVFTWNHLD YTIPYDGATR KLLSDVFG

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [888-916]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LNVLAQRINM GVITGDMLVN AKPLPASFN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 156.154902
Match: 1mt0A_
Description: Haemolysin B ATP-binding protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
lipid transporter activity 7.47642599298853 bayes_pls_golite062009
lipopolysaccharide transmembrane transporter activity 5.90177503313326 bayes_pls_golite062009
lipopolysaccharide-transporting ATPase activity 5.90177503313326 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 5.57844095962502 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 5.57813579764186 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 5.57813579764186 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 5.5689620139321 bayes_pls_golite062009
primary active transmembrane transporter activity 5.55992639965745 bayes_pls_golite062009
active transmembrane transporter activity 5.50005167063544 bayes_pls_golite062009
polysaccharide transmembrane transporter activity 5.26442752745523 bayes_pls_golite062009
ATPase activity, coupled 4.98276715440477 bayes_pls_golite062009
ATPase activity 4.69795387297193 bayes_pls_golite062009
nucleoside-triphosphatase activity 4.45923622153365 bayes_pls_golite062009
sterol transporter activity 4.45355165759136 bayes_pls_golite062009
pyrophosphatase activity 4.39781350157199 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 4.38133275795019 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4.38085303582726 bayes_pls_golite062009
transporter activity 3.71239480053329 bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism 3.57926427233638 bayes_pls_golite062009
ion transmembrane transporter activity 3.35436118751376 bayes_pls_golite062009
hydrolase activity 3.14498892233323 bayes_pls_golite062009
transmembrane transporter activity 3.13960906549884 bayes_pls_golite062009
substrate-specific transporter activity 3.1318898376276 bayes_pls_golite062009
cation transmembrane transporter activity 3.08390071341252 bayes_pls_golite062009
iron ion transmembrane transporter activity 3.05511942104215 bayes_pls_golite062009
ATP binding 3.01346604299372 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 3.00745742755195 bayes_pls_golite062009
drug transmembrane transporter activity 2.97119034312001 bayes_pls_golite062009
adenyl ribonucleotide binding 2.96271391116269 bayes_pls_golite062009
adenyl nucleotide binding 2.91131545957759 bayes_pls_golite062009
branched-chain aliphatic amino acid transmembrane transporter activity 2.88795687640992 bayes_pls_golite062009
metal ion transmembrane transporter activity 2.88476360771975 bayes_pls_golite062009
cholesterol transporter activity 2.72457626066894 bayes_pls_golite062009
purine ribonucleotide binding 2.70262534541085 bayes_pls_golite062009
ribonucleotide binding 2.70178191749524 bayes_pls_golite062009
amine-transporting ATPase activity 2.69529191205818 bayes_pls_golite062009
organic acid transmembrane transporter activity 2.67957846350199 bayes_pls_golite062009
carboxylic acid transmembrane transporter activity 2.67815672695824 bayes_pls_golite062009
purine nucleotide binding 2.6583477492092 bayes_pls_golite062009
nucleotide binding 2.62374702628143 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 2.61311581579476 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 2.40292717311506 bayes_pls_golite062009
amine transmembrane transporter activity 2.29486577878686 bayes_pls_golite062009
2.20174656498665 bayes_pls_golite062009
eye pigment precursor transporter activity 2.19742277986318 bayes_pls_golite062009
apolipoprotein A-I binding 2.15656963765495 bayes_pls_golite062009
apolipoprotein receptor activity 2.15656963765495 bayes_pls_golite062009
syntaxin-13 binding 2.15656963765495 bayes_pls_golite062009
apolipoprotein A-I receptor activity 2.15656963765495 bayes_pls_golite062009
anion transmembrane-transporting ATPase activity 2.12727614888121 bayes_pls_golite062009
proton-transporting ATPase activity, rotational mechanism 1.95782378818812 bayes_pls_golite062009
inorganic anion transmembrane transporter activity 1.88153949603611 bayes_pls_golite062009
transition metal ion transmembrane transporter activity 1.82177108193332 bayes_pls_golite062009
fluconazole transporter activity 1.75428613304237 bayes_pls_golite062009
azole transporter activity 1.75428613304237 bayes_pls_golite062009
binding 1.64266915208623 bayes_pls_golite062009
amino acid transmembrane transporter activity 1.59627719545436 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 1.58971273330352 bayes_pls_golite062009
peptide-transporting ATPase activity 1.37783759788533 bayes_pls_golite062009
cation channel activity 1.33585529285301 bayes_pls_golite062009
signal recognition particle binding 1.23869719200594 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions 1.23799860254751 bayes_pls_golite062009
peptide transporter activity 1.19353064661766 bayes_pls_golite062009
potassium channel activity 1.17288958041707 bayes_pls_golite062009
GTPase activity 1.16964908174651 bayes_pls_golite062009
voltage-gated cation channel activity 1.00384984515681 bayes_pls_golite062009
nucleic acid binding 0.896078342024449 bayes_pls_golite062009
voltage-gated ion channel activity 0.889208591820696 bayes_pls_golite062009
voltage-gated channel activity 0.871525745291603 bayes_pls_golite062009
0.869999622006359 bayes_pls_golite062009
ion channel activity 0.848261056209476 bayes_pls_golite062009
passive transmembrane transporter activity 0.806331380134838 bayes_pls_golite062009
channel activity 0.806331380134838 bayes_pls_golite062009
substrate-specific channel activity 0.799997700906738 bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity 0.767424210804186 bayes_pls_golite062009
phospholipid transporter activity 0.755445322666929 bayes_pls_golite062009
motor activity 0.677658554107 bayes_pls_golite062009
gated channel activity 0.650050847753837 bayes_pls_golite062009
DNA-dependent ATPase activity 0.62832939629645 bayes_pls_golite062009
anion transmembrane transporter activity 0.43332053110728 bayes_pls_golite062009
catalytic activity 0.368034275052766 bayes_pls_golite062009
DNA binding 0.361518668029935 bayes_pls_golite062009
canalicular bile acid transmembrane transporter activity 0.301752323171649 bayes_pls_golite062009
neutral amino acid transmembrane transporter activity 0.227570438294493 bayes_pls_golite062009
G-protein coupled receptor activity 0.169034229773346 bayes_pls_golite062009
amino acid-transporting ATPase activity 0.147644650870465 bayes_pls_golite062009
signal transducer activity 0.144122328222529 bayes_pls_golite062009
molecular transducer activity 0.144122328222529 bayes_pls_golite062009
transcription regulator activity 0.133605084599819 bayes_pls_golite062009
microtubule motor activity 0.11674780318211 bayes_pls_golite062009
protein transporter activity 0.104820191623932 bayes_pls_golite062009
protein binding 0.071010918255742 bayes_pls_golite062009
cation-transporting ATPase activity 0.0536898657672154 bayes_pls_golite062009
structure-specific DNA binding 0.050232896280066 bayes_pls_golite062009
ribonucleoprotein binding 0.0181245554613096 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [867-887]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YVKPGKMTAL MGESGAGKTT L

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [917-1091]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RSCGYVAQAD NHMAELSVRE SLRFAAELRQ QSSVPLEEKY EYVEKIITLL GMQNYAEALV  60
   61 GKTGRGLNVE QRKKLSIGVE LVAKPSLLLF LDEPTSGLDS QSAWSIVQFM RALADSGQSI 120
  121 LCTIHQPSAT LFEQFDRLLL LKKGGKMVYF GDIGPNSETL LKYFERQSGM KCGVS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 156.154902
Match: 1mt0A_
Description: Haemolysin B ATP-binding protein
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [1092-1389]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ENPAEYILNC IGAGATASVN SDWHDLWLAS PECAAARAEV EELHRTLPGR AVNDDPELAT  60
   61 RFAASYMTQI KCVLRRTALQ FWRSPVYIRA KFFECVACAL FVGLSYVGVN HSVGGAIEAF 120
  121 SSIFMLLLIA LAMINQLHVF AYDSRELYEV REAASNTFHW SVLLLCHAAV ENFWSTLCQF 180
  181 MCFICYYWPA QFSGRASHAG FFFFFYVLIF PLYFVTYGLW ILYMSPDVPS ASMINSNLFA 240
  241 AMLLFCGILQ PREKMPAFWR RLMYNVSPFT YVVQALVTPL VHNKKVVCNP HEYNIMDP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [1390-1511]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSGKTCGEFL STYMDNNTGY LVNPTATENC QYCPYTVQDQ VVAKYNVKWD HRWRNFGFMW  60
   61 AYICFNIAAM LICYYVVRVK VWSLKSVLNF KKWFNGPRKE RHEKDTNIFQ TVPGDENKIT 120
  121 KK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.503 a.22.1 Histone-fold
View Download 0.543 a.7.1 Spectrin repeat
View Download 0.421 a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.545 f.34.1 Mechanosensitive channel protein MscS (YggB), transmembrane region
View Download 0.545 f.34.1 Mechanosensitive channel protein MscS (YggB), transmembrane region
View Download 0.543 a.7.1 Spectrin repeat
View Download 0.503 a.22.1 Histone-fold
View Download 0.421 a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.376 a.22.1 Histone-fold
View Download 0.376 a.22.1 Histone-fold
View Download 0.353 b.40.4 Nucleic acid-binding proteins
View Download 0.320 a.47.2 t-snare proteins
View Download 0.303 a.4.12 TrpR-like
View Download 0.277 i.11.1 Computational models partly based on NMR data
View Download 0.272 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.266 c.55.1 Actin-like ATPase domain
View Download 0.265 a.7.8 GAT domain
View Download 0.260 a.121.1 Tetracyclin repressor-like, C-terminal domain
View Download 0.250 a.74.1 Cyclin-like
View Download 0.209 a.23.2 Diol dehydratase, gamma subunit
View Download 0.204 a.45.1 Glutathione S-transferase (GST), C-terminal domain


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle