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View Structure Prediction Details

Protein: PDR10
Organism: Saccharomyces cerevisiae
Length: 1564 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PDR10.

Description E-value Query
Range		 Subject
Range
gi|28828822 - gi|28828822|gb|AAO51417.1| similar to Dictyostelium discoideum (Slime mold). ABC transporter AbcG13
 0.0 [7..1558] [485..1942]
AB33G_ARATH - ABC transporter G family member 33 OS=Arabidopsis thaliana GN=ABCG33 PE=2 SV=1
 0.0 [30..1460] [4..1354]
gi|18152891 - gi|18152891|gb|AAK62810.2|AF227914_1 ATP-binding cassette transporter ABC1 [Venturia inaequalis]
 0.0 [9..1564] [13..1511]
CDR4_CANAX - ABC transporter CDR4 OS=Candida albicans GN=CDR4 PE=3 SV=1
 0.0 [1..1557] [1..1480]
AB32G_ORYSJ - ABC transporter G family member 32 OS=Oryza sativa subsp. japonica GN=ABCG32 PE=2 SV=1
gi|33242923 - gi|33242923|gb|AAQ01165.1| putative ATPase [Oryza sativa (japonica cultivar-group)]
 0.0 [7..1472] [2..1406]
gi|23304858, gi|... - gi|23304858|emb|CAC59691.2| ABC-transporter [Filobasidiella neoformans], gi|18478280|emb|CAD21006.1|...
 0.0 [2..1558] [70..1543]
gi|21748416 - gi|21748416|emb|CAD27790.1| drug resistance protein 1 [Candida dubliniensis]
 0.0 [3..1563] [5..1498]
gi|445052, gi|295839 - gi|445052|prf||1908372A SNQ2 gene, gi|295839|emb|CAA47270.1| 169 kDa protein [Saccharomyces cerevisi...
 0.0 [8..1559] [2..1482]

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Predicted Domain #1
Region A:
Residues: [1-111] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLQAPSSSNS GLNQGNAAPD GPPNETQPYE GLDAAAQEEI KELARTLTSQ SSLLSQEKRI  60
   61 TGTGDPNTLT AASSSSLSRS IFASDIKGVN PILLDVNDPD YDETLDPRSE N

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [112-201] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FSSVRWVRNM AQICENDSDF YKPFSLGCAW KDLSASGDSA DITYQGTFGN MPIKYLKMSW  60
   61 RCISRRLFHR THGKSEDNDS GFQILKPMDG

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [223-256] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LKSISVNTHG FKISPDTIIT YNGFSNKEIK NHYR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 172.927757
Match: 1mt0A_
Description: Haemolysin B ATP-binding protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
P-P-bond-hydrolysis-driven transmembrane transporter activity 6.58863529263644 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 6.58067278719409 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 6.57974651657836 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 6.57922174989907 bayes_pls_golite062009
primary active transmembrane transporter activity 6.57807080367604 bayes_pls_golite062009
nucleoside-triphosphatase activity 6.48406410175216 bayes_pls_golite062009
active transmembrane transporter activity 6.48154954364331 bayes_pls_golite062009
pyrophosphatase activity 6.40467109535527 bayes_pls_golite062009
ATPase activity, coupled 6.40151534181487 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 6.38373914253885 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 6.38247436082206 bayes_pls_golite062009
ATPase activity 6.30019941712404 bayes_pls_golite062009
hydrolase activity 4.60957912556603 bayes_pls_golite062009
sterol transporter activity 4.45355165759136 bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism 3.57926427233638 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 3.4837867129694 bayes_pls_golite062009
purine ribonucleotide binding 3.40690615950081 bayes_pls_golite062009
ribonucleotide binding 3.40594996232845 bayes_pls_golite062009
purine nucleotide binding 3.3669118613715 bayes_pls_golite062009
ion transmembrane transporter activity 3.35436118751376 bayes_pls_golite062009
nucleotide binding 3.33248266870364 bayes_pls_golite062009
ATP binding 3.17398570826788 bayes_pls_golite062009
lipid transporter activity 3.14635082108971 bayes_pls_golite062009
adenyl ribonucleotide binding 3.12628113185041 bayes_pls_golite062009
transporter activity 3.10463051760206 bayes_pls_golite062009
cation transmembrane transporter activity 3.08390071341252 bayes_pls_golite062009
adenyl nucleotide binding 3.0710107594224 bayes_pls_golite062009
iron ion transmembrane transporter activity 3.05511942104215 bayes_pls_golite062009
drug transmembrane transporter activity 2.97119034312001 bayes_pls_golite062009
transmembrane transporter activity 2.95886887664984 bayes_pls_golite062009
metal ion transmembrane transporter activity 2.88476360771975 bayes_pls_golite062009
cholesterol transporter activity 2.72457626066894 bayes_pls_golite062009
amine-transporting ATPase activity 2.69529191205818 bayes_pls_golite062009
organic acid transmembrane transporter activity 2.67957846350199 bayes_pls_golite062009
carboxylic acid transmembrane transporter activity 2.67815672695824 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 2.61311581579476 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 2.40292717311506 bayes_pls_golite062009
amine transmembrane transporter activity 2.29486577878686 bayes_pls_golite062009
2.20174656498665 bayes_pls_golite062009
eye pigment precursor transporter activity 2.19742277986318 bayes_pls_golite062009
apolipoprotein A-I receptor activity 2.15656963765495 bayes_pls_golite062009
apolipoprotein receptor activity 2.15656963765495 bayes_pls_golite062009
syntaxin-13 binding 2.15656963765495 bayes_pls_golite062009
apolipoprotein A-I binding 2.15656963765495 bayes_pls_golite062009
anion transmembrane-transporting ATPase activity 2.12727614888121 bayes_pls_golite062009
binding 2.01755875920323 bayes_pls_golite062009
substrate-specific transporter activity 1.91091452720653 bayes_pls_golite062009
inorganic anion transmembrane transporter activity 1.88153949603611 bayes_pls_golite062009
transition metal ion transmembrane transporter activity 1.82177108193332 bayes_pls_golite062009
azole transporter activity 1.75428613304237 bayes_pls_golite062009
fluconazole transporter activity 1.75428613304237 bayes_pls_golite062009
amino acid transmembrane transporter activity 1.59627719545436 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 1.58971273330352 bayes_pls_golite062009
peptide-transporting ATPase activity 1.37783759788533 bayes_pls_golite062009
cation channel activity 1.33585529285301 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions 1.23799860254751 bayes_pls_golite062009
peptide transporter activity 1.19353064661766 bayes_pls_golite062009
potassium channel activity 1.17288958041707 bayes_pls_golite062009
voltage-gated cation channel activity 1.00384984515681 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
nucleic acid binding 0.896078342024449 bayes_pls_golite062009
voltage-gated ion channel activity 0.889208591820696 bayes_pls_golite062009
voltage-gated channel activity 0.871525745291603 bayes_pls_golite062009
0.869999622006359 bayes_pls_golite062009
ion channel activity 0.848261056209476 bayes_pls_golite062009
passive transmembrane transporter activity 0.806331380134838 bayes_pls_golite062009
channel activity 0.806331380134838 bayes_pls_golite062009
substrate-specific channel activity 0.799997700906738 bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity 0.767424210804186 bayes_pls_golite062009
phospholipid transporter activity 0.755445322666929 bayes_pls_golite062009
DNA-dependent ATPase activity 0.70364355116614 bayes_pls_golite062009
gated channel activity 0.650050847753837 bayes_pls_golite062009
branched-chain aliphatic amino acid transmembrane transporter activity 0.442220326523999 bayes_pls_golite062009
anion transmembrane transporter activity 0.43332053110728 bayes_pls_golite062009
DNA binding 0.361518668029935 bayes_pls_golite062009
canalicular bile acid transmembrane transporter activity 0.301752323171649 bayes_pls_golite062009
neutral amino acid transmembrane transporter activity 0.227570438294493 bayes_pls_golite062009
GTPase activity 0.20164416416912 bayes_pls_golite062009
G-protein coupled receptor activity 0.169034229773346 bayes_pls_golite062009
amino acid-transporting ATPase activity 0.147644650870465 bayes_pls_golite062009
motor activity 0.14734538548583 bayes_pls_golite062009
signal transducer activity 0.144122328222529 bayes_pls_golite062009
molecular transducer activity 0.144122328222529 bayes_pls_golite062009
transcription regulator activity 0.133605084599819 bayes_pls_golite062009
protein binding 0.071010918255742 bayes_pls_golite062009
cation-transporting ATPase activity 0.0536898657672154 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [202-222] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CINPGELLVV LGRPGAGCTT L

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [257-450] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GEVVYNAESD IHIPHLTVFQ TLYTVARLKT PRNRIKGVDR DTFAKHMTEV AMATYGLSHT  60
   61 ADTKVGNDFV RGVSGGERKR VSIAEVSICG SKFQCWDNAT RGLDSATALE FIKALKTQAT 120
  121 ITKSAATVAI YQCSKDAYDL FDKVCVLYDG YQIFFGPSKQ AKKYFQRMGY VCPERQTTAD 180
  181 YLTSITSPSE RIKD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 172.927757
Match: 1mt0A_
Description: Haemolysin B ATP-binding protein
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [451-711] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KDMVKHGIMI PQTAYEMNQY WIQSEEYKQL QVQVNKHLDT DSSQQREQIK NAHIAKQSKR  60
   61 ARPSSPYTVS FFLQVKYILI RDIWRIKNDP SIQLFTVLSH AAMALILGSM FYEVMLSTTT 120
  121 TTFYYRGAAI FFAILFNAFS SLLEIFSLYE TRPITEKHKT YSLYRPSADA FASTFSDVPT 180
  181 KLATAVTFNI PYYFLINLKR DAGAFFFYFL INIITVFAMS HLFRCIGSVS KTLPQAMVPA 240
  241 SVLLLAFAMY TGFAIPRVQM L

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [712-884] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GWSKWISYIN PLSYLFESLM INEFHGRNFP CAQYIPSGPN YVNATGDEVT CSALGSIPGN  60
   61 NYVSGDDFIQ TNYGYRHKNK WRSVGIGLAY IIFFLFLYLF FCEYNEGAKQ NGEMLVFPHS 120
  121 VVKKMKKKGI VSEKKKKNQP TLSTSDAEKD VEMNNNSSAT DSRFLRDSDA AIM

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [885-1173] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNDKTVAKEH YSSPSSSASQ SNSFSKSDDI ELSKSQAIFH WKNLCYDIPI KNGKRRILDN  60
   61 VDGWVKPGTL TALIGASGAG KTTLLDCLAE RTTMGLITGD VFVDGRPRDQ SFPRSIGYCQ 120
  121 QQDLHLKTAT VRESLRFSAY LRQADDVSIE EKDKYVEEVI EVLEMKLYAD AIVGVPGEGL 180
  181 NVEQRKRLTI GVELAAKPKL LVFLDEPTSG LDSQTAWSTC QLMKKLASRG QAILCTIHQP 240
  241 SALLMQEFDR LLFLQEGGQT VYFGELGKGC KTMINYFEAH GAHKCPPDA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 127.491979
Match: 1l2tA_
Description: MJ0796
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
P-P-bond-hydrolysis-driven transmembrane transporter activity 6.58863529263644 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 6.58067278719409 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 6.57974651657836 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 6.57922174989907 bayes_pls_golite062009
primary active transmembrane transporter activity 6.57807080367604 bayes_pls_golite062009
nucleoside-triphosphatase activity 6.48406410175216 bayes_pls_golite062009
active transmembrane transporter activity 6.48154954364331 bayes_pls_golite062009
pyrophosphatase activity 6.40467109535527 bayes_pls_golite062009
ATPase activity, coupled 6.40151534181487 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 6.38373914253885 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 6.38247436082206 bayes_pls_golite062009
ATPase activity 6.30019941712404 bayes_pls_golite062009
hydrolase activity 4.60957912556603 bayes_pls_golite062009
sterol transporter activity 4.45355165759136 bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism 3.57926427233638 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 3.4837867129694 bayes_pls_golite062009
purine ribonucleotide binding 3.40690615950081 bayes_pls_golite062009
ribonucleotide binding 3.40594996232845 bayes_pls_golite062009
purine nucleotide binding 3.3669118613715 bayes_pls_golite062009
ion transmembrane transporter activity 3.35436118751376 bayes_pls_golite062009
nucleotide binding 3.33248266870364 bayes_pls_golite062009
ATP binding 3.17398570826788 bayes_pls_golite062009
lipid transporter activity 3.14635082108971 bayes_pls_golite062009
adenyl ribonucleotide binding 3.12628113185041 bayes_pls_golite062009
transporter activity 3.10463051760206 bayes_pls_golite062009
cation transmembrane transporter activity 3.08390071341252 bayes_pls_golite062009
adenyl nucleotide binding 3.0710107594224 bayes_pls_golite062009
iron ion transmembrane transporter activity 3.05511942104215 bayes_pls_golite062009
drug transmembrane transporter activity 2.97119034312001 bayes_pls_golite062009
transmembrane transporter activity 2.95886887664984 bayes_pls_golite062009
metal ion transmembrane transporter activity 2.88476360771975 bayes_pls_golite062009
cholesterol transporter activity 2.72457626066894 bayes_pls_golite062009
amine-transporting ATPase activity 2.69529191205818 bayes_pls_golite062009
organic acid transmembrane transporter activity 2.67957846350199 bayes_pls_golite062009
carboxylic acid transmembrane transporter activity 2.67815672695824 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 2.61311581579476 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 2.40292717311506 bayes_pls_golite062009
amine transmembrane transporter activity 2.29486577878686 bayes_pls_golite062009
2.20174656498665 bayes_pls_golite062009
eye pigment precursor transporter activity 2.19742277986318 bayes_pls_golite062009
apolipoprotein A-I receptor activity 2.15656963765495 bayes_pls_golite062009
apolipoprotein receptor activity 2.15656963765495 bayes_pls_golite062009
syntaxin-13 binding 2.15656963765495 bayes_pls_golite062009
apolipoprotein A-I binding 2.15656963765495 bayes_pls_golite062009
anion transmembrane-transporting ATPase activity 2.12727614888121 bayes_pls_golite062009
binding 2.01755875920323 bayes_pls_golite062009
substrate-specific transporter activity 1.91091452720653 bayes_pls_golite062009
inorganic anion transmembrane transporter activity 1.88153949603611 bayes_pls_golite062009
transition metal ion transmembrane transporter activity 1.82177108193332 bayes_pls_golite062009
azole transporter activity 1.75428613304237 bayes_pls_golite062009
fluconazole transporter activity 1.75428613304237 bayes_pls_golite062009
amino acid transmembrane transporter activity 1.59627719545436 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 1.58971273330352 bayes_pls_golite062009
peptide-transporting ATPase activity 1.37783759788533 bayes_pls_golite062009
cation channel activity 1.33585529285301 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions 1.23799860254751 bayes_pls_golite062009
peptide transporter activity 1.19353064661766 bayes_pls_golite062009
potassium channel activity 1.17288958041707 bayes_pls_golite062009
voltage-gated cation channel activity 1.00384984515681 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
nucleic acid binding 0.896078342024449 bayes_pls_golite062009
voltage-gated ion channel activity 0.889208591820696 bayes_pls_golite062009
voltage-gated channel activity 0.871525745291603 bayes_pls_golite062009
0.869999622006359 bayes_pls_golite062009
ion channel activity 0.848261056209476 bayes_pls_golite062009
passive transmembrane transporter activity 0.806331380134838 bayes_pls_golite062009
channel activity 0.806331380134838 bayes_pls_golite062009
substrate-specific channel activity 0.799997700906738 bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity 0.767424210804186 bayes_pls_golite062009
phospholipid transporter activity 0.755445322666929 bayes_pls_golite062009
DNA-dependent ATPase activity 0.70364355116614 bayes_pls_golite062009
gated channel activity 0.650050847753837 bayes_pls_golite062009
branched-chain aliphatic amino acid transmembrane transporter activity 0.442220326523999 bayes_pls_golite062009
anion transmembrane transporter activity 0.43332053110728 bayes_pls_golite062009
DNA binding 0.361518668029935 bayes_pls_golite062009
canalicular bile acid transmembrane transporter activity 0.301752323171649 bayes_pls_golite062009
neutral amino acid transmembrane transporter activity 0.227570438294493 bayes_pls_golite062009
GTPase activity 0.20164416416912 bayes_pls_golite062009
G-protein coupled receptor activity 0.169034229773346 bayes_pls_golite062009
amino acid-transporting ATPase activity 0.147644650870465 bayes_pls_golite062009
motor activity 0.14734538548583 bayes_pls_golite062009
signal transducer activity 0.144122328222529 bayes_pls_golite062009
molecular transducer activity 0.144122328222529 bayes_pls_golite062009
transcription regulator activity 0.133605084599819 bayes_pls_golite062009
protein binding 0.071010918255742 bayes_pls_golite062009
cation-transporting ATPase activity 0.0536898657672154 bayes_pls_golite062009

Predicted Domain #7
Region A:
Residues: [1174-1475] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NPAEWMLEIV GAAPGTHASQ DYFAIWRDSE EYREMQKELD WMERELPKRT EGSSNEEQKE  60
   61 FATSTLYQIK LVSYRLFHQY WRTPFYLWSK FFSTIVSELF IGFTFFKANT SLQGLQNQML 120
  121 AIFMFTVVFN PILQQYLPLF VQQRELYEAR ERPSRTFSWK AFIVSQILVE IPWNLLAGTI 180
  181 AFFVYYYPVG FYRNASYANQ LHERGALFWL FACAFYVYIS SMGVLVISCI EIAENAANLA 240
  241 SLFFIMSLSF CGVLATPNIL PRFWIFMYRV SPLTYLIDAL LSVGLANASV VCSSNELLKI 300
  301 VP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [1476-1564] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSGMTCSEYM EPYMQSTGTG YLLDGSSETE CHFCQFSSTN DYLATVSSSY SRRWMNYGIF  60
   61 SAYIVFDYCA AIFLYWLVRV PKKSKKLKK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #9
Region A:
Residues: [1372-1564] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NQLHERGALF WLFACAFYVY ISSMGVLVIS CIEIAENAAN LASLFFIMSL SFCGVLATPN  60
   61 ILPRFWIFMY RVSPLTYLID ALLSVGLANA SVVCSSNELL KIVPPSGMTC SEYMEPYMQS 120
  121 TGTGYLLDGS SETECHFCQF SSTNDYLATV SSSYSRRWMN YGIFSAYIVF DYCAAIFLYW 180
  181 LVRVPKKSKK LKK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle