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View Structure Prediction Details

Protein: RAS1
Organism: Saccharomyces cerevisiae
Length: 309 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RAS1.

Description E-value Query
Range		 Subject
Range
RAS1_YEAST - Ras-like protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RAS1 PE=1 SV=2
RAS1 - GTPase involved in G-protein signaling in the adenylate cyclase activating pathway, plays a role in ...
 0.0 [1..309] [1..309]
gi|974778 - gi|974778|emb|CAA89049.1| small G protein [Beta vulgaris subsp. vulgaris]
RB2BV_BETVU - Ras-related protein Rab2BV OS=Beta vulgaris GN=RAB2BV PE=2 SV=1
 2.0E-91 [1..211] [1..213]
RIC2_ORYSA - Ras-related protein RIC2 - Oryza sativa (Rice)
RIC2_ORYSJ - Ras-related protein RIC2 OS=Oryza sativa subsp. japonica GN=RIC2 PE=2 SV=2
gi|125555691 - gi|125555691|gb|EAZ01297.1| hypothetical protein OsI_23327 [Oryza sativa Indica Group]
 4.0E-91 [3..212] [7..217]
RAA1F_ARATH - Ras-related protein RABA1f OS=Arabidopsis thaliana GN=RABA1F PE=2 SV=1
 6.0E-91 [3..212] [6..217]
RB11B_TOBAC - Ras-related protein Rab11B OS=Nicotiana tabacum GN=RAB11B PE=2 SV=1
 1.0E-89 [3..211] [7..216]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 1.0E-89 [4..211] [2..201]

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Predicted Domain #1
Region A:
Residues: [1-185] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQGNKSTIRE YKIVVVGGGG VGKSALTIQF IQSYFVDEYD PTIEDSYRKQ VVIDDKVSIL  60
   61 DILDTAGQEE YSAMREQYMR TGEGFLLVYS VTSRNSFDEL LSYYQQIQRV KDSDYIPVVV 120
  121 VGNKLDLENE RQVSYEDGLR LAKQLNAPFL ETSAKQAINV DEAFYSLIRL VRDDGGKYNS 180
  181 MNRQL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 594.68867
Match: 821p__
Description: cH-p21 Ras protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
structural constituent of ribosome 4.14187056198902 bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism 3.57926427233638 bayes_pls_golite062009
structural molecule activity 3.22453402481353 bayes_pls_golite062009
transporter activity 3.10463051760206 bayes_pls_golite062009
transmembrane transporter activity 2.95886887664984 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.95079405147356 bayes_pls_golite062009
pyrophosphatase activity 2.87427509025394 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 2.85499564954033 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.85178667290149 bayes_pls_golite062009
motor activity 2.79327761685782 bayes_pls_golite062009
microtubule motor activity 2.74365461017633 bayes_pls_golite062009
organic acid transmembrane transporter activity 2.67957846350199 bayes_pls_golite062009
carboxylic acid transmembrane transporter activity 2.67815672695824 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
primary active transmembrane transporter activity 2.61775212528604 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 2.61467977505707 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 2.61311581579476 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 2.57552435627908 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 2.57107347424517 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 2.57054427875021 bayes_pls_golite062009
hydrolase activity 2.55157966585974 bayes_pls_golite062009
nucleic acid binding 2.51683451033161 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 2.50934147358924 bayes_pls_golite062009
active transmembrane transporter activity 2.50494515048649 bayes_pls_golite062009
ATPase activity, coupled 2.43862163407966 bayes_pls_golite062009
ATPase activity 2.39535714892224 bayes_pls_golite062009
G-protein coupled receptor activity 2.3505608190884 bayes_pls_golite062009
amine transmembrane transporter activity 2.29486577878686 bayes_pls_golite062009
DNA binding 2.12258000781149 bayes_pls_golite062009
transcription regulator activity 2.09345198747025 bayes_pls_golite062009
RNA helicase activity 2.05761688027604 bayes_pls_golite062009
substrate-specific transporter activity 1.91091452720653 bayes_pls_golite062009
guanyl nucleotide binding 1.89320355239381 bayes_pls_golite062009
guanyl ribonucleotide binding 1.88721318481223 bayes_pls_golite062009
GTP binding 1.87900088157196 bayes_pls_golite062009
purine ribonucleotide binding 1.85943679361938 bayes_pls_golite062009
ribonucleotide binding 1.85937484083653 bayes_pls_golite062009
purine nucleotide binding 1.8521191028835 bayes_pls_golite062009
nucleotide binding 1.84603132945448 bayes_pls_golite062009
kinase activity 1.80889641165674 bayes_pls_golite062009
protein transporter activity 1.71214667007262 bayes_pls_golite062009
GTPase activity 1.6309422514633 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.60386625568858 bayes_pls_golite062009
amino acid transmembrane transporter activity 1.59627719545436 bayes_pls_golite062009
ATP binding 1.5859264197035 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 1.56325751172863 bayes_pls_golite062009
adenyl ribonucleotide binding 1.55520429131224 bayes_pls_golite062009
adenyl nucleotide binding 1.53158018507951 bayes_pls_golite062009
signal recognition particle binding 1.46975774710831 bayes_pls_golite062009
actin binding 1.42666717383185 bayes_pls_golite062009
cytoskeletal protein binding 1.40488517180956 bayes_pls_golite062009
microfilament motor activity 1.33993901826495 bayes_pls_golite062009
transmembrane receptor activity 1.26314334516725 bayes_pls_golite062009
protein binding 1.22129154759482 bayes_pls_golite062009
DNA-dependent ATPase activity 1.2155186842031 bayes_pls_golite062009
receptor activity 1.20313362488821 bayes_pls_golite062009
helicase activity 1.16085745407703 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.14475274823167 bayes_pls_golite062009
signal transducer activity 1.13474466330485 bayes_pls_golite062009
molecular transducer activity 1.13474466330485 bayes_pls_golite062009
protein kinase activity 1.12864835254143 bayes_pls_golite062009
apolipoprotein receptor activity 1.02132483910092 bayes_pls_golite062009
syntaxin-13 binding 1.02132483910092 bayes_pls_golite062009
apolipoprotein A-I binding 1.02132483910092 bayes_pls_golite062009
apolipoprotein A-I receptor activity 1.02132483910092 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
tubulin binding 0.979946830272106 bayes_pls_golite062009
ion transmembrane transporter activity 0.977237423302079 bayes_pls_golite062009
DNA-directed DNA polymerase activity 0.971476020912368 bayes_pls_golite062009
RNA-dependent ATPase activity 0.95986988363392 bayes_pls_golite062009
ATP-dependent RNA helicase activity 0.94128341275411 bayes_pls_golite062009
DNA polymerase activity 0.928091843881235 bayes_pls_golite062009
microtubule binding 0.907162506177187 bayes_pls_golite062009
transcription activator activity 0.889929694023098 bayes_pls_golite062009
transcription factor activity 0.887108427603557 bayes_pls_golite062009
protein methyltransferase activity 0.876296121718575 bayes_pls_golite062009
transferase activity 0.871779313294914 bayes_pls_golite062009
DNA helicase activity 0.72881469450553 bayes_pls_golite062009
protein-DNA loading ATPase activity 0.650964453464311 bayes_pls_golite062009
histone methyltransferase activity 0.63002958837536 bayes_pls_golite062009
cell surface binding 0.618263399939881 bayes_pls_golite062009
ATP-dependent helicase activity 0.59513742813869 bayes_pls_golite062009
purine NTP-dependent helicase activity 0.59513742813869 bayes_pls_golite062009
cation transmembrane transporter activity 0.557919489256916 bayes_pls_golite062009
sequence-specific DNA binding 0.543891899378373 bayes_pls_golite062009
DNA clamp loader activity 0.543512707823441 bayes_pls_golite062009
ribonucleoprotein binding 0.53788302029845 bayes_pls_golite062009
protein transmembrane transporter activity 0.46552249844591 bayes_pls_golite062009
branched-chain aliphatic amino acid transmembrane transporter activity 0.442220326523999 bayes_pls_golite062009
actin filament binding 0.437646833557392 bayes_pls_golite062009
signal sequence binding 0.42240724331108 bayes_pls_golite062009
drug transmembrane transporter activity 0.38711726712063 bayes_pls_golite062009
protein serine/threonine kinase activity 0.345873656782869 bayes_pls_golite062009
peptide binding 0.304703625340488 bayes_pls_golite062009
structure-specific DNA binding 0.249173645231486 bayes_pls_golite062009
ATP-dependent DNA helicase activity 0.22150712609541 bayes_pls_golite062009
amino acid-transporting ATPase activity 0.147644650870465 bayes_pls_golite062009
amine-transporting ATPase activity 0.135455889967401 bayes_pls_golite062009
nucleobase, nucleoside, nucleotide kinase activity 0.12351419478929 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 0.123304946374679 bayes_pls_golite062009
double-stranded DNA binding 0.0781650226500197 bayes_pls_golite062009
metal ion transmembrane transporter activity 0.0775601177068852 bayes_pls_golite062009
RNA binding 0.0693163519626152 bayes_pls_golite062009
P-P-bond-hydrolysis-driven protein transmembrane transporter activity 0.00571427458217011 bayes_pls_golite062009
macromolecule transmembrane transporter activity 0.00571427458217011 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [186-244] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DNTNEIRDSE LTSSATADRE KKNNGSYVLD NSLTNAGTGS SSKSAVNHNG ETTKRTDEK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [245-309] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NYVNQNNNNE GNTKYSSNGN GNRSDISRGN QNNALNSRSK QSAEPQKNSS ANARKESSGG  60
   61 CCIIC

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle