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View Structure Prediction Details

Protein: RAS2
Organism: Saccharomyces cerevisiae
Length: 322 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RAS2.

Description E-value Query
Range		 Subject
Range
RAS2_YEAST - Ras-like protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RAS2 PE=1 SV=4
gi|207341727 - gi|207341727|gb|EDZ69704.1| YNL098Cp-like protein [Saccharomyces cerevisiae AWRI1631]
gi|190409087 - gi|190409087|gb|EDV12352.1| small GTP-binding protein [Saccharomyces cerevisiae RM11-1a]
RAS2 - GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous gr...
gi|151944436 - gi|151944436|gb|EDN62714.1| small GTP-binding protein [Saccharomyces cerevisiae YJM789]
 0.0 [1..322] [1..322]
YPTC6_CHLRE - Ras-related protein YPTC6 OS=Chlamydomonas reinhardtii GN=YPTC6 PE=3 SV=1
 2.0E-90 [4..214] [6..216]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 3.0E-90 [3..211] [1..201]
ARA5_ARATH - Ras-related protein ARA-5 - Arabidopsis thaliana (Mouse-ear cress)
 5.0E-90 [3..211] [56..257]
YPT3_NICPL - Ras-related protein YPT3 OS=Nicotiana plumbaginifolia GN=YPT3 PE=2 SV=1
 2.0E-89 [3..215] [6..218]
gi|1370166 - gi|1370166|emb|CAA98160.1| RAB1C [Lotus japonicus]
 3.0E-89 [3..211] [1..201]
RB11A_PONAB - Ras-related protein Rab-11A OS=Pongo abelii GN=RAB11A PE=2 SV=3
CCDS10212.1_1 - null
ENSCJAT00000014411 - null
RB11A_RABIT - Ras-related protein Rab-11A OS=Oryctolagus cuniculus GN=RAB11A PE=2 SV=3
RB11A_RAT - Ras-related protein Rab-11A OS=Rattus norvegicus GN=Rab11a PE=1 SV=3
RB11A_PONPY - Ras-related protein Rab-11A - Pongo pygmaeus (Orangutan)
RB11A_MOUSE - Ras-related protein Rab-11A OS=Mus musculus GN=Rab11a PE=1 SV=3
RB11A_CANLF - Ras-related protein Rab-11A OS=Canis lupus familiaris GN=RAB11A PE=2 SV=3
ENSMMUG000000080... - null, null
gi|123999492, gi... - gi|61355514|gb|AAX41148.1| RAB11A member RAS oncogene family [synthetic construct], gi|61355506|gb|A...
gi|114657631 - gi|114657631|ref|XP_510490.2| PREDICTED: similar to rab11 [Pan troglodytes]
tr|G3I0B0|G3I0B0... - Ras-related protein Rab-11A OS=Cricetulus griseus GN=I79_016788 PE=3 SV=1
tr|M3WVD0|M3WVD0... - RAB11A, member RAS oncogene family OS=Felis catus GN=RAB11A PE=4 SV=1
gi|76675213|ref|... - PREDICTED: similar to RAB11a, member RAS oncogene family isoform 2 [Bos taurus], Isoform of Q2TA29, ...
RB11A_PIG - Ras-related protein Rab-11A OS=Sus scrofa GN=RAB11A PE=2 SV=3
gi|126277069 - gi|126277069|ref|XP_001367185.1| PREDICTED: similar to rab11 [Monodelphis domestica]
RAB11A - RAB11A, member RAS oncogene family
 3.0E-89 [4..215] [5..215]

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Predicted Domain #1
Region A:
Residues: [1-185] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPLNKSNIRE YKLVVVGGGG VGKSALTIQL TQSHFVDEYD PTIEDSYRKQ VVIDDEVSIL  60
   61 DILDTAGQEE YSAMREQYMR NGEGFLLVYS ITSKSSLDEL MTYYQQILRV KDTDYVPIVV 120
  121 VGNKSDLENE KQVSYQDGLN MAKQMNAPFL ETSAKQAINV EEAFYTLARL VRDEGGKYNK 180
  181 TLTEN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 609.0
Match: 821p__
Description: cH-p21 Ras protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
GTPase activity 4.52394549632777 bayes_pls_golite062009
motor activity 4.04927796049806 bayes_pls_golite062009
microtubule motor activity 3.91769993918004 bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism 3.57926427233638 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 3.4837867129694 bayes_pls_golite062009
ion transmembrane transporter activity 3.35436118751376 bayes_pls_golite062009
transporter activity 3.10463051760206 bayes_pls_golite062009
cation transmembrane transporter activity 3.08390071341252 bayes_pls_golite062009
transmembrane transporter activity 2.95886887664984 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.95079405147356 bayes_pls_golite062009
pyrophosphatase activity 2.87427509025394 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 2.85499564954033 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.85178667290149 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
primary active transmembrane transporter activity 2.61775212528604 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 2.61467977505707 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 2.61311581579476 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 2.57552435627908 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 2.57107347424517 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 2.57054427875021 bayes_pls_golite062009
hydrolase activity 2.55157966585974 bayes_pls_golite062009
microfilament motor activity 2.51786963027655 bayes_pls_golite062009
nucleic acid binding 2.51683451033161 bayes_pls_golite062009
active transmembrane transporter activity 2.50494515048649 bayes_pls_golite062009
ATPase activity, coupled 2.43862163407966 bayes_pls_golite062009
cytoskeletal protein binding 2.4101693596493 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 2.40292717311506 bayes_pls_golite062009
ATPase activity 2.39535714892224 bayes_pls_golite062009
actin binding 2.2973522188675 bayes_pls_golite062009
metal ion transmembrane transporter activity 2.26365379756656 bayes_pls_golite062009
DNA binding 2.12258000781149 bayes_pls_golite062009
transcription regulator activity 2.09345198747025 bayes_pls_golite062009
tubulin binding 1.92557767696163 bayes_pls_golite062009
substrate-specific transporter activity 1.91091452720653 bayes_pls_golite062009
guanyl nucleotide binding 1.89320355239381 bayes_pls_golite062009
guanyl ribonucleotide binding 1.88721318481223 bayes_pls_golite062009
GTP binding 1.87900088157196 bayes_pls_golite062009
purine ribonucleotide binding 1.85943679361938 bayes_pls_golite062009
ribonucleotide binding 1.85937484083653 bayes_pls_golite062009
purine nucleotide binding 1.8521191028835 bayes_pls_golite062009
nucleotide binding 1.84603132945448 bayes_pls_golite062009
microtubule binding 1.84561785126784 bayes_pls_golite062009
kinase activity 1.80889641165674 bayes_pls_golite062009
helicase activity 1.70242731830224 bayes_pls_golite062009
G-protein coupled receptor activity 1.63949223587737 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.60386625568858 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 1.58971273330352 bayes_pls_golite062009
ATP binding 1.5859264197035 bayes_pls_golite062009
adenyl ribonucleotide binding 1.55520429131224 bayes_pls_golite062009
adenyl nucleotide binding 1.53158018507951 bayes_pls_golite062009
structural constituent of ribosome 1.47858140861683 bayes_pls_golite062009
actin filament binding 1.28204719195916 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions 1.23799860254751 bayes_pls_golite062009
protein binding 1.22129154759482 bayes_pls_golite062009
DNA-dependent ATPase activity 1.2155186842031 bayes_pls_golite062009
ATP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
purine NTP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.14475274823167 bayes_pls_golite062009
protein kinase activity 1.12864835254143 bayes_pls_golite062009
nucleotide kinase activity 1.10251779925246 bayes_pls_golite062009
beta-catenin binding 1.03146778136145 bayes_pls_golite062009
apolipoprotein receptor activity 1.02132483910092 bayes_pls_golite062009
syntaxin-13 binding 1.02132483910092 bayes_pls_golite062009
apolipoprotein A-I binding 1.02132483910092 bayes_pls_golite062009
apolipoprotein A-I receptor activity 1.02132483910092 bayes_pls_golite062009
GDP-dissociation inhibitor binding 1.01467127484205 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
cation channel activity 0.997064416395892 bayes_pls_golite062009
GMP binding 0.975301479415235 bayes_pls_golite062009
DNA-directed DNA polymerase activity 0.971476020912368 bayes_pls_golite062009
DNA polymerase activity 0.928091843881235 bayes_pls_golite062009
actin-dependent ATPase activity 0.92105578610354 bayes_pls_golite062009
transcription activator activity 0.889929694023098 bayes_pls_golite062009
transcription factor activity 0.887108427603557 bayes_pls_golite062009
protein methyltransferase activity 0.876296121718575 bayes_pls_golite062009
transferase activity 0.871779313294914 bayes_pls_golite062009
structural molecule activity 0.86514677273731 bayes_pls_golite062009
structural constituent of muscle 0.842950252373832 bayes_pls_golite062009
copper ion transmembrane transporter activity 0.816469301666725 bayes_pls_golite062009
structure-specific DNA binding 0.782430219754236 bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity 0.767424210804186 bayes_pls_golite062009
DNA helicase activity 0.72881469450553 bayes_pls_golite062009
voltage-gated cation channel activity 0.688632087597536 bayes_pls_golite062009
signal transducer activity 0.683309012097319 bayes_pls_golite062009
molecular transducer activity 0.683309012097319 bayes_pls_golite062009
transmembrane receptor activity 0.661834961742057 bayes_pls_golite062009
protein-DNA loading ATPase activity 0.650964453464311 bayes_pls_golite062009
steroid hormone receptor binding 0.647625526012423 bayes_pls_golite062009
calcium channel activity 0.636216614902039 bayes_pls_golite062009
receptor activity 0.633514002718998 bayes_pls_golite062009
histone methyltransferase activity 0.63002958837536 bayes_pls_golite062009
double-stranded DNA binding 0.6071273686445 bayes_pls_golite062009
ATP-dependent DNA helicase activity 0.5886142102548 bayes_pls_golite062009
plus-end-directed microtubule motor activity 0.567883621045161 bayes_pls_golite062009
voltage-gated channel activity 0.562664200036023 bayes_pls_golite062009
voltage-gated ion channel activity 0.559798751382976 bayes_pls_golite062009
sequence-specific DNA binding 0.543891899378373 bayes_pls_golite062009
DNA clamp loader activity 0.543512707823441 bayes_pls_golite062009
protein transporter activity 0.498432226280822 bayes_pls_golite062009
DNA strand annealing activity 0.495691434532349 bayes_pls_golite062009
anion transmembrane transporter activity 0.43332053110728 bayes_pls_golite062009
phosphotransferase activity, phosphate group as acceptor 0.40217318916177 bayes_pls_golite062009
drug transmembrane transporter activity 0.38711726712063 bayes_pls_golite062009
hormone receptor binding 0.351501100511918 bayes_pls_golite062009
protein serine/threonine kinase activity 0.345873656782869 bayes_pls_golite062009
potassium channel activity 0.329290830676079 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.328170855722634 bayes_pls_golite062009
gated channel activity 0.299411774392227 bayes_pls_golite062009
translation regulator activity 0.29096092258568 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.274994961137851 bayes_pls_golite062009
transition metal ion transmembrane transporter activity 0.248918847596573 bayes_pls_golite062009
nuclear hormone receptor binding 0.246160342138071 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.243902356228423 bayes_pls_golite062009
RNA helicase activity 0.18426050934025 bayes_pls_golite062009
ion channel activity 0.154779598791225 bayes_pls_golite062009
RNA-dependent ATPase activity 0.14606996093053 bayes_pls_golite062009
channel activity 0.134817721656507 bayes_pls_golite062009
passive transmembrane transporter activity 0.134817721656507 bayes_pls_golite062009
ATP-dependent RNA helicase activity 0.13050483816765 bayes_pls_golite062009
substrate-specific channel activity 0.126911677161968 bayes_pls_golite062009
nucleobase, nucleoside, nucleotide kinase activity 0.12351419478929 bayes_pls_golite062009
voltage-gated calcium channel activity 0.0789800146503108 bayes_pls_golite062009
cation-transporting ATPase activity 0.0536898657672154 bayes_pls_golite062009
inorganic anion transmembrane transporter activity 0.0122470146764899 bayes_pls_golite062009
structural constituent of cytoskeleton 0.0111338193708552 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [186-322] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DNSKQTSQDT KGSGANSVPR NSGGHRKMSN AANGKNVNSS TTVVNARNAS IESKTGLAGN  60
   61 QATNGKTQTD RTNIDNSTGQ AGQANAQSAN TVNNRVNNNS KAGQVSNAKQ ARKQQAAPGG 120
  121 NTSEASKSGS GGCCIIS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.332 0.306 activation of adenylate cyclase activity a.1.1 Globin-like
View Download 0.332 0.014 intracellular a.1.1 Globin-like
View Download 0.329 N/A N/A a.1.1 Globin-like
View Download 0.294 N/A N/A a.1.1 Globin-like

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle