YRC Public Data Repository - Protein Structure Prediction

Protein:	DRS1
Organism:	Saccharomyces cerevisiae
Length:	752 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DRS1.

Description	E-value	Query Range	Subject Range
DRS1_YEAST - ATP-dependent RNA helicase DRS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DRS1 PE=... DRS1 - Nucleolar DEAD-box protein required for ribosome assembly and function, including synthesis of 60S r...	0.0	[1..752]	[1..752]
DDX4 - DEAD (Asp-Glu-Ala-Asp) box polypeptide 4	0.0	[9..635]	[40..695]
DDX3_XENLA - Putative ATP-dependent RNA helicase an3 OS=Xenopus laevis GN=an3 PE=2 SV=1	0.0	[36..619]	[34..620]
DDX4_RAT - Probable ATP-dependent RNA helicase DDX4 OS=Rattus norvegicus GN=Ddx4 PE=1 SV=1 gi\|806464 - gi\|806464\|gb\|AAB33364.1\| vasa-like gene protein; RVLG protein [Rattus sp.]	0.0	[9..613]	[42..658]
DDX3X_MOUSE - ATP-dependent RNA helicase DDX3X OS=Mus musculus GN=Ddx3x PE=1 SV=3	0.0	[61..619]	[19..579]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[52..635]	[1..606]

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Predicted Domain #1

Region A:
Residues: [1-68]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVVGTKKYSN LDFVPTISDS EDDVPILDSS DDEKVEAKKT TKKRKGKNNK KKVSEGDNLD  60
   61 EDVHEDLD

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	9.57
Match:	1l8mA
Description:	No description for 1l8mA was found.

Predicted Domain #2

Region A:
Residues: [69-147]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AGFKFDLDAD DTTSNFQGWN FLAEGESNKD DAEAFVKKDV DLDKIIRRKG GLVKMAHIDS  60
   61 KQEEETEKEK VEKENDSDD

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	9.57
Match:	1l8mA
Description:	No description for 1l8mA was found.

Predicted Domain #3

Region A:
Residues: [148-231]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EELAMDGFGM GAPMNNGDEN QSEEEEEEEE KEEEEEEEEE QEEMTLEKGG KDDEIDEEDD  60
   61 SEEAKADFYA PETEGDEAKK QMYE

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	9.57
Match:	1l8mA
Description:	No description for 1l8mA was found.

Predicted functions:

Term	Confidence	Notes
translation initiation factor activity	7.79457008386475	bayes_pls_golite062009
translation factor activity, nucleic acid binding	4.98637553020315	bayes_pls_golite062009
translation regulator activity	4.94658029227343	bayes_pls_golite062009
	4.704140727858	bayes_pls_golite062009
structural constituent of ribosome	4.56509805974548	bayes_pls_golite062009
structural molecule activity	3.58406348799895	bayes_pls_golite062009
nucleoside-triphosphatase activity	2.95079405147356	bayes_pls_golite062009
pyrophosphatase activity	2.87427509025394	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	2.85499564954033	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	2.85178667290149	bayes_pls_golite062009
motor activity	2.79327761685782	bayes_pls_golite062009
microtubule motor activity	2.74365461017633	bayes_pls_golite062009
binding	2.64537357529343	bayes_pls_golite062009
transporter activity	2.58140740499725	bayes_pls_golite062009
hydrolase activity	2.55157966585974	bayes_pls_golite062009
nucleic acid binding	2.51683451033161	bayes_pls_golite062009
transmembrane transporter activity	2.39695871109024	bayes_pls_golite062009
ATPase activity	2.39535714892224	bayes_pls_golite062009
RNA binding	2.29590582680214	bayes_pls_golite062009
ATPase activity, coupled	2.18396165590908	bayes_pls_golite062009
RNA cap binding	2.17871969124431	bayes_pls_golite062009
DNA binding	1.94055378599526	bayes_pls_golite062009
transcription regulator activity	1.83584389083042	bayes_pls_golite062009
helicase activity	1.70242731830224	bayes_pls_golite062009
protein-DNA loading ATPase activity	1.54436515966471	bayes_pls_golite062009
DNA clamp loader activity	1.51134988628578	bayes_pls_golite062009
RNA helicase activity	1.42791449104435	bayes_pls_golite062009
cytoskeletal protein binding	1.40488517180956	bayes_pls_golite062009
RNA-dependent ATPase activity	1.39335733374328	bayes_pls_golite062009
ATP-dependent RNA helicase activity	1.36724390116598	bayes_pls_golite062009
substrate-specific transporter activity	1.29730375126024	bayes_pls_golite062009
DNA-dependent ATPase activity	1.2155186842031	bayes_pls_golite062009
purine NTP-dependent helicase activity	1.19311444180077	bayes_pls_golite062009
ATP-dependent helicase activity	1.19311444180077	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
tubulin binding	0.979946830272106	bayes_pls_golite062009
DNA-directed DNA polymerase activity	0.971476020912368	bayes_pls_golite062009
transcription factor activity	0.959949409533517	bayes_pls_golite062009
purine nucleotide binding	0.929901285538132	bayes_pls_golite062009
DNA polymerase activity	0.928091843881235	bayes_pls_golite062009
nucleotide binding	0.922442819194247	bayes_pls_golite062009
purine ribonucleotide binding	0.920987930180051	bayes_pls_golite062009
ribonucleotide binding	0.920926158369519	bayes_pls_golite062009
microtubule binding	0.907162506177187	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.906554174337376	bayes_pls_golite062009
actin binding	0.883285269827407	bayes_pls_golite062009
structure-specific DNA binding	0.782430219754236	bayes_pls_golite062009
mRNA binding	0.76699944561918	bayes_pls_golite062009
DNA helicase activity	0.72881469450553	bayes_pls_golite062009
ribonuclease activity	0.712344060953362	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	0.652333406433794	bayes_pls_golite062009
double-stranded DNA binding	0.6071273686445	bayes_pls_golite062009
transcription repressor activity	0.607045223341107	bayes_pls_golite062009
ATP-dependent DNA helicase activity	0.5886142102548	bayes_pls_golite062009
GTPase activity	0.437665353870877	bayes_pls_golite062009
active transmembrane transporter activity	0.434775387083003	bayes_pls_golite062009
snRNA binding	0.418985924846052	bayes_pls_golite062009
ATP binding	0.41092997612902	bayes_pls_golite062009
adenyl ribonucleotide binding	0.385813421701492	bayes_pls_golite062009
adenyl nucleotide binding	0.377870145186619	bayes_pls_golite062009
ion transmembrane transporter activity	0.355466224802969	bayes_pls_golite062009
guanyl nucleotide binding	0.296406132096546	bayes_pls_golite062009
GTP binding	0.295705904888768	bayes_pls_golite062009
primary active transmembrane transporter activity	0.294474570607914	bayes_pls_golite062009
guanyl ribonucleotide binding	0.29028316917561	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	0.282352478532746	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	0.220608508617331	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	0.219533217661421	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	0.219157471322311	bayes_pls_golite062009
protein binding	0.170837278876362	bayes_pls_golite062009
microfilament motor activity	0.10236059675512	bayes_pls_golite062009
protein transporter activity	0.0397092337273124	bayes_pls_golite062009
cation transmembrane transporter activity	0.0254369227200564	bayes_pls_golite062009
signal sequence binding	6.53725193420218E-4	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [232-444]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NFNSLSLSRP VLKGLASLGY VKPSPIQSAT IPIALLGKDI IAGAVTGSGK TAAFMIPIIE  60
   61 RLLYKPAKIA STRVIVLLPT RELAIQVADV GKQIARFVSG ITFGLAVGGL NLRQQEQMLK 120
  121 SRPDIVIATP GRFIDHIRNS ASFNVDSVEI LVMDEADRML EEGFQDELNE IMGLLPSNRQ 180
  181 NLLFSATMNS KIKSLVSLSL KKPVRIMIDP PKK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	572.228787
Match:	1hv8A_
Description:	Putative DEAD box RNA helicase
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [445-598]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AATKLTQEFV RIRKRDHLKP ALLFNLIRKL DPTGQKRIVV FVARKETAHR LRIIMGLLGM  60
   61 SVGELHGSLT QEQRLDSVNK FKNLEVPVLI CTDLASRGLD IPKIEVVINY DMPKSYEIYL 120
  121 HRVGRTARAG REGRSVTFVG ESSQDRSIVR AAIK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	572.228787
Match:	1hv8A_
Description:	Putative DEAD box RNA helicase
Matching Structure (courtesy of the PDB):

Predicted Domain #6

Region A:
Residues: [599-752]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SVEENKSLTQ GKALGRNVDW VQIEETNKLV ESMNDTIEDI LVEEKEEKEI LRAEMQLRKG  60
   61 ENMLKHKKEI QARPRRTWFQ SESDKKNSKV LGALSRNKKV TNSKKRKREE AKADGNGARS 120
  121 YRKTKTDRIA DQERTFKKQK STNSNKKKGF KSRR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	12.0
Match:	1d2mA_
Description:	Nucleotide excision repair enzyme UvrB
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: