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View Structure Prediction Details

Protein: HSE1
Organism: Saccharomyces cerevisiae
Length: 452 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HSE1.

Description E-value Query
Range
Subject
Range
HSE1_YEAST - Class E vacuolar protein-sorting machinery protein HSE1 OS=Saccharomyces cerevisiae (strain ATCC 204...
HSE1 - Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane protein...
9.0E-89 [1..452] [1..452]
gi|123997931, gi... - gi|123997931|gb|ABM86567.1| signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 [synth...
STAM2 - signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
1.0E-72 [4..440] [5..460]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
3.0E-70 [4..440] [5..460]
STAM2_MOUSE - Signal transducing adapter molecule 2 OS=Mus musculus GN=Stam2 PE=1 SV=1
2.0E-69 [4..439] [5..457]
STAM2_CHICK - Signal transducing adapter molecule 2 OS=Gallus gallus GN=STAM2 PE=1 SV=1
3.0E-64 [2..420] [3..424]
hse1 - STAM like protein Hse1
HSE1_SCHPO - Class E vacuolar protein-sorting machinery protein hse1 OS=Schizosaccharomyces pombe (strain 972 / A...
4.0E-56 [5..374] [6..367]
Stam-PA - The gene Signal transducing adaptor molecule is referred to in FlyBase by the symbol Dmel\Stam (CG65...
2.0E-51 [5..440] [7..499]

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Predicted Domain #1
Region A:
Residues: [1-78]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSSAIKIRN ALLKATDPKL RSDNWQYILD VCDLVKEDPE DNGQEVMSLI EKRLEQQDAN  60
   61 VILRTLSLTV SLAENCGS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 132.594777
Match: 1elkA_
Description: Tom1 protein
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [79-146]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RLRQEISSKN FTSLLYALIE SHSVHITLKK AVTDVVKQLS DSFKDDPSLR AMGDLYDKIK  60
   61 RKAPYLVQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 132.594777
Match: 1elkA_
Description: Tom1 protein
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [147-207]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PNVPEKHNMS TQADNSDDEE LQKALKMSLF EYEKQKKLQE QEKESAEVLP QQQQQHQQQN  60
   61 Q

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
binding 2.47621789723131 bayes_pls_golite062009
protein binding 2.10925438883926 bayes_pls_golite062009
cytoskeletal protein binding 1.29637592432055 bayes_pls_golite062009
ubiquitin-protein ligase activity 1.02097165614658 bayes_pls_golite062009
small conjugating protein ligase activity 0.938262449967509 bayes_pls_golite062009
transporter activity 0.781252315942763 bayes_pls_golite062009
hydrolase activity 0.539213162060111 bayes_pls_golite062009
transmembrane transporter activity 0.523669943250984 bayes_pls_golite062009
actin binding 0.4786890657602 bayes_pls_golite062009
nucleic acid binding 0.476094076158571 bayes_pls_golite062009
structural molecule activity 0.236653863910566 bayes_pls_golite062009
substrate-specific transporter activity 0.207376833349132 bayes_pls_golite062009
transcription regulator activity 0.151103447043301 bayes_pls_golite062009
DNA binding 0.143439914163001 bayes_pls_golite062009
acid-amino acid ligase activity 0.125965304296204 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [208-303]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 APAHKIPAQT VVRRVRALYD LTTNEPDELS FRKGDVITVL EQVYRDWWKG ALRGNMGIFP  60
   61 LNYVTPIVEP SKEEIEKEKN KEAIVFSQKT TIDQLH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 137.94696
Match: 1griA_
Description: Growth factor receptor-bound protein 2 (GRB2), N- and C-terminal domains; Growth factor receptor-bound protein 2 (GRB2)
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [304-452]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSLNAASKTG NSNEVLQDPH IGDMYGSVTP LRPQVTRMLG KYAKEKEDML SLRQVLANAE  60
   61 RSYNQLMDRA ANAHISPPVP GPALYAGMTH ANNTPVMPPQ RQSYQSNEYS PYPSNLPIQH 120
  121 PTNSANNTPQ YGYDLGYSVV SQPPPGYEQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 137.94696
Match: 1griA_
Description: Growth factor receptor-bound protein 2 (GRB2), N- and C-terminal domains; Growth factor receptor-bound protein 2 (GRB2)
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle