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View Structure Prediction Details

Protein: FAA2
Organism: Saccharomyces cerevisiae
Length: 744 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FAA2.

Description E-value Query
Range
Subject
Range
FAA2 - Medium chain fatty acyl-CoA synthetase, activates imported fatty acids; accepts a wide range of fatt...
gi|151944723 - gi|151944723|gb|EDN62982.1| long chain fatty acyl-CoA synthetase [Saccharomyces cerevisiae YJM789]
LCF2_YEAST - Long-chain-fatty-acid--CoA ligase 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FAA2...
0.0 [1..744] [1..744]
ACSL1_MOUSE - Long-chain-fatty-acid--CoA ligase 1 OS=Mus musculus GN=Acsl1 PE=1 SV=2
0.0 [34..736] [36..697]
ACSL1_CAVPO - Long-chain-fatty-acid--CoA ligase 1 OS=Cavia porcellus GN=ACSL1 PE=2 SV=1
0.0 [34..736] [36..696]
gi|10957124 - gi|10957124|gb|AAG10398.2|AF190741_1 long-chain fatty acid CoA ligase [Callithrix jacchus]
0.0 [34..736] [36..696]
ACSL6 - acyl-CoA synthetase long-chain family member 6
0.0 [20..734] [26..694]
ACSL1_RAT - Long-chain-fatty-acid--CoA ligase 1 OS=Rattus norvegicus GN=Acsl1 PE=1 SV=1
0.0 [34..736] [36..697]

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Predicted Domain #1
Region A:
Residues: [1-77]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAPDYALTD LIESDPRFES LKTRLAGYTK GSDEYIEELY SQLPLTSYPR YKTFLKKQAV  60
   61 AISNPDNEAG FSSIYRS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.855 0.042 N-terminal protein myristoylation a.156.1 S13-like H2TH domain

Predicted functions:

Term Confidence Notes
fatty acid ligase activity 4.83067429373059 bayes_pls_golite062009
long-chain fatty acid-CoA ligase activity 4.72692389032116 bayes_pls_golite062009
ligase activity, forming carbon-sulfur bonds 3.91760861837127 bayes_pls_golite062009
acid-thiol ligase activity 3.07782226172454 bayes_pls_golite062009
CoA-ligase activity 2.9342873477171 bayes_pls_golite062009
lipid transporter activity 2.59608399999188 bayes_pls_golite062009
fatty acid transporter activity 2.59273384982209 bayes_pls_golite062009
ligase activity 2.49556073715112 bayes_pls_golite062009
acetate-CoA ligase activity 2.48713831233526 bayes_pls_golite062009
luciferin monooxygenase activity 2.37933768142137 bayes_pls_golite062009
catalytic activity 1.83545185797733 bayes_pls_golite062009
binding 1.5312519256537 bayes_pls_golite062009
transcription regulator activity 1.51984692702316 bayes_pls_golite062009
transporter activity 1.29780964436121 bayes_pls_golite062009
branched-chain aliphatic amino acid transmembrane transporter activity 1.18574343794772 bayes_pls_golite062009
organic acid transmembrane transporter activity 1.12905679329698 bayes_pls_golite062009
carboxylic acid transmembrane transporter activity 1.11961482903654 bayes_pls_golite062009
transmembrane transporter activity 1.07143339827205 bayes_pls_golite062009
substrate-specific transporter activity 1.03753946113449 bayes_pls_golite062009
long-chain fatty acid transporter activity 0.914069798020245 bayes_pls_golite062009
hydrolase activity 0.793506623954019 bayes_pls_golite062009
amine transmembrane transporter activity 0.75860693537743 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.54797726647835 bayes_pls_golite062009
adenyl ribonucleotide binding 0.340243634970102 bayes_pls_golite062009
adenyl nucleotide binding 0.320997446710099 bayes_pls_golite062009
active transmembrane transporter activity 0.251681382273558 bayes_pls_golite062009
primary active transmembrane transporter activity 0.225448500718996 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 0.216579620878492 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0.177812048124158 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 0.174283007890308 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 0.173963339749644 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.149232835558857 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0401881910649647 bayes_pls_golite062009
pyrophosphatase activity 0.0047964784091391 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [78-92]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SLSSENLVSC VDKNL

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [119-131]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KATGTWEETF RFE

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [297-590]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ISFTSGTTGL PKGVEMSHRN IASGIAFAFS TFRIPPDKRN QQLYDMCFLP LAHIFERMVI  60
   61 AYDLAIGFGI GFLHKPDPTV LVEDLKILKP YAVALVPRIL TRFEAGIKNA LDKSTVQRNV 120
  121 ANTILDSKSA RFTARGGPDK SIMNFLVYHR VLIDKIRDSL GLSNNSFIIT GSAPISKDTL 180
  181 LFLRSALDIG IRQGYGLTET FAGVCLSEPF EKDVGSCGAI GISAECRLKS VPEMGYHADK 240
  241 DLKGELQIRG PQVFERYFKN PNETSKAVDQ DGWFSTGDVA FIDGKGRISV IDRV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 348.54902
Match: 1ba3__
Description: Luciferase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [93-118]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RTAYDHFMFS ARRWPQRDCL GSRPID

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [132-296]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SYSTVSKRCH NIGSGILSLV NTKRKRPLEA NDFVVAILSH NNPEWILTDL ACQAYSLTNT  60
   61 ALYETLGPNT SEYILNLTEA PILIFAKSNM YHVLKMVPDM KFVNTLVCMD ELTHDELRML 120
  121 NESLLPVKCN SLNEKITFFS LEQVEQVGCF NKIPAIPPTP DSLYT

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [591-744]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KNFFKLAHGE YIAPEKIENI YLSSCPYITQ IFVFGDPLKT FLVGIVGVDV DAAQPILAAK  60
   61 HPEVKTWTKE VLVENLNRNK KLRKEFLNKI NKCTDGLQGF EKLHNIKVGL EPLTLEDDVV 120
  121 TPTFKIKRAK ASKFFKDTLD QLYAEGSLVK TEKL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 348.54902
Match: 1ba3__
Description: Luciferase
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle