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Catalysis of the ligation of a fatty acid to an acceptor, coupled to the hydrolysis of ATP. Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]. Catalysis of the reaction: ATP + a very-long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; very-long-chain fatty acids have chain lengths of greater than C18. Catalysis of the reaction: ATP + a medium-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; medium-chain fatty acids have chain lengths of C8-12. Catalysis of the reaction: ATP + a short-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; short-chain fatty acids have chain lengths of less than 8 carbons. Catalysis of the ligation of two substances via a carbon-sulfur bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; long-chain fatty acids have chain lengths of C12-18.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: fatty acid ligase activity
Acc: GO:0015645
Aspect: Molecular Function
Desc: Catalysis of the ligation of a fatty acid to an acceptor, coupled to the hydrolysis of ATP.
Synonyms:
  • acyl coenzyme A synthetase activity
  • fatty acyl-coenzyme A synthetase activity
  • acyl-coenzyme A ligase activity
  • fatty-acid ligase activity
  • acid:CoA ligase (AMP-forming) activity
  • fatty acid CoA ligase activity
Proteins in PDR annotated with:
   This term: 2 [Search]
   Term or descendants: 75 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0015645 - fatty acid ligase activity (interactive image map)

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