YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: GUK1
Organism: Saccharomyces cerevisiae
Length: 187 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GUK1.

Description E-value Query
Range		 Subject
Range
GUK1 - Guanylate kinase, converts GMP to GDP; required for growth and mannose outer chain elongation of cel...
gi|151942419 - gi|151942419|gb|EDN60775.1| guanylate kinase [Saccharomyces cerevisiae YJM789]
KGUA_YEAST - Guanylate kinase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GUK1 PE=1 SV=2
gi|190404621 - gi|190404621|gb|EDV07888.1| guanylate kinase [Saccharomyces cerevisiae RM11-1a]
gi|207346263 - gi|207346263|gb|EDZ72811.1| YDR454Cp-like protein [Saccharomyces cerevisiae AWRI1631]
 1.0E-65 [1..187] [1..187]
gi|51858957 - gb|AAH82189.1| MGC98686 protein [Xenopus laevis]
KGUA_MOUSE - Guanylate kinase OS=Mus musculus GN=Guk1 PE=1 SV=2
 3.0E-64 [3..186] [5..188]
gi|10047455 - gi|10047455|gb|AAG12251.1|AF205130_1 guanylate kinase [Nicotiana tabacum]
 2.0E-62 [1..183] [29..211]
gi|10047457 - gi|10047457|gb|AAG12252.1|AF205131_1 guanylate kinase [Lilium longiflorum]
 1.0E-61 [4..183] [138..317]
GUK1 - guanylate kinase 1
 5.0E-61 [3..186] [5..188]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 2.0E-60 [3..183] [139..319]
GMK2_ARATH - Guanylate kinase 2 OS=Arabidopsis thaliana GN=GK-2 PE=2 SV=1
 2.0E-60 [3..183] [138..318]

Back

Predicted Domain #1
Region A:
Residues: [1-33] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRPIVISGP SGTGKSTLLK KLFAEYPDSF GFS

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [86-187] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VKQVSKSGKT CILDIDMQGV KSVKAIPELN ARFLFIAPPS VEDLKKRLEG RGTETEESIN  60
   61 KRLSAAQAEL AYAETGAHDK VIVNDDLDKA YKELKDFIFA EK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1046.156545
Match: 1ex6A_
Description: Guanylate kinase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
hydrogen ion transporting ATP synthase activity, rotational mechanism 4.94368959158184 bayes_pls_golite062009
GTPase activity 4.06265232661098 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 4.00431985024242 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 3.88411242531695 bayes_pls_golite062009
nucleobase, nucleoside, nucleotide kinase activity 3.66392587433723 bayes_pls_golite062009
transporter activity 3.10463051760206 bayes_pls_golite062009
transmembrane transporter activity 2.95886887664984 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.95079405147356 bayes_pls_golite062009
pyrophosphatase activity 2.87427509025394 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 2.85499564954033 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.85178667290149 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
primary active transmembrane transporter activity 2.61775212528604 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 2.61467977505707 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 2.57552435627908 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 2.57107347424517 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 2.57054427875021 bayes_pls_golite062009
active transmembrane transporter activity 2.50494515048649 bayes_pls_golite062009
ATPase activity, coupled 2.43862163407966 bayes_pls_golite062009
motor activity 2.40267948113603 bayes_pls_golite062009
ATPase activity 2.39535714892224 bayes_pls_golite062009
nucleotide kinase activity 2.24094813695083 bayes_pls_golite062009
glutamate receptor binding 2.18149167417819 bayes_pls_golite062009
phosphotransferase activity, phosphate group as acceptor 1.96697952975573 bayes_pls_golite062009
substrate-specific transporter activity 1.91091452720653 bayes_pls_golite062009
microtubule motor activity 1.77441050776692 bayes_pls_golite062009
hydrolase activity 1.57549510726226 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 1.56325751172863 bayes_pls_golite062009
cytoskeletal protein binding 1.50574672650697 bayes_pls_golite062009
nucleic acid binding 1.08697924060619 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
guanylate kinase activity 0.98934362137863 bayes_pls_golite062009
ion transmembrane transporter activity 0.977237423302079 bayes_pls_golite062009
signal transducer activity 0.952448314982579 bayes_pls_golite062009
molecular transducer activity 0.952448314982579 bayes_pls_golite062009
purine nucleotide binding 0.929901285538132 bayes_pls_golite062009
nucleotide binding 0.922442819194247 bayes_pls_golite062009
purine ribonucleotide binding 0.920987930180051 bayes_pls_golite062009
ribonucleotide binding 0.920926158369519 bayes_pls_golite062009
peptide-transporting ATPase activity 0.911425383309011 bayes_pls_golite062009
actin binding 0.875514430441177 bayes_pls_golite062009
peptide transporter activity 0.73541731084591 bayes_pls_golite062009
DNA binding 0.702147676354075 bayes_pls_golite062009
cation transmembrane transporter activity 0.557919489256916 bayes_pls_golite062009
anion transmembrane-transporting ATPase activity 0.48775834126327 bayes_pls_golite062009
adenylate kinase activity 0.447752711852745 bayes_pls_golite062009
microfilament motor activity 0.415173945174069 bayes_pls_golite062009
ATP binding 0.41092997612902 bayes_pls_golite062009
adenyl ribonucleotide binding 0.385813421701492 bayes_pls_golite062009
adenyl nucleotide binding 0.377870145186619 bayes_pls_golite062009
transcription regulator activity 0.312171320541728 bayes_pls_golite062009
receptor activity 0.277332279568238 bayes_pls_golite062009
tubulin binding 0.264882086048416 bayes_pls_golite062009
inorganic anion transmembrane transporter activity 0.25714006331445 bayes_pls_golite062009
transmembrane receptor activity 0.243026482777117 bayes_pls_golite062009
proton-transporting ATPase activity, rotational mechanism 0.20818362273204 bayes_pls_golite062009
protein binding 0.170837278876362 bayes_pls_golite062009
microtubule binding 0.156470772916507 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 0.123304946374679 bayes_pls_golite062009
metal ion transmembrane transporter activity 0.0775601177068852 bayes_pls_golite062009
helicase activity 0.0775311459068899 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [34-85] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VSSTTRTPRA GEVNGKDYNF VSVDEFKSMI KNNEFIEWAQ FSGNYYGSTV AS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1046.156545
Match: 1ex6A_
Description: Guanylate kinase
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle