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View Structure Prediction Details

Protein: SUP35
Organism: Saccharomyces cerevisiae
Length: 685 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SUP35.

Description E-value Query
Range		 Subject
Range
gi|13278382 - gi|13278382|gb|AAH04005.1| Eukaryotic translation elongation factor 1 alpha 1 [Mus musculus]
 0.0 [254..685] [1..443]
gi|169409549 - gi|169409549|gb|ACA57895.1| eukaryotic translation elongation factor 1 alpha 1 (predicted) [Calliceb...
EF1A1_PANTR - Elongation factor 1-alpha 1 OS=Pan troglodytes GN=EEF1A1 PE=2 SV=1
gi|163781003 - gi|163781003|gb|ABY40784.1| eukaryotic translation elongation factor 1 alpha 1 (predicted) [Papio an...
gi|67970565 - gi|67970565|dbj|BAE01625.1| unnamed protein product [Macaca fascicularis]
EF1A1_PONAB - Elongation factor 1-alpha 1 OS=Pongo abelii GN=EEF1A1 PE=2 SV=2
EEF1A1 - eukaryotic translation elongation factor 1 alpha 1
gi|60819043, gi|... - gi|61363070|gb|AAX42329.1| eukaryotic translation elongation factor 1 alpha 1 [synthetic construct],...
gi|73973292 - gi|73973292|ref|XP_532203.2| PREDICTED: similar to eukaryotic translation elongation factor 1 alpha ...
gi|229368700 - gi|229368700|gb|ACQ62985.1| eukaryotic translation elongation factor 1 alpha 1 (predicted) [Dasypus ...
tr|F6UME7|F6UME7... - Elongation factor 1-alpha OS=Equus caballus OX=9796 GN=EEF1A1 PE=3 SV=1
gi|56342332|dbj|... - eukaryotic translation elongation factor 1 alpha 1 [Pan troglodytes]
EF1A1_BOVIN - Elongation factor 1-alpha 1 OS=Bos taurus GN=EEF1A1 PE=1 SV=1
EF1A1_PONPY - Elongation factor 1-alpha 1 - Pongo pygmaeus (Orangutan)
EF1A1_RABIT - Elongation factor 1-alpha 1 OS=Oryctolagus cuniculus GN=EEF1A1 PE=1 SV=1
gi|109071708, gi... - gi|109071710|ref|XP_001112777.1| PREDICTED: similar to eukaryotic translation elongation factor 1 al...
EF1A1_FELCA - Elongation factor 1-alpha 1 OS=Felis catus GN=EEF1A1 PE=2 SV=1
gi|223019597, gi... - gi|223019599|emb|CAX36487.1| eukaryotic translation elongation factor 1 alpha 1 [Sus scrofa], gi|223...
ENSCJAT00000019570 - null
 0.0 [254..685] [1..443]
gi|15805031, gi|... - gi|15805031|ref|NP_284925.1| eukaryotic translation elongation factor 1 alpha 2 [Rattus norvegicus],...
 0.0 [254..685] [1..443]
EF1A_CHICK - Elongation factor 1-alpha 1 OS=Gallus gallus GN=EEF1A PE=2 SV=1
 0.0 [254..685] [1..443]
EF1A0_XENLA - Elongation factor 1-alpha, somatic form OS=Xenopus laevis GN=eef1as PE=2 SV=1
 0.0 [254..685] [1..443]
gi|19567958, gi|... - gi|19567966|gb|AAK26180.1| prion protein [Saccharomyces cerevisiae], gi|19567958|gb|AAK26176.1| prio...
gi|207346638 - gi|207346638|gb|EDZ73078.1| YDR172Wp-like protein [Saccharomyces cerevisiae AWRI1631]
gi|190404873 - gi|190404873|gb|EDV08140.1| eukaryotic peptide chain release factor GTP-binding subunit [Saccharomyc...
 0.0 [1..685] [1..685]

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Predicted Domain #1
Region A:
Residues: [1-254] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDSNQGNNQ QNYQQYSQNG NQQQGNNRYQ GYQAYNAQAQ PAGGYYQNYQ GYSGYQQGGY  60
   61 QQYNPDAGYQ QQYNPQGGYQ QYNPQGGYQQ QFNPQGGRGN YKNFNYNNNL QGYQAGFQPQ 120
  121 SQGMSLNDFQ KQQKQAAPKP KKTLKLVSSS GIKLANATKK VGTKPAESDK KEEEKSAETK 180
  181 EPTKEPTKVE EPVKKEEKPV QTEEKTEEKS ELPKVEDLKI SESTHNTNNA NVTSADALIK 240
  241 EQEEEVDDEV VNDM

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 13.27
Match: 1ldvA
Description: No description for 1ldvA was found.

Predicted Domain #2
Region A:
Residues: [255-482] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FGGKDHVSLI FMGHVDAGKS TMGGNLLYLT GSVDKRTIEK YEREAKDAGR QGWYLSWVMD  60
   61 TNKEERNDGK TIEVGKAYFE TEKRRYTILD APGHKMYVSE MIGGASQADV GVLVISARKG 120
  121 EYETGFERGG QTREHALLAK TQGVNKMVVV VNKMDDPTVN WSKERYDQCV SNVSNFLRAI 180
  181 GYNIKTDVVF MPVSGYSGAN LKDHVDPKEC PWYTGPTLLE YLDTMNHV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1862.218487
Match: 1jnyA_
Description: Elongation factor eEF-1alpha, domain 2; Elongation factor eEF-1alpha, C-terminal domain; Elongation factor eEF-1alpha, N-terminal (G) domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [483-576] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DRHINAPFML PIAAKMKDLG TIVEGKIESG HIKKGQSTLL MPNKTAVEIQ NIYNETENEV  60
   61 DMAMCGEQVK LRIKGVEEED ISPGFVLTSP KNPI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1862.218487
Match: 1jnyA_
Description: Elongation factor eEF-1alpha, domain 2; Elongation factor eEF-1alpha, C-terminal domain; Elongation factor eEF-1alpha, N-terminal (G) domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
translation elongation factor activity 8.90683166637832 bayes_pls_golite062009
translation factor activity, nucleic acid binding 4.8378725567094 bayes_pls_golite062009
translation regulator activity 4.79814772079421 bayes_pls_golite062009
structural constituent of ribosome 4.56509805974548 bayes_pls_golite062009
structural molecule activity 3.58406348799895 bayes_pls_golite062009
transporter activity 3.10463051760206 bayes_pls_golite062009
transmembrane transporter activity 2.95886887664984 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.95079405147356 bayes_pls_golite062009
pyrophosphatase activity 2.87427509025394 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 2.85499564954033 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.85178667290149 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
hydrolase activity 2.55157966585974 bayes_pls_golite062009
active transmembrane transporter activity 2.50494515048649 bayes_pls_golite062009
translation release factor activity 2.49148102494524 bayes_pls_golite062009
translation termination factor activity 2.46464632547226 bayes_pls_golite062009
primary active transmembrane transporter activity 2.39629638016861 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 2.39600931083427 bayes_pls_golite062009
ATPase activity 2.39535714892224 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 2.36051733655256 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 2.35906629925754 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 2.35679406876731 bayes_pls_golite062009
RNA binding 2.29590582680214 bayes_pls_golite062009
ATPase activity, coupled 2.24901251684901 bayes_pls_golite062009
actin filament binding 2.1683792904715 bayes_pls_golite062009
2.15810909411803 bayes_pls_golite062009
motor activity 2.11140484670646 bayes_pls_golite062009
substrate-specific transporter activity 1.65609907941094 bayes_pls_golite062009
nucleic acid binding 1.49633029954726 bayes_pls_golite062009
actin binding 1.42666717383185 bayes_pls_golite062009
cytoskeletal protein binding 1.40488517180956 bayes_pls_golite062009
microtubule motor activity 1.35938517416356 bayes_pls_golite062009
microfilament motor activity 1.33993901826495 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 1.3182108176243 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
transcription regulator activity 0.989226939888218 bayes_pls_golite062009
ATP binding 0.98146619596929 bayes_pls_golite062009
DNA binding 0.967303417236485 bayes_pls_golite062009
adenyl ribonucleotide binding 0.949788783884952 bayes_pls_golite062009
adenyl nucleotide binding 0.931486373329219 bayes_pls_golite062009
purine nucleotide binding 0.929901285538132 bayes_pls_golite062009
nucleotide binding 0.922442819194247 bayes_pls_golite062009
purine ribonucleotide binding 0.920987930180051 bayes_pls_golite062009
ribonucleotide binding 0.920926158369519 bayes_pls_golite062009
protein methyltransferase activity 0.876296121718575 bayes_pls_golite062009
mRNA binding 0.76699944561918 bayes_pls_golite062009
ion transmembrane transporter activity 0.704934361725919 bayes_pls_golite062009
kinase activity 0.691112783105676 bayes_pls_golite062009
histone methyltransferase activity 0.63002958837536 bayes_pls_golite062009
RNA helicase activity 0.6022754485555 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.499834566483656 bayes_pls_golite062009
GTPase activity 0.437665353870877 bayes_pls_golite062009
anion transmembrane-transporting ATPase activity 0.353150780751661 bayes_pls_golite062009
guanyl nucleotide binding 0.296406132096546 bayes_pls_golite062009
GTP binding 0.295705904888768 bayes_pls_golite062009
guanyl ribonucleotide binding 0.29028316917561 bayes_pls_golite062009
cation transmembrane transporter activity 0.282397764628576 bayes_pls_golite062009
ribonuclease activity 0.222424272323909 bayes_pls_golite062009
protein binding 0.170837278876362 bayes_pls_golite062009
inorganic anion transmembrane transporter activity 0.12168417344278 bayes_pls_golite062009
helicase activity 0.0775311459068899 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.0716139935283535 bayes_pls_golite062009
transcription factor activity 0.0434163635422169 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.0430764033739892 bayes_pls_golite062009
protein transporter activity 0.0397092337273124 bayes_pls_golite062009
protein transmembrane transporter activity 0.0378638259240902 bayes_pls_golite062009
protein kinase activity 0.0364322017534667 bayes_pls_golite062009
peptide transporter activity 0.0135927378126404 bayes_pls_golite062009
signal sequence binding 6.53725193420218E-4 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [577-685] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KSVTKFVAQI AIVELKSIIA AGFSCVMHVH TAIEEVHIVK LLHKLEKGTN RKSKKPPAFA  60
   61 KKGMKVIAVL ETEAPVCVET YQDYPQLGRF TLRDQGTTIA IGKIVKIAE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1862.218487
Match: 1jnyA_
Description: Elongation factor eEF-1alpha, domain 2; Elongation factor eEF-1alpha, C-terminal domain; Elongation factor eEF-1alpha, N-terminal (G) domain
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle