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View Structure Prediction Details

Protein: par-1-PL
Organism: Drosophila melanogaster
Length: 833 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for par-1-PL.

Description E-value Query
Range
Subject
Range
par-1-PA - The gene par-1 is referred to in FlyBase by the symbol Dmel\par-1 (CG8201, FBgn0260934). It is a pro...
530.0 [0..1] [831..1]

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Predicted Domain #1
Region A:
Residues: [1-138]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTAMRTTLQ SVPEALPADS VSNGTASNVA APAAPVSSAT NAVPPLAAVS STTATYATNS  60
   61 ISTSSHSVKD QQQQQQQQQH DSANANIVSL PPTTTPVANT NTMMPIVTSS NSATSNSTAA 120
  121 TPTPASGAAA TGGVGSVS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [139-512]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QGPATVSASA ANTNHSHQHS HQHHHHVANN MTTDGARLSS NNSAVVASSA INHHHHHTPG  60
   61 SGVAPTVNKN VLSTHSAHPS AIKQRTSSAK GSPNMQMRSS APMRWRATEE HIGKYKLIKT 120
  121 IGKGNFAKVK LAKHLPTGKE VAIKIIDKTQ LNPGSLQKLF REVRIMKMLD HPNIVKLFQV 180
  181 IETEKTLYLI MEYASGGEVF DYLVLHGRMK EKEARVKFRQ IVSAVQYCHQ KRIIHRDLKA 240
  241 ENLLLDSELN IKIADFGFSN EFTPGSKLDT FCGSPPYAAP ELFQGKKYDG PEVDVWSLGV 300
  301 ILYTLVSGSL PFDGSTLREL RERVLRGKYR IPFYMSTDCE NLLRKFLVLN PAKRASLETI 360
  361 MGDKWMNMGF EEDE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 49.0
Match: 1k9aA
Description: Carboxyl-terminal src kinase (csk)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
binding 3.12724619324809 bayes_pls_golite062009
tubulin binding 2.18641675163967 bayes_pls_golite062009
protein binding 2.14586566310919 bayes_pls_golite062009
cytoskeletal protein binding 2.12615078788254 bayes_pls_golite062009
telethonin binding 2.01406978272617 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
microtubule binding 1.88110801192607 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
protein kinase activity 1.4654611643382 bayes_pls_golite062009
JUN kinase kinase kinase activity 1.41172362253967 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.39494498759145 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.38496328649031 bayes_pls_golite062009
molecular adaptor activity 1.33740973673697 bayes_pls_golite062009
actin binding 1.33479685165255 bayes_pls_golite062009
kinase activity 1.31102709888086 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.27380124084989 bayes_pls_golite062009
SH3/SH2 adaptor activity 1.2323381312171 bayes_pls_golite062009
alpha-actinin binding 1.13281682085386 bayes_pls_golite062009
nucleic acid binding 1.07096365875131 bayes_pls_golite062009
molecular transducer activity 0.999269271132931 bayes_pls_golite062009
signal transducer activity 0.999269271132931 bayes_pls_golite062009
transcription regulator activity 0.97708452811666 bayes_pls_golite062009
cyclin-dependent protein kinase activity 0.959360414036299 bayes_pls_golite062009
protein binding, bridging 0.83823250804321 bayes_pls_golite062009
DNA binding 0.769534291245681 bayes_pls_golite062009
structural constituent of cytoskeleton 0.612883428421652 bayes_pls_golite062009
transferase activity 0.4880159130787 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
actin filament binding 0.2403700250846 bayes_pls_golite062009
transporter activity 0.187543377461637 bayes_pls_golite062009
transcription factor activity 0.142192219696991 bayes_pls_golite062009
kinase regulator activity 0.10704587503284 bayes_pls_golite062009
MAP kinase activity 0.08504542461349 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.0556163711947139 bayes_pls_golite062009
transmembrane transporter activity 0.0413380592707298 bayes_pls_golite062009
transmembrane receptor activity 0.00652065412910241 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [513-569]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LKPYIEPKAD LADPKRIEAL VAMGYNRSEI EASLSQVRYD DVFATYLLLG RKSTDPE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 98.0
Match: 2qnjA
Description: No description for 2qnjA was found.

Predicted Domain #4
Region A:
Residues: [570-833]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SDGSRSGSSL SLRNISGNDA GANAGSASVQ SPTHRGVHRS ISASSTKPSR RASSGVGPTN  60
   61 AAATVAAATG AVGAVNPSNN YNAAGSAADR ASVGSNFKRQ NTIDSATIKE NTARLAAQNQ 120
  121 RPASATQKML TTADTTLNSP AKPRTATKYD PTNGNRTVSG TSGIIPRRST TLYEKTSSTE 180
  181 KTNVIPAETN LFDRLRMASA VKSSRHFPRN VPSRSTFHSG QTRARNNTAL EYSGTSGASG 240
  241 DSSHPGRMSF FSKLSSRFSK RPNQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle