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Protein Overview: par-1-PA

General Information:
Name(s) found: par-1-PA / FBpp0085646 [FlyBase]
Description(s) found:
Found 23 descriptions.
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  • The gene par-1 is referred to in FlyBase by the symbol Dmel\par-1 (CG8201, FBgn0260934). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:15343679..15371978. It has the cytological map location 56D9-57D12. There is experimental evidence that it has the molecular function</span>: tau-protein kinase activity; protein kinase activity. There is experimental evidence for 14 unique biological process</span> terms, many of which group under: reproductive process in a multicellular organism; organelle organization; ovarian follicle cell development; regulation of developmental process; multicellular organism reproduction; regulation of cell morphogenesis; oocyte axis specification; regulation of cellular component organization; microtubule cytoskeleton organization; immune response; actin filament-based process; delamination. 59 alleles are reported. The phenotypes of these alleles are annotated with 13 unique terms, many of which group under: organ system; external compound sense organ; peripheral nervous system; female germline cyst; cuticle; abdominal ventral denticle belt; nervous system; compound cell cluster organ; blastoderm embryo; abdominal 5 ventral denticle belt; embryonic segment. It has 19 annotated transcripts and 19 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 938 amino acids

    Gene Ontology:
    Cellular Component: germline ring canal [IDA]
    cell cortex [IDA]
    fusome [IDA]
    basolateral plasma membrane [IDA]
    Biological Process: regulation of cell shape [IMP]
    germarium-derived oocyte fate determination [IMP][TAS]
    axis specification [IMP]
    border follicle cell delamination [IMP]
    actin filament organization [IMP]
    gamete generation [IMP]
    border follicle cell migration [IMP]
    oocyte differentiation [TAS]
    microtubule cytoskeleton organization [IMP]
    protein amino acid phosphorylation [ISS][NAS]
    oocyte anterior/posterior axis specification [TAS]
    anterior/posterior axis specification [TAS]
    maintenance of protein location [TAS]
    regulation of pole plasm oskar mRNA localization [IMP]
    pole plasm protein localization [IMP]
    oocyte nucleus localization involved in oocyte dorsal/ventral axis specification [IMP]
    ovarian follicle cell development [IMP]
    pole plasm oskar mRNA localization [TAS]
    regulation of Wnt receptor signaling pathway [TAS]
    antimicrobial humoral response [IMP]
    oocyte microtubule cytoskeleton organization [IMP][TAS]
    Molecular Function: tau-protein kinase activity [IDA]
    ATP binding [IEA]
    protein kinase activity [IDA]
    protein serine/threonine kinase activity [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTAMRTTLQ SVPEALPADS VSNGTASNVA APAAPVSSAT NAVPPLAAVS STTATYATNS  60
   61 ISTSSHSVKD QQQQQQQQQH DSANANIVSL PPTTTPVANT NTMMPIVTSS NSATSNSTAA 120
  121 TPTPASGAAA TGGVGSVSQG PATVSASAAN TNHSHQHSHQ HHHHVANNMT TDGARLSSNN 180
  181 SAVVASSAIN HHHHHTPGSG VAPTVNKNVL STHSAHPSAI KQRTSSAKGS PNMQMRSSAP 240
  241 MRWRATEEHI GKYKLIKTIG KGNFAKVKLA KHLPTGKEVA IKIIDKTQLN PGSLQKLFRE 300
  301 VRIMKMLDHP NIVKLFQVIE TEKTLYLIME YASGGEVFDY LVLHGRMKEK EARVKFRQIV 360
  361 SAVQYCHQKR IIHRDLKAEN LLLDSELNIK IADFGFSNEF TPGSKLDTFC GSPPYAAPEL 420
  421 FQGKKYDGPE VDVWSLGVIL YTLVSGSLPF DGSTLRELRE RVLRGKYRIP FYMSTDCENL 480
  481 LRKFLVLNPA KRASLETIMG DKWMNMGFEE DELKPYIEPK ADLADPKRIE ALVAMGYNRS 540
  541 EIEASLSQVR YDDVFATYLL LGRKSTDPES DGSRSGSSLS LRNISGNDAG ANAGSASVQS 600
  601 PTHRGVHRSI SASSTKPSRR ASSGVGPTNA AATVAAATGA VGAVNPSNNY NAAGSAADRA 660
  661 SVGSNFKRQN TIDSATIKEN TARLAAQNQR PASATQKMLT TADTTLNSPA KPRTATKYDP 720
  721 TNGNRTVSGT SGIIPRRSTT LYEKTSSTEK TNVIPAETNL FDRLRMASAV KSSRHFPRNV 780
  781 PSRSTFHSGQ TRARNNTALE YSGTSGASGD SSHPGRMSFF SKLSSRFSKR PTIADEAAKP 840
  841 RVLRFTWSMK TTSPLMPDQI MQKIREVLDQ NNCDYEQRER FVLWCVHGDP NTDSLVQWEI 900
  901 EVCKLPRLSL NGVRFKRISG TSIGFKNIAS RIAFDLKL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..519] PSI-BLAST 68.0 No description for 2h8hA was found.
    2 View Details [520..598] FFAS03 0.974 Solution Structure of RSGI RUH-012, a UBA Domain from Mouse cDNA
    3 View Details [599..844] deduced N/A No confident structure predictions are available.
    4 View Details [845..938] PSI-BLAST 44.045757 Solution structure of kinase associated domain 1 of mouse MAP/microtubule affinity-regulating kinase 3

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.04467222534257 bayes_pls_golite062009
  • kinase activity
    		•  4.85903980916957 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.63692708178478 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.26787750561728 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • tubulin binding
    		•  2.18641675163967 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.12615078788254 bayes_pls_golite062009
  • telethonin binding
    		•  2.01406978272617 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • microtubule binding
    		•  1.88110801192607 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • JUN kinase kinase kinase activity
    		•  1.41172362253967 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.3898059094397 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.38496328649031 bayes_pls_golite062009
  • molecular adaptor activity
    		•  1.33740973673697 bayes_pls_golite062009
  • actin binding
    		•  1.33479685165255 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.27291233344322 bayes_pls_golite062009
  • SH3/SH2 adaptor activity
    		•  1.2323381312171 bayes_pls_golite062009
  • protein binding
    		•  1.22565748038754 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • alpha-actinin binding
    		•  1.13281682085386 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.959360414036299 bayes_pls_golite062009
  • protein binding, bridging
    		•  0.83823250804321 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.612883428421652 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.444972929276369 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • signal transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • actin filament binding
    		•  0.2403700250846 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.222474717779546 bayes_pls_golite062009
  • DNA binding
    		•  0.198054762876122 bayes_pls_golite062009
  • transporter activity
    		•  0.187543377461637 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.0556163711947139 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.0413380592707298 bayes_pls_golite062009
  • transcription factor activity
    		•  0.026050048647416 bayes_pls_golite062009
  • MAP kinase kinase kinase kinase activity
    		•  0.01826424351081 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.00652065412910241 bayes_pls_golite062009
    2
    Term Confidence Notes
  • binding
    		•  2.36429435103114 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.20024206233026 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.02448431026096 bayes_pls_golite062009
  • protein binding
    		•  1.01573863836689 bayes_pls_golite062009
  • DNA binding
    		•  0.857155321682303 bayes_pls_golite062009
  • small conjugating protein binding
    		•  0.490118840379627 bayes_pls_golite062009
  • ubiquitin binding
    		•  0.319972124839967 bayes_pls_golite062009
  • catalytic activity
    		•  0.2736776367506 bayes_pls_golite062009
    3 No functions predicted.
    4
    Term Confidence Notes
  • protein kinase activity
    		•  4.05475891009228 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  3.7974128326421 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  3.59230737331367 bayes_pls_golite062009
  • kinase activity
    		•  3.41737435609334 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  3.2342722637405 bayes_pls_golite062009
  • binding
    		•  2.41732321506551 bayes_pls_golite062009
  • transferase activity
    		•  2.04713540681686 bayes_pls_golite062009
  • ATP binding
    		•  1.44435058039859 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.41005152726625 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.38971642420542 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.16863558166547 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.16859376715941 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.15633908642115 bayes_pls_golite062009
  • nucleotide binding
    		•  1.14964488472581 bayes_pls_golite062009
  • AMP-activated protein kinase activity
    		•  1.12923456567012 bayes_pls_golite062009
  • catalytic activity
    		•  0.836142537655721 bayes_pls_golite062009
  • protein binding
    		•  0.704339182896017 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.439688030503848 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle