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View Structure Prediction Details

Protein: ACS1_YEAST
Organism: Saccharomyces cerevisiae S288c
Length: 713 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ACS1_YEAST.

Description E-value Query
Range
Subject
Range
ACS1_YEAST - Acetyl-coenzyme A synthetase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ACS1 PE=1...
ACS1 - Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histo...
0.0 [1..713] [1..713]
ACSA2_PSEAE, ACS... - Acetyl-coenzyme A synthetase 2 OS=Pseudomonas aeruginosa GN=acsA2 PE=3 SV=1, (Q9HV66) Acetyl-coenzym...
ACSA2_PSEAE - Acetyl-coenzyme A synthetase 2 OS=Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / ...
0.0 [54..709] [2..640]
gi|17986522, gi|... - gi|17986522|ref|NP_539156.1| acetyl-coenzyme A synthetase [Brucella melitensis 16M], gi|17982126|gb|...
gi|25293392 - gi|25293392|pir||AI3281 acetate-CoA ligase (EC 6.2.1.1) [imported] - Brucella melitensis (strain 16M...
0.0 [46..709] [12..664]
ACSA_SALTI - Acetyl-coenzyme A synthetase OS=Salmonella typhi GN=acs PE=3 SV=1
gi|213427241 - gi|213427241|ref|ZP_03359991.1| acetyl-CoA synthetase [Salmonella enterica subsp. enterica serovar T...
gi|213163052 - gi|213163052|ref|ZP_03348762.1| acetyl-CoA synthetase [Salmonella enterica subsp. enterica serovar T...
gi|16762956 - gi|16762956|ref|NP_458573.1| acetyl-CoA synthetase [Salmonella enterica subsp. enterica serovar Typh...
ACSA_SALTI - Acetyl-coenzyme A synthetase OS=Salmonella typhi GN=acs PE=3 SV=1
gi|29144443, gi|... - gi|29144443|ref|NP_807785.1| acetyl-CoA synthetase [Salmonella enterica subsp. enterica serovar Typh...
gi|214002545 - gi|214002545|ref|ZP_03413280.1| acetyl-CoA synthetase [Salmonella enterica subsp. enterica serovar T...
gi|213852760 - gi|213852760|ref|ZP_03382292.1| acetyl-CoA synthetase [Salmonella enterica subsp. enterica serovar T...
0.0 [62..710] [10..644]
ACSA_SALTY - Acetyl-coenzyme A synthetase OS=Salmonella typhimurium GN=acs PE=1 SV=1
ACSA_SALTY - Acetyl-coenzyme A synthetase OS=Salmonella typhimurium GN=acs PE=1 SV=1
lcl|NC_016856.1_... - [gene=acs] [protein=acetyl-CoA synthetase] [protein_id=YP_005240576.1] [location=complement(4527256....
gi|197244220, gi... - gi|197265965|ref|ZP_03166039.1| acetate--CoA ligase [Salmonella enterica subsp. enterica serovar Sai...
ACSA_SALTY - Acetyl-coenzyme A synthetase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=acs ...
gi|205330151, gi... - gi|205330151|gb|EDZ16915.1| acetate--CoA ligase [Salmonella enterica subsp. enterica serovar 4,[5],1...
0.0 [62..710] [10..644]
gi|254164004, gi... - gi|254164004|ref|YP_003047112.1| acetyl-coenzyme A synthetase [Escherichia coli B str. REL606], gi|2...
gi|83587193, gi|... - gi|83587193|ref|ZP_00925822.1| COG0365: Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Escher...
gi|157159006, gi... - gi|75188792|ref|ZP_00702059.1| COG0365: Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Escher...
gi|194426861, gi... - gi|75211996|ref|ZP_00712051.1| COG0365: Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Escher...
gi|75238604, gi|... - gi|75238604|ref|ZP_00722593.1| COG0365: Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Escher...
gi|75258987, gi|... - gi|75258987|ref|ZP_00730355.1| COG0365: Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Escher...
EG11448 - acetyl-CoA synthetase / Acetyl CoA synthase, acetate-scavenging enzyme, improves carbon starvation s...
gi|85676821, gi|... - gi|89110790|ref|AP_004570.1| bifunctional acetyl-CoA synthetase and propionyl-CoA synthetase [Escher...
EG11448 - acetyl-CoA synthetase / Acetyl CoA synthase, acetate-scavenging enzyme, improves carbon starvation s...
ACSA_ECOLI - Acetyl-coenzyme A synthetase (EC 6.2.1.1) (Acetate--CoA ligase) (Acyl-activating enzyme) - Escherich...
gi|218697778, gi... - gi|218697778|ref|YP_002405445.1| acetyl-CoA synthetase [Escherichia coli 55989], gi|218354510|emb|CA...
gi|218556627, gi... - gi|218556627|ref|YP_002389541.1| acetyl-CoA synthetase [Escherichia coli IAI1], gi|218363396|emb|CAR...
gi|169756860, gi... - gi|170021932|ref|YP_001726886.1| acetyl-CoA synthetase [Escherichia coli ATCC 8739], gi|169756860|gb...
gi|238903178, gi... - gi|238903178|ref|YP_002928974.1| acetyl-CoA synthetase [Escherichia coli BW2952], gi|238859913|gb|AC...
gi|251787323, gi... - gi|251787323|ref|YP_003001627.1| hypothetical protein B21_03901 [Escherichia coli BL21], gi|24237959...
gi|124527708, gi... - gi|124527708|ref|ZP_01699143.1| acetate--CoA ligase [Escherichia coli B], gi|124501151|gb|EAY48617.1...
gi|209921555, gi... - gi|209921555|ref|YP_002295639.1| acetyl-CoA synthetase [Escherichia coli SE11], gi|209914814|dbj|BAG...
gi|254290754, gi... - gi|254290754|ref|YP_003056502.1| acetyl-coenzyme A synthetase [Escherichia coli BL21(DE3)], gi|25398...
gi|170083524, gi... - gi|170083524|ref|YP_001732844.1| acetyl-CoA synthetase [Escherichia coli str. K-12 substr. DH10B], g...
gi|226840180, gi... - gi|254037074|ref|ZP_04871151.1| acetyl-coenzyme A synthetase [Escherichia sp. 1_1_43], gi|226840180|...
0.0 [62..710] [10..644]
gi|167426184, gi... - gi|167426184|ref|ZP_02317937.1| acetate--CoA ligase [Yersinia pestis biovar Mediaevalis str. K197300...
gi|167468260 - gi|167468260|ref|ZP_02332964.1| acetate--CoA ligase [Yersinia pestis FV-1]
ACSA_YERPE - Acetyl-coenzyme A synthetase OS=Yersinia pestis GN=acs PE=3 SV=2
gi|165990673, gi... - gi|166010583|ref|ZP_02231481.1| acetate--CoA ligase [Yersinia pestis biovar Antiqua str. E1979001], ...
gi|166213894, gi... - gi|166213894|ref|ZP_02239929.1| acetate--CoA ligase [Yersinia pestis biovar Antiqua str. B42003004],...
gi|167048137, gi... - gi|167402487|ref|ZP_02307942.1| acetate--CoA ligase [Yersinia pestis biovar Antiqua str. UG05-0454],...
gi|229836504, gi... - gi|229836504|ref|ZP_04456670.1| acetyl-coenzyme A synthetase [Yersinia pestis Pestoides A], gi|22970...
gi|167418710, gi... - gi|167418710|ref|ZP_02310463.1| acetate--CoA ligase [Yersinia pestis biovar Orientalis str. MG05-102...
gi|161511453 - gi|161511453|ref|NP_991800.2| acetyl-CoA synthetase [Yersinia pestis biovar Microtus str. 91001]
gi|229842194, gi... - gi|229842194|ref|ZP_04462349.1| acetyl-coenzyme A synthetase [Yersinia pestis biovar Orientalis str....
gi|162354221, gi... - gi|162421406|ref|YP_001608244.1| acetyl-CoA synthetase [Yersinia pestis Angola], gi|162354221|gb|ABX...
gi|229696479, gi... - gi|229840113|ref|ZP_04460272.1| acetyl-coenzyme A synthetase [Yersinia pestis biovar Orientalis str....
ACSA_YERPN - Acetyl-coenzyme A synthetase OS=Yersinia pestis bv. Antiqua (strain Nepal516) GN=acs PE=3 SV=1
gi|165921419, gi... - gi|165926796|ref|ZP_02222628.1| acetate--CoA ligase [Yersinia pestis biovar Orientalis str. F1991016...
ACSA_YERPA - Acetyl-coenzyme A synthetase OS=Yersinia pestis bv. Antiqua (strain Antiqua) GN=acs PE=3 SV=1
gi|165936473, gi... - gi|165936473|ref|ZP_02225041.1| acetate--CoA ligase [Yersinia pestis biovar Orientalis str. IP275], ...
gi|218927458, gi... - gi|218927458|ref|YP_002345333.1| acetyl-CoA synthetase [Yersinia pestis CO92], gi|16120590|ref|NP_40...
gi|150260700, gi... - gi|150260700|ref|ZP_01917428.1| acetyl-coenzyme A synthetase [Yersinia pestis CA88-4125], gi|1492901...
ACSA_YERPP - Acetyl-coenzyme A synthetase OS=Yersinia pestis (strain Pestoides F) GN=acs PE=3 SV=1
0.0 [54..710] [1..644]
gi|15804661, gi|... - gi|15804661|ref|NP_290702.1| acetyl-CoA synthetase [Escherichia coli O157:H7 EDL933], gi|12519026|gb...
gi|217322623, gi... - gi|217326402|ref|ZP_03442486.1| acetate--CoA ligase [Escherichia coli O157:H7 str. TW14588], gi|2173...
gi|209751100, gi... - pir||G86100 acetyl-CoA synthetase [imported] - Escherichia coli (strain O157:H7, substrain EDL933),...
gi|209161294, gi... - gi|209399894|ref|YP_002273610.1| acetate--CoA ligase [Escherichia coli O157:H7 str. EC4115], gi|2091...
gi|208729342, gi... - gi|208809541|ref|ZP_03251878.1| acetate--CoA ligase [Escherichia coli O157:H7 str. EC4206], gi|20872...
gi|195935854 - gi|195935854|ref|ZP_03081236.1| acetyl-CoA synthetase [Escherichia coli O157:H7 str. EC4024]
gi|208818900, gi... - gi|208818900|ref|ZP_03259220.1| acetate--CoA ligase [Escherichia coli O157:H7 str. EC4042], gi|20873...
gi|208812711, gi... - gi|208812711|ref|ZP_03254040.1| acetate--CoA ligase [Escherichia coli O157:H7 str. EC4045], gi|20873...
gi|168780486, gi... - gi|189001801|gb|EDU70787.1| acetate--CoA ligase [Escherichia coli O157:H7 str. EC4076], gi|168780486...
gi|187769915, gi... - gi|187769915|gb|EDU33759.1| acetate--CoA ligase [Escherichia coli O157:H7 str. EC4196], gi|168774431...
gi|189379155, gi... - gi|189379155|gb|EDU97571.1| acetate--CoA ligase [Escherichia coli O157:H7 str. EC508], gi|168798264|...
gi|189375157, gi... - gi|189375157|gb|EDU93573.1| acetate--CoA ligase [Escherichia coli O157:H7 str. EC869], gi|168784689|...
gi|189357553, gi... - gi|189357553|gb|EDU75972.1| acetate--CoA ligase [Escherichia coli O157:H7 str. EC4401], gi|168755243...
gi|168748079, gi... - gi|188017377|gb|EDU55499.1| acetate--CoA ligase [Escherichia coli O157:H7 str. EC4113], gi|168748079...
ACSA_ECO57 - Acetyl-coenzyme A synthetase OS=Escherichia coli O157:H7 GN=acs PE=3 SV=1
gi|168766333, gi... - gi|189364237|gb|EDU82656.1| acetate--CoA ligase [Escherichia coli O157:H7 str. EC4486], gi|168766333...
gi|168760922, gi... - gi|189368558|gb|EDU86974.1| acetate--CoA ligase [Escherichia coli O157:H7 str. EC4501], gi|168760922...
gi|15834305, gi|... - gi|15834305|ref|NP_313078.1| acetyl-CoA synthetase [Escherichia coli O157:H7 str. Sakai], gi|1336452...
gi|254796089, gi... - gi|254796089|ref|YP_003080926.1| acetyl-CoA synthetase [Escherichia coli O157:H7 str. TW14359], gi|2...
0.0 [62..710] [10..644]
ACSA_RHILO - Acetyl-coenzyme A synthetase OS=Rhizobium loti GN=acsA PE=3 SV=1
ACSA_RHILO - Acetyl-coenzyme A synthetase OS=Rhizobium loti (strain MAFF303099) GN=acsA PE=3 SV=1
0.0 [56..709] [4..644]

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Predicted Domain #1
Region A:
Residues: [1-102]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSPSAVQSSK LEEQSSEIDK LKAKMSQSAA TAQQKKEHEY EHLTSVKIVP QRPISDRLQP  60
   61 AIATHYSPHL DGLQDYQRLH KESIEDPAKF FGSKATQFLN WS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.377 0.060 acetate-CoA ligase activity a.47.2 t-snare proteins
View Download 0.314 0.050 acetate-CoA ligase activity a.177.1 Sigma2 domain of RNA polymerase sigma factors
View Download 0.663 0.035 acetate-CoA ligase activity a.24.17 Group V grass pollen allergen
View Download 0.366 0.010 acetate-CoA ligase activity a.58.1 Chemotaxis receptor methyltransferase CheR, N-terminal domain
View Download 0.304 N/A N/A a.73.1 Retrovirus capsid protein, N-terminal core domain
View Download 0.274 N/A N/A a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.272 N/A N/A d.109.2 C-terminal, gelsolin-like domain of Sec23/24
View Download 0.268 N/A N/A a.70.1 N-terminal domain of the delta subunit of the F1F0-ATP synthase
View Download 0.265 N/A N/A c.51.3 B12-dependend dehydatases associated subunit
View Download 0.255 N/A N/A a.144.2 Ribosomal protein L20
View Download 0.236 N/A N/A a.61.1 Retroviral matrix proteins
View Download 0.235 N/A N/A a.60.6 DNA polymerase beta, N-terminal domain-like
View Download 0.231 N/A N/A a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.218 N/A N/A d.150.1 4'-phosphopantetheinyl transferase
View Download 0.214 N/A N/A a.35.1 lambda repressor-like DNA-binding domains

Predicted functions:

Term Confidence Notes
ligase activity, forming carbon-sulfur bonds 5.10123876514454 bayes_pls_golite062009
fatty acid ligase activity 4.83067429373059 bayes_pls_golite062009
long-chain fatty acid-CoA ligase activity 4.72692389032116 bayes_pls_golite062009
acetate-CoA ligase activity 4.48129067128523 bayes_pls_golite062009
acid-thiol ligase activity 4.28278725989432 bayes_pls_golite062009
CoA-ligase activity 4.12850865352867 bayes_pls_golite062009
ligase activity 2.49556073715112 bayes_pls_golite062009
catalytic activity 1.83545185797733 bayes_pls_golite062009
binding 1.5312519256537 bayes_pls_golite062009
transporter activity 1.29780964436121 bayes_pls_golite062009
transmembrane transporter activity 1.07143339827205 bayes_pls_golite062009
acetoacetate-CoA ligase activity 1.03788694975627 bayes_pls_golite062009
substrate-specific transporter activity 1.03753946113449 bayes_pls_golite062009
protein binding 0.985225190358794 bayes_pls_golite062009
transcription regulator activity 0.950362540931728 bayes_pls_golite062009
AMP binding 0.778227294974491 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.54797726647835 bayes_pls_golite062009
adenyl ribonucleotide binding 0.519946577969422 bayes_pls_golite062009
adenyl nucleotide binding 0.500908589473269 bayes_pls_golite062009
transferase activity, transferring acyl groups 0.464663038956639 bayes_pls_golite062009
luciferin monooxygenase activity 0.460892968031761 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.398310577427897 bayes_pls_golite062009
active transmembrane transporter activity 0.251681382273558 bayes_pls_golite062009
primary active transmembrane transporter activity 0.225448500718996 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 0.216579620878492 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0.177812048124158 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 0.174283007890308 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 0.173963339749644 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0401881910649647 bayes_pls_golite062009
pyrophosphatase activity 0.0047964784091391 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [103-117]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPFDKVFIPD PKTGR

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [387-574]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EGTPAYPNYS RYWDIIDEHK VTQFYVAPTA LRLLKRAGDS YIENHSLKSL RCLGSVGEPI  60
   61 AAEVWEWYSE KIGKNEIPIV DTYWQTESGS HLVTPLAGGV TPMKPGSASF PFFGIDAVVL 120
  121 DPNTGEELNT SHAEGVLAVK AAWPSFARTI WKNHDRYLDT YLNPYPGYYF TGDGAAKDKD 180
  181 GYIWILGR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 277.218487
Match: 1amuA_
Description: Phenylalanine activating domain of gramicidin synthetase 1
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [118-168]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSFQNNAWFL NGQLNACYNC VDRHALKTPN KKAIIFEGDE PGQGYSITYK E

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [322-386]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSTGAPKGVQ HSTAGYLLGA LLTMRYTFDT HQEDVFFTAG DIGWITGHTY VVYGPLLYGC  60
   61 ATLVF

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [575-713]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VDDVVNVSGH RLSTAEIEAA IIEDPIVAEC AVVGFNDDLT GQAVAAFVVL KNKSSWSTAT  60
   61 DDELQDIKKH LVFTVRKDIG PFAAPKLIIL VDDLPKTRSG KIMRRILRKI LAGESDQLGD 120
  121 VSTLSNPGIV RHLIDSVKL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 277.218487
Match: 1amuA_
Description: Phenylalanine activating domain of gramicidin synthetase 1
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [169-321]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LLEEVCQVAQ VLTYSMGVRK GDTVAVYMPM VPEAIITLLA ISRIGAIHSV VFAGFSSNSL  60
   61 RDRINDGDSK VVITTDESNR GGKVIETKRI VDDALRETPG VRHVLVYRKT NNPSVAFHAP 120
  121 RDLDWATEKK KYKTYYPCTP VDSEDPLFLL YTS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 277.218487
Match: 1amuA_
Description: Phenylalanine activating domain of gramicidin synthetase 1
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle