Bait Protein: | CWC2 |
Organism: | Saccharomyces cerevisiae |
Publication: | Hazbun TR, et al. (2003) Assigning function to yeast proteins by integration of technologies. Mol Cell 12(6):1353-65 |
Comments: | No comments. |
Raw Data: |
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UNFILTERED Run Results:
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Hit Protein | Protein Desc | Sequence Count | Spectrum Count | Sequence Coverage | NSAF | Mol. Wt. | |
[ |
SMX2 | Core Sm protein Sm G; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and ... | 2 | 2 | 11.7% | 0.0124 | 8482 |
[ |
SMD3 | Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and... | 5 | 10 | 62.4% | 0.0473 | 11224 |
[ |
MSL1 | U2B component of U2 snRNP, involved in splicing, binds the U2 snRNA stem-loop IV in vitro but requir... | 2 | 3 | 27.0% | 0.0129 | 12830 |
[ |
SMD2 | Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and... | 3 | 10 | 31.8% | 0.0435 | 12853 |
[ |
NTC20 | Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms... | 3 | 3 | 19.3% | 0.0102 | 15970 |
[ |
SMD1 | Core Sm protein Sm D1; part of heteroheptameric complex (with Smb1p, Smd2p, Smd3p, Sme1p, Smx3p, and... | 7 | 14 | 64.4% | 0.0458 | 16275 |
[ |
IST3 | Component of the U2 snRNP, required for the first catalytic step of splicing and for spliceosomal as... | 2 | 2 | 25.7% | 0.00646 | 17098 |
[ |
BUD31 | Component of the SF3b subcomplex of the U2 snRNP; diploid mutants display a random budding pattern i... | 2 | 4 | 13.4% | 0.0122 | 18447 |
[ |
ATP7 | Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily c... | 2 | 2 | 21.8% | 0.0055 | 19810 |
[ |
CWC15 | Non-essential protein involved in pre-mRNA splicing, component of a complex containing Cef1p; has si... | 3 | 5 | 19.4% | 0.0137 | 19935 |
[ |
SNT309 | Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms... | 12 | 38 | 66.3% | 0.104 | 20709 |
[ |
SMB1 | Core Sm protein Sm B; part of heteroheptameric complex (with Smd1p, Smd2p, Smd3p, Sme1p, Smx3p, and ... | 4 | 13 | 23.0% | 0.0317 | 22379 |
[ |
HSH49 | U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49; proposed... | 2 | 2 | 11.3% | 0.00449 | 24503 |
[ |
SYF2 | Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms... | 7 | 13 | 37.2% | 0.0289 | 24803 |
[ |
CLC1 | Clathrin light chain, subunit of the major coat protein involved in intracellular protein transport ... | 2 | 6 | 12.4% | 0.0123 | 26532 |
[ |
LEA1 | Component of U2 snRNP; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; p... | 4 | 4 | 24.8% | 0.00803 | 27193 |
[ |
BUD13 | Subunit of the RES complex, which is required for nuclear pre-mRNA retention and splicing; involved ... | 2 | 2 | 9.0% | 0.00359 | 30472 |
[ |
MRPL13 | Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation | 3 | 3 | 18.5% | 0.00522 | 31526 |
[ |
YJU2 | Essential protein required for pre-mRNA splicing; associates transiently with the spliceosomal NTC (... | 2 | 2 | 12.2% | 0.00344 | 32312 |
[ |
NTR2 | Essential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box ... | 2 | 4 | 14.0% | 0.00594 | 36647 |
[ |
CWC2 | Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms... | 21 | 40 | 50.7% | 0.0564 | 38431 |
[ |
ECM2 | Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association wit... | 13 | 22 | 35.7% | 0.0289 | 40925 |
[ |
CWC23 | Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to... | 3 | 3 | 17.0% | 0.00413 | 40951 |
[ |
YOR390W | Putative protein of unknown function | 1 | 10 | 5.1% | 0.0127 | 41985 |
[ |
PRP45 | Protein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing ... | 17 | 38 | 46.4% | 0.0479 | 42483 |
[ |
CUS1 | Protein required for assembly of U2 snRNP into the spliceosome, forms a complex with Hsh49p and Hsh1... | 2 | 3 | 6.0% | 0.00329 | 50253 |
[ |
PRP46 | Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms... | 18 | 40 | 36.6% | 0.0424 | 50700 |
[ |
CDC40 | Pre-mRNA splicing factor, important for catalytic step II of pre-mRNA splicing and plays a role in c... | 13 | 25 | 37.1% | 0.0263 | 52048 |
[ |
PRP19 | Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiqu... | 32 | 155 | 51.5% | 0.147 | 56570 |
[ |
DRN1 | Putative protein of unconfirmed function; green fluorescent protein (GFP)-fusion protein localizes t... | 2 | 2 | 3.9% | 0.00189 | 58206 |
[ |
CWC22 | Essential protein, component of a complex containing Cef1p, has similarity to S. pombe Cwf22p; putat... | 6 | 12 | 12.7% | 0.00994 | 67294 |
[ |
CEF1 | Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb ... | 23 | 55 | 38.6% | 0.0446 | 67731 |
[ |
SLY1 | Hydrophilic protein involved in vesicle trafficking between the ER and Golgi; SM (Sec1/Munc-18) fami... | 2 | 2 | 3.9% | 0.00144 | 74679 |
[ |
CLF1 | Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms... | 18 | 48 | 31.9% | 0.0334 | 82445 |
[ |
SPP382 | Essential protein that forms a dimer with Ntr2p; also forms a trimer, with Ntr2p and Prp43p, that is... | 8 | 11 | 13.4% | 0.00743 | 83049 |
[ |
PRP43 | RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript... | 9 | 12 | 15.5% | 0.00748 | 87562 |
[ |
SYF1 | Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms... | 22 | 45 | 30.3% | 0.025 | 100229 |
[ |
HSH155 | U2-snRNP associated splicing factor that forms extensive associations with the branch site-3' splice... | 5 | 7 | 7.4% | 0.00345 | 110028 |
[ |
SNU114 | GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; ... | 35 | 83 | 42.7% | 0.0394 | 114041 |
[ |
MTC5 | Protein of unknown function; mtc5 is synthetically sick with cdc13-1 | 2 | 2 | 2.4% | 8.33E-4 | 130946 |
[ |
RSE1 | Protein involved in pre-mRNA splicing; component of the pre-spliceosome; associates with U2 snRNA; i... | 10 | 12 | 10.0% | 0.00422 | 153784 |
[ |
CDC25 | Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates ... | 2 | 2 | 2.1% | 6.02E-4 | 179091 |
[ |
BRR2 | RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in nativ... | 23 | 35 | 14.8% | 0.00774 | 246183 |
[ |
PRP8 | Component of the U4/U6-U5 snRNP complex, involved in the second catalytic step of splicing; mutation... | 69 | 130 | 31.7% | 0.0258 | 279502 |