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View Protein Complex Details

Complex Overview

From Publication: Qiu J, Noble WS (2008) Predicting Co-Complexed Protein Pairs from Heterogeneous Data. PLoS Comput Biol 4(4): e1000054. doi:10.1371/journal.pcbi.1000054
Notes: Classifier used Gene Ontology annotations. [FDR: 0.02] [SVM Score: 1.38406700899]
Complex Size: 2 proteins

Complex Member Proteins

Protein

 GO Cellular Component GO Biological Process GO Molecular Function
PPH21
  • protein phosphatase type 2A complex
    		•
  • mitotic cell cycle spindle assembly checkpoint
  • G1/S transition of mitotic cell cycle
  • protein amino acid dephosphorylation
  • actin filament organization
  • budding cell bud growth
  • translation
    		•
  • protein serine/threonine phosphatase activity
  • phosphoprotein phosphatase activity
  • metal ion binding
  • hydrolase activity
    		•
    PPH22
  • condensed nuclear chromosome, centromeric region
  • protein phosphatase type 2A complex
    		•
  • mitotic cell cycle spindle assembly checkpoint
  • G1/S transition of mitotic cell cycle
  • protein amino acid dephosphorylation
  • actin filament organization
  • budding cell bud growth
  • translation
    		•
  • protein serine/threonine phosphatase activity
  • phosphoprotein phosphatase activity
  • metal ion binding
  • hydrolase activity
    		•

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    protein phosphatase type 2A complex 7.579E-7 2 6 2 6292
    protein serine/threonine phosphatase complex 6.8716E-6 2 17 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    mitotic cell cycle spindle assembly checkpoint 1.0611E-5 2 21 2 6292
    negative regulation of mitotic metaphase/anaphase transition 1.0611E-5 2 21 2 6292
    spindle assembly checkpoint 1.0611E-5 2 21 2 6292
    negative regulation of nuclear division 1.0611E-5 2 21 2 6292
    negative regulation of mitosis 1.0611E-5 2 21 2 6292
    negative regulation of cell cycle 1.1672E-5 2 22 2 6292
    regulation of mitotic metaphase/anaphase transition 1.5158E-5 2 25 2 6292
    mitotic cell cycle spindle checkpoint 1.5158E-5 2 25 2 6292
    spindle checkpoint 1.5158E-5 2 25 2 6292
    mitotic cell cycle checkpoint 1.9099E-5 2 28 2 6292
    protein amino acid dephosphorylation 1.9099E-5 2 28 2 6292
    negative regulation of cellular component organization 2.0514E-5 2 29 2 6292
    regulation of nuclear division 2.0514E-5 2 29 2 6292
    negative regulation of organelle organization 2.0514E-5 2 29 2 6292
    regulation of mitosis 2.0514E-5 2 29 2 6292
    negative regulation of cell cycle process 2.5061E-5 2 32 2 6292
    budding cell bud growth 2.8346E-5 2 34 2 6292
    mitotic metaphase/anaphase transition 3.3651E-5 2 37 2 6292
    dephosphorylation 3.9411E-5 2 40 2 6292
    G1/S transition of mitotic cell cycle 6.1895E-5 2 50 2 6292
    regulation of organelle organization 6.6999E-5 2 52 2 6292
    cell cycle checkpoint 8.3521E-5 2 58 2 6292
    actin filament organization 1.151E-4 2 68 2 6292
    regulation of mitotic cell cycle 1.2556E-4 2 71 2 6292
    regulation of cellular component organization 1.4021E-4 2 75 2 6292
    regulation of cell cycle process 1.6371E-4 2 81 2 6292
    asexual reproduction 2.0236E-4 2 90 2 6292
    cell budding 2.0236E-4 2 90 2 6292
    interphase of mitotic cell cycle 2.3525E-4 2 97 2 6292
    interphase 2.3525E-4 2 97 2 6292
    mitosis 2.7062E-4 2 104 2 6292
    nuclear division 2.8118E-4 2 106 2 6292
    organelle fission 3.1973E-4 2 113 2 6292
    actin cytoskeleton organization 3.1973E-4 2 113 2 6292
    actin filament-based process 3.4287E-4 2 117 2 6292
    M phase of mitotic cell cycle 4.1068E-4 2 128 2 6292
    regulation of cell cycle 4.3024E-4 2 131 2 6292
    growth 5.275E-4 2 145 2 6292
    cell division 5.275E-4 2 145 2 6292
    signal transduction 1.1516E-3 2 214 2 6292
    signal transmission 1.1841E-3 2 217 2 6292
    signaling process 1.1841E-3 2 217 2 6292
    reproduction of a single-celled organism 1.1841E-3 2 217 2 6292
    phosphorus metabolic process 1.3191E-3 2 229 2 6292
    phosphate metabolic process 1.3191E-3 2 229 2 6292
    cytoskeleton organization 1.3422E-3 2 231 2 6292
    negative regulation of cellular process 1.5726E-3 2 250 2 6292
    signaling 1.598E-3 2 252 2 6292
    negative regulation of biological process 1.6107E-3 2 253 2 6292
    mitotic cell cycle 1.6363E-3 2 255 2 6292
    M phase 2.1762E-3 2 294 2 6292
    reproduction 2.7096E-3 2 328 2 6292
    post-translational protein modification 3.2108E-3 2 357 2 6292
    cell cycle phase 3.5621E-3 2 376 2 6292
    translation 3.5621E-3 2 376 2 6292
    cell cycle process 6.0534E-3 2 490 2 6292
    protein modification process 6.278E-3 2 499 2 6292
    cell cycle 6.95E-3 2 525 2 6292
    macromolecule modification 8.1649E-3 2 569 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    protein serine/threonine phosphatase activity 1.6421E-5 2 26 2 6292
    phosphoprotein phosphatase activity 4.5626E-5 2 43 2 6292
    metal ion binding 7.5032E-5 2 55 2 6292
    ion binding 7.7811E-5 2 56 2 6292
    cation binding 7.7811E-5 2 56 2 6292
    phosphatase activity 1.8902E-4 2 87 2 6292
    phosphoric ester hydrolase activity 2.6026E-4 2 102 2 6292
    hydrolase activity, acting on ester bonds 2.929E-3 2 341 2 6292
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