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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Seh1. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 6 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ADE13
  • cellular_component
  • purine nucleotide biosynthetic process
  • 'de novo' IMP biosynthetic process
  • N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity
  • NUP145
  • nuclear pore
  • tRNA splicing, via endonucleolytic cleavage and ligation
  • protein export from nucleus
  • ribosomal protein import into nucleus
  • mRNA export from nucleus
  • rRNA export from nucleus
  • nuclear pore organization
  • snRNP protein import into nucleus
  • mRNA-binding (hnRNP) protein import into nucleus
  • snRNA export from nucleus
  • protein import into nucleus
  • chromosome localization
  • tRNA export from nucleus
  • NLS-bearing substrate import into nucleus
  • RNA binding
  • structural molecule activity
  • NUP84
  • nuclear pore
  • DNA metabolic process
  • protein export from nucleus
  • response to DNA damage stimulus
  • ribosomal protein import into nucleus
  • mRNA export from nucleus
  • rRNA export from nucleus
  • nuclear envelope organization
  • nuclear pore organization
  • snRNP protein import into nucleus
  • mRNA-binding (hnRNP) protein import into nucleus
  • snRNA export from nucleus
  • chromosome localization
  • tRNA export from nucleus
  • NLS-bearing substrate import into nucleus
  • structural molecule activity
  • NUP85
  • nuclear pore
  • mRNA export from nucleus
  • rRNA export from nucleus
  • nuclear envelope organization
  • nuclear pore organization
  • snRNP protein import into nucleus
  • mRNA-binding (hnRNP) protein import into nucleus
  • snRNA export from nucleus
  • tRNA export from nucleus
  • NLS-bearing substrate import into nucleus
  • protein export from nucleus
  • ribosomal protein import into nucleus
  • structural molecule activity
  • SEC13
  • cytoplasm
  • extrinsic to membrane
  • COPII vesicle coat
  • nuclear pore
  • ER to Golgi vesicle-mediated transport
  • membrane budding
  • nuclear pore organization
  • ER-associated protein catabolic process
  • structural molecule activity
  • SEH1
  • nuclear pore
  • mRNA export from nucleus
  • rRNA export from nucleus
  • nuclear pore organization
  • snRNP protein import into nucleus
  • mRNA-binding (hnRNP) protein import into nucleus
  • snRNA export from nucleus
  • tRNA export from nucleus
  • NLS-bearing substrate import into nucleus
  • protein export from nucleus
  • ribosomal protein import into nucleus
  • structural molecule activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    pore complex 1.8887E-10 6 52 5 6292
    nuclear pore 1.8887E-10 6 52 5 6292
    nuclear envelope 1.7614E-7 6 199 5 6292
    integral to membrane 6.1071E-7 6 255 5 6292
    intrinsic to membrane 6.9933E-7 6 262 5 6292
    endomembrane system 5.6251E-6 6 398 5 6292
    envelope 1.8321E-5 6 505 5 6292
    organelle envelope 1.8321E-5 6 505 5 6292
    membrane part 6.967E-5 6 662 5 6292
    nuclear part 8.4241E-4 6 1103 5 6292
    protein complex 9.756E-4 6 1137 5 6292
    membrane 1.2554E-3 6 1198 5 6292
    macromolecular complex 5.5477E-3 6 1635 5 6292
    COPII vesicle coat 7.6075E-3 6 8 1 6292
    ER to Golgi transport vesicle membrane 7.6075E-3 6 8 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nuclear pore organization 7.165E-12 6 28 5 6292
    nucleus organization 2.7744E-10 6 56 5 6292
    ribosomal protein import into nucleus 2.026E-9 6 23 4 6292
    snRNP protein import into nucleus 2.026E-9 6 23 4 6292
    NLS-bearing substrate import into nucleus 2.026E-9 6 23 4 6292
    snRNA transport 2.026E-9 6 23 4 6292
    snRNA export from nucleus 2.026E-9 6 23 4 6292
    mRNA-binding (hnRNP) protein import into nucleus 2.8929E-9 6 25 4 6292
    rRNA transport 4.0114E-9 6 27 4 6292
    rRNA export from nucleus 4.0114E-9 6 27 4 6292
    tRNA transport 4.6787E-9 6 28 4 6292
    tRNA export from nucleus 4.6787E-9 6 28 4 6292
    protein export from nucleus 8.2088E-9 6 32 4 6292
    protein localization in nucleus 4.4237E-8 6 48 4 6292
    protein import into nucleus 4.4237E-8 6 48 4 6292
    nuclear import 4.4237E-8 6 48 4 6292
    mRNA transport 1.842E-7 6 68 4 6292
    mRNA export from nucleus 1.842E-7 6 68 4 6292
    RNA export from nucleus 3.5663E-7 6 80 4 6292
    RNA transport 3.7506E-7 6 81 4 6292
    nucleic acid transport 3.7506E-7 6 81 4 6292
    establishment of RNA localization 3.7506E-7 6 81 4 6292
    RNA localization 6.2811E-7 6 92 4 6292
    cellular macromolecular complex subunit organization 6.6017E-7 6 259 5 6292
    nucleobase, nucleoside, nucleotide and nucleic acid transport 7.4599E-7 6 96 4 6292
    nuclear export 9.9106E-7 6 103 4 6292
    protein import 1.1997E-6 6 108 4 6292
    nuclear transport 2.5285E-6 6 130 4 6292
    nucleocytoplasmic transport 2.5285E-6 6 130 4 6292
    macromolecular complex subunit organization 3.2755E-6 6 357 5 6292
    protein localization in organelle 4.3682E-6 6 149 4 6292
    chromosome localization 4.5436E-6 6 4 2 6292
    nuclear envelope organization 1.5882E-5 6 7 2 6292
    protein targeting 2.6828E-5 6 235 4 6292
    intracellular transport 2.8701E-5 6 553 5 6292
    intracellular protein transport 3.7074E-5 6 255 4 6292
    establishment of localization in cell 4.2574E-5 6 599 5 6292
    protein transport 4.58E-5 6 269 4 6292
    establishment of protein localization 4.716E-5 6 271 4 6292
    cellular protein localization 4.9256E-5 6 274 4 6292
    cellular macromolecule localization 5.6745E-5 6 284 4 6292
    cellular localization 6.0368E-5 6 643 5 6292
    protein localization 7.3253E-5 6 303 4 6292
    ribosome biogenesis 1.2345E-4 6 346 4 6292
    ribonucleoprotein complex biogenesis 1.675E-4 6 374 4 6292
    macromolecule localization 2.1156E-4 6 397 4 6292
    transport 5.1616E-4 6 997 5 6292
    establishment of localization 5.4442E-4 6 1008 5 6292
    cellular membrane organization 5.7233E-4 6 198 3 6292
    membrane organization 5.7233E-4 6 198 3 6292
    localization 6.9487E-4 6 1060 5 6292
    organelle organization 9.3483E-4 6 1127 5 6292
    cellular component biogenesis 1.8339E-3 6 694 4 6292
    organelle localization 2.6119E-3 6 85 2 6292
    cellular component organization 4.7462E-3 6 1582 5 6292
    membrane budding 4.7604E-3 6 5 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    structural molecule activity 2.5314E-6 6 339 5 6292
    N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity 9.5359E-4 6 1 1 6292
    amidine-lyase activity 1.9064E-3 6 2 1 6292
    carbon-nitrogen lyase activity 7.6075E-3 6 8 1 6292

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