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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Sif2. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 10 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
AVT2
  • endoplasmic reticulum
  • transport
  • transporter activity
  • HOS4
  • histone deacetylase complex
  • histone deacetylation
  • negative regulation of meiosis
  • NAD-dependent histone deacetylase activity
  • NAD-independent histone deacetylase activity
  • SIF2
  • nucleus
  • histone deacetylase complex
  • negative regulation of transcription from RNA polymerase II promoter
  • histone deacetylation
  • chromatin silencing at telomere
  • negative regulation of meiosis
  • transcription corepressor activity
  • NAD-dependent histone deacetylase activity
  • NAD-independent histone deacetylase activity
  • SNT1
  • histone deacetylase complex
  • histone deacetylation
  • negative regulation of meiosis
  • NAD-dependent histone deacetylase activity
  • NAD-independent histone deacetylase activity
  • TFP1
  • vacuolar proton-transporting V-type ATPase, V1 domain
  • fungal-type vacuole membrane
  • protein metabolic process
  • vacuolar acidification
  • intron homing
  • proton-transporting ATPase activity, rotational mechanism
  • endodeoxyribonuclease activity
  • TRM3
  • cytoplasm
  • tRNA methylation
  • RNA methyltransferase activity
  • tRNA (guanosine-2'-O-)-methyltransferase activity
  • RNA binding
  • methyltransferase activity
  • transferase activity
  • tRNA (guanine) methyltransferase activity
  • UTP21
  • nucleus
  • nuclear outer membrane
  • nucleolus
  • small nucleolar ribonucleoprotein complex
  • ribosome biogenesis
  • snoRNA binding
  • YMR155W
  • cellular_component
  • biological_process
  • molecular_function
  • YRF1-3, YRF1-7
  • nucleus
  • mitochondrion
  • regulation of cellular catabolic process
  • telomere maintenance via recombination
  • nucleotide binding
  • nucleic acid binding
  • ATP binding
  • DNA helicase activity
  • ATP-dependent helicase activity
  • helicase activity
  • hydrolase activity
  • ZDS2
  • nucleus
  • chromatin silencing at rDNA
  • cell aging
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    histone deacetylase complex 5.0366E-6 10 23 3 6292
    chromatin remodeling complex 4.1852E-4 10 99 3 6292
    nuclear lumen 3.9246E-3 10 453 4 6292
    nucleoplasm part 5.7104E-3 10 245 3 6292
    nucleoplasm 7.0364E-3 10 264 3 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    negative regulation of meiosis 1.6127E-7 10 8 3 6292
    regulation of meiosis 4.3833E-6 10 22 3 6292
    regulation of meiotic cell cycle 4.3833E-6 10 22 3 6292
    histone deacetylation 8.2906E-6 10 27 3 6292
    protein amino acid deacetylation 1.034E-5 10 29 3 6292
    negative regulation of cell cycle process 1.4E-5 10 32 3 6292
    regulation of cell cycle process 2.3113E-4 10 81 3 6292
    covalent chromatin modification 2.9553E-4 10 88 3 6292
    histone modification 2.9553E-4 10 88 3 6292
    negative regulation of cellular process 4.2283E-4 10 250 4 6292
    negative regulation of biological process 4.4258E-4 10 253 4 6292
    regulation of cell cycle 9.5103E-4 10 131 3 6292
    meiosis 1.698E-3 10 160 3 6292
    M phase of meiotic cell cycle 1.698E-3 10 160 3 6292
    meiotic cell cycle 1.8232E-3 10 164 3 6292
    chromatin modification 1.9542E-3 10 168 3 6292
    chromatin organization 3.3575E-3 10 203 3 6292
    regulation of cellular process 4.6602E-3 10 796 5 6292
    biological regulation 5.2241E-3 10 1213 6 6292
    regulation of biological process 5.4298E-3 10 824 5 6292
    chromosome organization 8.1671E-3 10 555 4 6292
    macromolecule modification 8.9239E-3 10 569 4 6292
    M phase 9.4842E-3 10 294 3 6292
    intron homing 9.5019E-3 10 6 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    NAD-independent histone deacetylase activity 1.0088E-7 10 7 3 6292
    NAD-dependent protein deacetylase activity 2.417E-7 10 9 3 6292
    NAD-dependent histone deacetylase activity 2.417E-7 10 9 3 6292
    protein deacetylase activity 1.4E-5 10 32 3 6292
    histone deacetylase activity 1.4E-5 10 32 3 6292
    deacetylase activity 1.8427E-5 10 35 3 6292
    hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 4.817E-5 10 48 3 6292
    hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 2.2276E-4 10 80 3 6292
    tRNA (guanosine-2'-O-)-methyltransferase activity 1.5893E-3 10 1 1 6292
    hydrolase activity 8.4227E-3 10 911 5 6292

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    Created and Maintained by: Michael Riffle